出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/30 01:52:52」(JST)
Infant formula is a manufactured food designed and marketed for feeding to babies and infants under 12 months of age, usually prepared for bottle-feeding or cup-feeding from powder (mixed with water) or liquid (with or without additional water). The U.S. Federal Food, Drug, and Cosmetic Act (FFDCA) defines infant formula as "a food which purports to be or is represented for special dietary use solely as a food for infants by reason of its simulation of human milk or its suitability as a complete or partial substitute for human milk".[1]
Manufacturers state that the composition of infant formula is designed to be roughly based on a human mother's milk at approximately one to three months postpartum; however, there are significant differences in the nutrient content of these products.[2] The most commonly used infant formulas contain purified cow's milk whey and casein as a protein source, a blend of vegetable oils as a fat source, lactose as a carbohydrate source, a vitamin-mineral mix, and other ingredients depending on the manufacturer.[3] In addition, there are infant formulas using soybean as a protein source in place of cow's milk (mostly in the United States and Great Britain) and formulas using protein hydrolysed into its component amino acids for infants who are allergic to other proteins. An upswing in breastfeeding in many countries has been accompanied by a deferment in the average age of introduction of baby foods (including cow's milk), resulting in both increased breastfeeding and increased use of infant formula between the ages of 3- and 12-months.[4][5]
A 2001 World Health Organization (WHO) report found that infant formula prepared in accordance with applicable Codex Alimentarius standards was a safe complementary food and a suitable breast milk substitute. In 2003, the WHO and UNICEF published their Global Strategy for Infant and Young Child Feeding, which restated that "processed-food products for infants and young children should, when sold or otherwise distributed, meet applicable standards recommended by the Codex Alimentarius Commission", and also warned that "lack of breastfeeding—and especially lack of exclusive breastfeeding during the first half-year of life—are important risk factors for infant and childhood morbidity and mortality". In particular, the use of infant formula in less economically developed countries is linked to poorer health outcomes because of the prevalence of unsanitary preparation conditions, including lack of clean water and lack of sanitizing equipment.[6] UNICEF estimates that a formula-fed child living in unhygienic conditions is between 6 and 25 times more likely to die of diarrhea and four times more likely to die of pneumonia than a breastfed child.[7] Rarely, use of powdered infant formula (PIF) has been associated with serious illness, and even death, due to infection with Enterobacter sakazakii and other microorganisms that can be introduced to PIF during its production. Although E. sakazakii can cause illness in all age groups, infants are believed to be at greatest risk of infection. Between 1958 and 2006, there have been several dozen reported cases of E. sakazakii infection worldwide. The WHO believes that such infections are under-reported.[8]
Throughout history, mothers who could not breastfeed their babies either employed a wet nurse[9] or, less frequently, prepared food for their babies, a process known as "dry nursing".[9][10] Baby food composition varied according to region and economic status.[10] In Europe and America during the early 19th century, the prevalence of wet nursing began to decrease, while the practice of feeding babies mixtures based on animal milk rose in popularity.[11][12]
This trend was driven by cultural changes as well as increased sanitation measures,[13] and it continued throughout the 19th and much of the 20th century, with a notable increase after Elijah Pratt invented and patented the India-rubber nipple in 1845.[9][14] As early as 1846, scientists and nutritionists noted an increase in medical problems and infant mortality was associated with dry nursing.[11][15] In an attempt to improve the quality of manufactured baby foods, in 1867, Justus von Liebig developed the world's first commercial infant formula, Liebig's Soluble Food for Babies.[16] The success of this product quickly gave rise to competitors such as Mellin's Food, Ridge's Food for Infants and Nestlé's Milk.[17]
As physicians became increasingly concerned about the quality of such foods, medical recommendations such as Thomas Morgan Rotch's "percentage method" (published in 1890) began to be distributed, and gained widespread popularity by 1907.[9] These complex formulas recommended that parents mix cow's milk, water, cream, and sugar or honey in specific ratios to achieve the nutritional balance believed to approximate human milk reformulated in such a way as to accommodate the believed digestive capability of the infant.[4]
