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1. 心不全患者における非心臓手術の麻酔 anesthesia for noncardiac surgery in patients with heart failure
2. 人工心肺（CPB）からの離脱 weaning from cardiopulmonary bypass cpb
3. 心停止または外傷性心臓損傷後の緊急手術のための麻酔 anesthesia for emergency surgery after cardiac arrest or traumatic cardiac injury
4. 高リスクの心血管疾患における出産および分娩時の麻酔：部位別 anesthesia for labor and delivery in high risk cardiovascular disease specific lesions

English Journal

Nieminen MS1, Buerke M2, Parissis J3, Ben-Gal T4, Pollesello P5, Kivikko M5, Karavidas A6, Severino P7, Comín-Colet J8, Wikström G9, Fedele F7.
International journal of cardiology.Int J Cardiol.2015 Nov 15;199:337-41. doi: 10.1016/j.ijcard.2015.07.049. Epub 2015 Jul 15.
INTRODUCTION: Heart failure places a significant economic burden on health care. Acute heart failure requires hospitalization and often frequent re-hospitalization in expensive wards where vasoactive rescue therapy is often added on top of standard medications. In these lean times, there is a growin
PMID 26241640

Repeated or intermittent levosimendan treatment in advanced heart failure: An updated meta-analysis.

Silvetti S1, Nieminen MS2.
International journal of cardiology.Int J Cardiol.2015 Aug 28;202:138-143. doi: 10.1016/j.ijcard.2015.08.188. [Epub ahead of print]
INTRODUCTION: Advanced heart failure is a malignant disease characterized by a debilitating late course, with increasingly frequent hospitalisations and high rate of mortality. Levosimendan, an inodilator developed for the treatment of acutely decompensated chronic heart failure, has been recently p
PMID 26386941

Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO--AE1--329 in the halothane-anesthetized dogs.

Nomura H1, Nakamura Y1, Cao X1, Honda A1, Katagi J1, Ohara H2, Izumi-Nakaseko H1, Satoh Y3, Ando K1, Sugiyama A4.
European journal of pharmacology.Eur J Pharmacol.2015 Aug 15;761:217-25. doi: 10.1016/j.ejphar.2015.06.012. Epub 2015 Jun 11.
Cardiovascular effects of a highly selective prostaglandin E2 type 4 (EP4) receptor agonist ONO-AE1-329 were assessed with the halothane-anesthetized dogs (n=6). ONO-AE1-329 was intravenously infused in three escalating doses of 0.3, 1 and 3ng/kg/min for 10min with a pause of 20min between the doses
PMID 26073024

Cardiovascular and Adenylate Cyclase Stimulating Effects of Colforsin Daropate, a Water-Soluble Forskolin Derivative, Compared With Those of Isoproterenol, Dopamine and Dobutamine

Yoneyama Masahiko,Sugiyama Atsushi,Satoh Yoshioki,Takahara Akira,Nakamura Yuji,Hashimoto Keitaro
Circulation journal : official journal of the Japanese Circulation Society 66(12), 1150-1154, 2002-11-20
Colforsin daropate is a recently developed water-soluble derivative of forskolin that directly stimulates adenylate cyclase, unlike the catecholamines. The chronotropic, inotropic and coronary vasodil …
NAID 110002666179

細野誠
日本薬理学雑誌 114(2), 83-88, 1999-08-01
… COL was a inodilator with positive inotropic and vasodilator effects and was effective on a β-receptor desensitized-heart model in which the effects of β-agonists and PDE inhibitors were attenuated. …
NAID 10005709121