insulin secretagogue

WordNet

hormone secreted by the isles of Langerhans in the pancreas; regulates storage of glycogen in the liver and accelerates oxidation of sugar in cells

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1. 糖尿病の治療におけるスルホニル尿素およびメグリチニド sulfonylureas and meglitinides in the treatment of diabetes mellitus
2. インスリン分泌および膵β細胞の機能 insulin secretion and pancreatic beta cell function
3. 2型糖尿病におけるインスリン療法 insulin therapy in type 2 diabetes mellitus
4. 糖尿病におけるインスリン療法の一般原則 general principles of insulin therapy in diabetes mellitus
5. 糖尿病における吸入インスリン療法 inhaled insulin therapy in diabetes mellitus

Bioenergetic Analysis of Single Pancreatic β-Cells Indicates an Impaired Metabolic Signature in Type 2 Diabetic Subjects.

Gerencser AA1.
Endocrinology.Endocrinology.2015 Oct;156(10):3496-503. doi: 10.1210/en.2015-1552. Epub 2015 Jul 23.
Impaired activation of mitochondrial energy metabolism by glucose has been demonstrated in type 2 diabetic β-cells. The cause of this dysfunction is unknown. The aim of this study was to identify segments of energy metabolism with normal or with altered function in human type 2 diabetes mellitus. T
PMID 26204464

Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon.

Cheshmehkani A1, Senatorov IS1, Kandi P1, Singh M1, Britt A1, Hayslett R1, Moniri NH2.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].Inflamm Res.2015 Oct;64(10):809-15. doi: 10.1007/s00011-015-0864-3. Epub 2015 Aug 15.
BACKGROUND AND OBJECTIVE: Omega-3 fatty acids, such as α-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are polyunsaturated fatty acids (PUFA) that have long been associated with anti-inflammatory activity and general benefit toward human health. Over the last de
PMID 26275932

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.

Gooding JR1, Jensen MV1, Dai X2, Wenner BR1, Lu D1, Arumugam R1, Ferdaoussi M2, MacDonald PE3, Newgard CB4.
Cell reports.Cell Rep.2015 Sep 22. pii: S2211-1247(15)00985-7. doi: 10.1016/j.celrep.2015.08.072. [Epub ahead of print]
Pancreatic islet failure, involving loss of glucose-stimulated insulin secretion (GSIS) from islet β cells, heralds the onset of type 2 diabetes (T2D). To search for mediators of GSIS, we performed metabolomics profiling of the insulinoma cell line 832/13 and uncovered significant glucose-induced c
PMID 26411681