At the dawn of the 20th century in the United States, most infants were breastfed, although many received some formula feeding as well. Home-made "percentage method" formulas were more commonly used than commercial formulas in both Europe and the United States.[18] They were less expensive and were widely believed to be healthier. However, formula-fed babies exhibited more diet-associated medical problems, such as scurvy, rickets and bacterial infections than breastfed babies. By 1920, the incidence of scurvy and rickets in formula-fed babies had greatly decreased through the addition of orange juice and cod liver oil to home-made formulas. Bacterial infections associated with formula remained a problem more prevalent in the United States than in Europe, where milk was usually boiled prior to use in formulas.[18]
In the 1920s and 1930s, evaporated milk began to be widely commercially available at low prices, and several clinical studies suggested that babies fed evaporated milk formula thrive as well as breastfed babies[9][19]
These findings are not supported by modern research. These studies, accompanied by the affordable price of evaporated milk and the availability of the home icebox initiated a tremendous rise in the use of evaporated milk formulas.[4] By the late 1930s, the use of evaporated milk formulas in the United States surpassed all commercial formulas, and by 1950 over half of all babies in the United States were reared on such formulas.[9]
In parallel with the enormous shift (in industrialized nations) away from breastfeeding to home-made formulas, nutrition scientists continued to analyze human milk and attempted to make infant formulas that more closely matched its composition.[4] Maltose and dextrins were believed nutritionally important, and in 1912, the Mead Johnson Company released a milk additive called Dextri-Maltose. This formula was made available to mothers only by physicians. In 1919, milkfats were replaced with a blend of animal and vegetable fats as part of the continued drive to closer simulate human milk. This formula was called SMA for "simulated milk adapted."[9]
In the late 1920s, Alfred Bosworth released Similac (for "similar to lactation"), and Mead Johnson released Sobee.[9] Several other formulas were released over the next few decades, but commercial formulas did not begin to seriously compete with evaporated milk formulas until the 1950s. The reformulation and concentration of Similac in 1951, and the introduction (by Mead Johnson) of Enfamil (for "infant meal") in 1959 were accompanied by marketing campaigns that provided inexpensive formula to hospitals and pediatricians.[9] By the early 1960s, commercial formulas were more commonly used than evaporated milk formulas in the United States, which all but vanished in the 1970s. By the early 1970s, over 75% of American babies were fed on formulas, almost entirely commercially produced.[4]
When birth rates in industrial nations tapered off during the 1960s, infant formula companies heightened marketing campaigns in non-industrialized countries. Unfortunately, poor sanitation led to steeply increased mortality rates among infants fed formula prepared with contaminated (drinking) water.[20] Organized protests, the most famous of which was the Nestlé boycott of 1977, called for an end to unethical marketing. This boycott is ongoing, as the current coordinators maintain that Nestlé engages in marketing practices which violate the International Code of Marketing of Breast-milk Substitutes.
In addition to commercially marketed brands, generic brands (or store brands) of infant formula were introduced in the United States in 1997, first by PBM Products. These private label formulas are sold by many leading food and drug retailers such as Wal-Mart, Target, Kroger, Loblaws, and Walgreens. All infant formula brands in the United States are required to adhere to the Food and Drug Administration (FDA) guidelines. As reported by the Mayo Clinic: “as with most consumer products, brand-name infant formulas cost more than generic brands. But that doesn't mean that brand-name [Similac, Nestle, Enfamil] formulas are better. Although manufacturers may vary somewhat in their formula recipes, the FDA requires that all formulas contain the same nutrient density.”[21]
Similarly, in Canada all infant formulas regardless of brand are required to meet standards set by Health Canada.[22]
Follow-on or toddler formulas are sold for ages 6 months to 2 years, (when infants are typically breastfed) and are not nutritionally complete nor subject to the same regulations as infant formula. Critics have argued that follow-on and toddler formulas were introduced to circumvent the regulations regarding infant formula and have resulted in confusing advertising.[23]
An early example of follow-on formula was introduced by Wyeth in the Philippines in 1987, following the introduction in this country of regulations on infant formula advertising, but which did not address follow-on formulas (products that did not exist at the time of their drafting).[24] Similarly, while infant formula advertising is illegal in the United Kingdom, follow-on formula advertising is legal, and the similar packaging and market results in follow-on advertisements frequently being interpreted as advertisements for formula.[23] (See also industry and marketing, below.)
