イノシンヌクレオチド
WordNet
- a nucleoside that is formed by the deamination of adenosine; used in kidney transplantation to provide a temporary source of sugar
- a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA) (同)base
UpToDate Contents
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English Journal
- Strategy of Metabolic Phenotype Modulation in Portunus trituberculatus Exposed to Low Salinity.
- Ye Y, An Y, Li R, Mu C, Wang C.AbstractExtreme low salinity influences normal crab growth, morphogenesis, and production. Some individuals of swimming crab Portunus trituberculatus have, however, an inherent ability to adapt to such a salinity fluctuation. Here, we investigated the dynamic metabolite alterations of two P. trituberculatus strains, namely a wild one and a screened (low salinity tolerant) one in response to low salinity challenge by combined use of NMR spectroscopy and high-throughput data analysis. Firstly, we found that the dominated metabolites in crab muscle comprise amino acids, sugars, carboxylic acids, betaine, trimethylamine-N-oxide, 2-pyridinemethanol, trigonelline, and nucleotides. Our results further showed that the strategy of metabolic modulation of P. trituberculatus after low salinity stimulus includes osmotic rebalancing, enhanced gluconeogenesis from amino acids and energy accumulation. These metabolic adaptions were manifested in the accumulation of trimethylamine-N-oxide, ATP, 2-pyridinemethanol, and trigonelline, and in the depletion of amino acid pool as well as in the fluctuation of inosine levels. This lends to the support of the fact that the low salinity training accelerates the responses of crabs to low salinity stress. These findings provide a comprehensive insight into the mechanisms of metabolic modulation in P. trituberculatus in response to low salinity. Our work highlights the approach of NMR-based metabonomics in conjunction with multivariate data analysis and univariate data analysis in understanding the strategy of metabolic phenotype modulation against stressors.
- Journal of agricultural and food chemistry.J Agric Food Chem.2014 Mar 24. [Epub ahead of print]
- Extreme low salinity influences normal crab growth, morphogenesis, and production. Some individuals of swimming crab Portunus trituberculatus have, however, an inherent ability to adapt to such a salinity fluctuation. Here, we investigated the dynamic metabolite alterations of two P. trituberculatus
- PMID 24655103
- Individualization of chronic hepatitis C treatment according to the host characteristics.
- Gatselis NK, Zachou K, Saitis A, Samara M, Dalekos GN.Author information Nikolaos K Gatselis, Kalliopi Zachou, Asterios Saitis, George N Dalekos, Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, 41110 Larissa, Greece.AbstractHepatitis C virus (HCV) infection is a global health problem that affects more than 170 million people worldwide. It is a major cause of cirrhosis and hepatocellular carcinoma, making the virus the most common cause of liver failure and transplantation. The standard-of-care treatment for chronic hepatitis C (CHC) has been changed during the last decade and direct acting antiviral drugs have already been used. Besides, understanding of the pathogenesis of CHC has evolved rapidly during the last years and now several host factors are known to affect the natural history and response to treatment. Recent genome-wide association studies have shown the important role of interleukin-28B and inosine triphosphatase in HCV infection. The present review article attempts to summarize the current knowledge on the role of host factors towards individualization of HCV treatment.
- World journal of gastroenterology : WJG.World J Gastroenterol.2014 Mar 21;20(11):2839-2853.
- Hepatitis C virus (HCV) infection is a global health problem that affects more than 170 million people worldwide. It is a major cause of cirrhosis and hepatocellular carcinoma, making the virus the most common cause of liver failure and transplantation. The standard-of-care treatment for chronic hep
- PMID 24659876
- Severe thrombocytopenia in a patient with inosine triphosphatase (ITPA)-CC genotype caused by pegylated interferon (IFN)-α-2a with ribavirin therapy: a case report.
- Jiang W, Hidaka H1, Nakazawa T, Kitagawa H, Koizumi W.Author information 1Department of Gastroenterology, Kitasato University School of Medicine, East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, Japan. hisashi7@kitasato-u.ac.jp.AbstractBACKGROUND: Pegylated interferon combined with ribavirin treatment is an effective therapy for chronic hepatitis C viral infection. However, pegylated interferon combined with ribavirin is associated with various adverse reactions. Severe thrombocytopenia is a life-threatening side effect of interferon therapy that can lead to bleeding. It is generally understood that the inosine triphosphatase-CC genotype does not have a significantly lower reduction by pegylated interferon combined with ribavirin in the mean platelet counts compared with the AA/CA genotype. We report a case of severe thrombocytopenia that developed in a patient with chronic hepatitis C treated with pegylated interferon combined with ribavirin in spite of having the inosine triphosphatase-CC genotype.
- BMC research notes.BMC Res Notes.2014 Mar 12;7(1):141. doi: 10.1186/1756-0500-7-141.
- BACKGROUND: Pegylated interferon combined with ribavirin treatment is an effective therapy for chronic hepatitis C viral infection. However, pegylated interferon combined with ribavirin is associated with various adverse reactions. Severe thrombocytopenia is a life-threatening side effect of interfe
- PMID 24621321
Japanese Journal
- C型慢性肝炎に対するPEG-IFN/RBV48週および72週投与の治療効果に関連するIL28BおよびITPA遺伝子多型の解析 (特集 C型肝炎個別化医療のための宿主因子,ウイルス因子)
- C型慢性肝炎治療に及ぼすIL28BおよびITPAの遺伝子多型とHCVウイルスゲノム変異の影響 (特集 C型肝炎個別化医療のための宿主因子,ウイルス因子)
- IL28B・ITPA遺伝子多型に基づいたPEG-IFN/RBV治療効果予測 (特集 C型肝炎治療の新たな展開)
Related Links
- inosine (I) [in´o-sēn] a purine nucleoside containing the base hypoxanthine and the sugar ribose, which occurs in transfer RNAs. inosine monophosphate (IMP) a nucleotide produced by removal of the amine group from adenosine ...
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