These products have also recently fallen under criticism for contributing to the childhood obesity epidemic in some developed countries due to their marketing and flavoring practices.[25]
Since the early 1970s, industrial countries have witnessed a resurgence in breastfeeding among newborns and infants to 6 months of age.[5] This upswing in breastfeeding has been accompanied by a deferment in the average age of introduction of other foods (such as cow's milk), resulting in increased use of both breastfeeding and infant formula between the ages of 3–12 months.[4][5]
The global infant formula market has been estimated at $7.9 billion,[26] with North America and Western Europe accounting for 33% of the market and considered largely saturated, and Asia representing 53% of the market.[27] South East Asia is a particularly large fraction of the world market relative to its population.[27] Infant formula is the largest segment of the baby food market,[27] with the fraction given as between 40%[27] and 70%.[26]
Leading health organizations (e.g. WHO, U.S. Centers for Disease Control and Department of Health and Human Services) are attempting to reduce the use of infant formula and increase the prevalence of breastfeeding from birth through 12 to 24 months of age through public health awareness campaigns.[28][29][30][31] The specific goals and approaches of these breastfeeding promotion programs, and the policy environment surrounding their implementation, vary by country. As a policy basic framework, the International Code of Marketing of Breast-milk Substitutes, adopted by the WHO's World Health Assembly in 1981, requires infant formula companies to preface their product information with statements that breastfeeding is the best way of feeding babies and that a substitute should only be used after consultation with health professionals.[32] The Baby Friendly Hospital Initiative also restricts use by hospitals of free formula or other infant care aids provided by formula companies. (See also Policy section below.)
Infant formulas come in powder, liquid concentrate, and ready-to-feed forms. They are designed to be prepared by the parent or caregiver in small batches and fed to the infant, usually with either a cup, as recommended by the WHO,[6] or a baby bottle.
Infant formulas also come in a variety of types:
Hypoallergenic formulas, such as those containing free individual amino acids, and sometimes referred to as elemental infant formula, are considered to reduce the likelihood of certain medical complications in babies with specific health problems, such as severe allergies to cow's milk and soy. Made of purely synthetic monomeric amino acids, they are often considered quite foul-tasting, and it is not uncommon for infants to reject elemental formulas after having been established on a sweeter-tasting regular formula.[citation needed]
Manufacturers and health officials advise it is very important to measure powders or concentrates accurately to achieve the intended final product concentration; otherwise, the child will be malnourished. It is advisable that all equipment that comes into contact with the infant formula be cleaned and sterilized before each use. Proper refrigeration is essential for any infant formula which is prepared in advance.
In developing countries, formula is frequently prepared improperly, resulting in high infant mortality due to malnutrition and diseases such as diarrhea and pneumonia. This is due to lack of clean water, lack of sterile conditions, lack of refrigeration, illiteracy (so written instructions cannot be followed), poverty (diluting formula so that it lasts longer), and lack of education of mothers by formula distributors. These problems and resulting disease and death are a key factor in opposition to the marketing and distribution of infant formula in developing countries by numerous public health agencies and NGOs (discussed in more detail at Nestlé boycott and International Code of Marketing of Breast-milk Substitutes).
Besides breast milk, infant formula is the only other milk product which the medical community considers nutritionally acceptable for infants under the age of one year (as opposed to cow's milk, goat's milk, or follow-on formula). Supplementing with solid food in addition to breast milk or formula begins during weaning, and most babies begin supplementing about the time their first teeth appear, usually around the age of six months.
Although cow's milk is the basis of almost all infant formula, plain cow's milk is unsuited for infants because of its high casein content and low whey content, which may put a strain on an infant's immature kidneys, and untreated cow's milk is not recommended before the age of 12 months. The infant intestine is not properly equipped to digest non-human milk, and this may often result in diarrhea, intestinal bleeding and malnutrition.[35] To reduce the negative effect on the infant's digestive system, cow's milk used for formula undergoes processing to be made into infant formula. This includes steps to make protein more easily digestible and alter the whey-to-casein protein balance to one closer to human milk, the addition of several essential ingredients (often called "fortification", see below), the partial or total replacement of dairy fat with fats of vegetable or marine origin, etc.
The nutrient content of infant formula for sale in the United States is regulated by the Food and Drug Administration (FDA) based on recommendations by the American Academy of Pediatrics Committee on Nutrition. The following must be included in all formulas produced in the U.S.:[36]
Other commonly used ingredients:
In addition, formulas not made with cow's milk include biotin, choline, and inositol.
The use and marketing of infant formula has come under scrutiny. Breastfeeding, including exclusive breastfeeding for the first 6 months of life, is widely advocated as "ideal" for babies and infants, both by health authorities[6][31] — and accordingly in ethical advertising of infant formula manufacturers.[38]
Despite the recommendation that babies be exclusively breastfed for the first 6 months, less than 40% of infants below this age are exclusively breastfed worldwide.[39] The overwhelming majority of American babies are not exclusively breastfed for this period – in 2005 under 12% of babies were breastfed exclusively for the first 6 months,[31] with over 60% of babies of 2 months of age being fed formula,[40] and approximately one in four breastfed infants having infant formula feeding within two days of birth.[41]
Some studies have shown that use of formula can vary according to the parents' socio-economic status, ethnicity or other characteristics. For example, according to a research conducted in Vancouver, Canada, 82.9% of mothers breastfeed their babies at birth, but the number differed between Caucasians (91.6%) and non-Caucasians (56.8%), with the difference essentially attributed to marital status, education and family income.[42] In the United States, mothers of lower socio-economic status have been found less likely to breastfeed, although this may be partly related to adverse effects of government nutrition supplementation programs that provide subsidies for infant formula.[43]
In most cases, infant formula is used to avoid the discomforts of breast feeding (or expressing breast milk). These include the mother being the sole source of food for the infant, inconvenience involved with breastfeeding, working outside the home, physical discomforts (such as nipple pain), and changes in the shape of the breasts. In some cases, breastfeeding is medically contraindicated. These include:
Use of infant formula has been cited for numerous increased health risks. Studies have found infants in developed countries who consume formula are at increased risk for acute otitis media, gastroenteritis, severe lower respiratory tract infections, atopic dermatitis, asthma, obesity, type 1 and 2 diabetes, sudden infant death syndrome (SIDS), eczema and necrotizing enterocolitis when compared to infants who are breastfed.[67][68][69][70] Some studies have found an association between infant formula and lower cognitive development, including iron supplementation in baby formula being linked to lowered I.Q. and other neurodevelopmental delays;[71][72] however other studies have found no correlation.[67]
Health officials around the world have been on alert for melamine contamination in infant formula since the 2008 discovery of a massive case of melamine poisoning in China, where milk was deliberately adulterated with the chemical, leading to illnesses in more than 300,000 infants, including cases of acute kidney failure, and blamed for the deaths of at least six babies. Large quantities of melamine were added to watered-down milk to give it the appearance of having adequate protein levels.[73]
In November 2008, traces of melamine were reported to have been found by the U.S. Food and Drug Administration in infant formula sold in the United States made by the three main American firms[74][75] — Abbott Laboratories, Nestle and Mead Johnson — responsible for 90–99% of the infant formula market in that country.[43][74] The levels were much less than those reported in China, where levels of melamine contamination had reached as much as 2,500 parts per million, about 10,000 times higher than the recorded US levels. The safety data sheet for melamine (CAS registry number 108-78-1; C3-H6-N6) recorded the acute oral toxicity (median lethal dose) at 3161 mg/kg (3161 ppm) for a rat.
Health Canada conducted a separate test and also detected traces of melamine in infant formula available in Canada. The melamine levels were well below Health Canada's safety limits,[76] although concerns remain about the safety of manufactured food for infants and monitoring of potentially dangerous substances.[73]
The policy, regulatory and industry environments surrounding the infant formula market vary tremendously between countries.
The International Code of Marketing of Breast-milk Substitutes is an international health policy framework adopted by the World Health Assembly of the WHO in 1981 regarding infant formula marketing, including strict restrictions on advertising.[32] Its implementation depends on the laws of different countries and the behavior of infant formula manufacturers – the code has no power itself. Legislation and corporate behavior vary significantly between countries: at least 65 countries have enacted national legislation implementing all or many of the provisions of the Code;[83] whereas elsewhere neither the Code nor its principles are followed by governments or formula manufacturers.
Practices that are banned in the Code include most advertising, claiming health benefits for formula, and giving free samples to women able to breastfeed – this latter practice is particularly criticized because it can interfere with lactation, creating dependence on formula. In many countries free samples of infant formula have been provided to hospitals for decades; infant formula is often the only product routinely provided free of charge to hospitals.[84] The Baby Friendly Hospital Initiative aims to reduce and eliminate this controversial practice.
Infant formula is one of the top three consumer commodities in the Philippines, and among the most imported products.[85] Annual sales amount to some US$469 million annually. US$88 million is spent on advertising the product.[86]
Infant formula marketing has been regulated since the 1987 Executive Order 51 or "Milk Code",[24] which regulated, but did not ban, practices such as advertising and providing free samples. Shortly after it was enacted, Wyeth introduced "follow-on formula", which was not in the purview of the Milk Code which predated its market entry.
In 2006, the Department of Health banned the advertising of infant formula and the practice of providing free samples, regardless of intended age group (in the Revised Implementing Rules and Regulations of Executive Order 51, or RIRR).[87] The new regulation was challenged by the infant formula industry in the Supreme Court. Initially the challenge was dismissed, but this decision was reversed following industry pressure and a controversial letter by American business leader Thomas Donahue,[88] then President and CEO of the US Chamber of Commerce, resulting in the regulation being suspended and advertising continuing.[24][85][87][89]
In South Africa, there is a move towards plain packaging of infant formula[90] under R 991 of the Foodstuffs, Cosmetics and Disinfectants Act; as of 6 December 2013, Regulation 7 (Sale and Promotion) is force, whereas Regulations 2-6 (primarily with respect to labelling) are scheduled to come into force on 6 December 2014. One of the key requirements as per Regulation 3.1.A.iii is a conspicuous message stating “[t]his product shall only be used on the advice of a health professional”.
In the United Kingdom, infant formula advertising has been illegal since 1995,[91] but advertising for "follow-on formula" is legal, which has been cited as a loophole allowing advertising of similarly-packaged formula.[23]
In the United States, infant formula is both heavily marketed – the country has not adopted the Code, nor is it being systematically implemented by manufacturers for domestic marketing[92] – and even heavily subsidized by the government: at least one third of the American market is supported by the government,[26] with over half of infant formula sold in the country provided through the Special Supplemental Nutrition Program for Women, Infants and Children (known as WIC).[43]
According to surveys, over 70% of large U.S. hospitals dispense infant formula to all infants, a practice opposed by the American Academy of Pediatrics and in violation of the Code.[93] The Gerber Products Company began marketing its brand of infant formula directly to the public in October 1989, while the Carnation Company began marketing Good Start infant formula directly to the public in January 1991.[93]
Infant formula costs are a significant fraction of the WIC program costs: 21% post-rebate and 46% pre-rebate.[43] Formula manufacturers are granted a WIC monopoly in individual states.[43] Meanwhile breastfeeding rates are substantially lower for WIC recipients;[94] this is partly attributed to formula being free of charge to mothers in the WIC program, who are of lower socio-economic status.[43] Violations of federal policy have also been found in terms of infant formula company advertising using the WIC trademark, to reach both WIC and non-WIC participants.[94] In recent years WIC has been expanding its breastfeeding promotion strategies, including providing subsidies for clients who use milk banks.[95]
| Dates | Events |
|---|---|
| 1867 | A formula containing wheat flour, cow's milk, malt flour, and potassium bicarbonate was developed.[96] |
| 1915 | A powder form of infant formula was introduced, containing cow's milk, lactose, oleo oils, and vegetable oils.[96] |
| 1929 | Soy formula was introduced.[96] |
| 1935 | Protein was added because it was believed cow's milk protein content was lower than human milk protein content; protein at 3.3–4.0 g/100 kcal was added.[96] |
| 1959 | Iron fortification was introduced because a large amount of iron (~80%) is used to expand the red blood cell mass in a growing infant. Infants with birth weights between 1500 and 2500g require 2 mg/kg of iron per day. Infants with weights of less than 1500g require 4 mg/kg per day.[96][97] |
| 1962 | The whey:casein ratio was made similar to human milk because producers were aware that human milk contains a higher ratio of whey protein, and cow's milk contains a higher ratio of casein.[96] |
| 1984 | Taurine fortification was introduced because newborn infants lack the enzymes needed to convert and form taurine.[96][98] |
| Late 1990 | Nucleotide fortification was introduced into infant formula because nucleotides can act as growth factors and may enhance the infant immune system.[96] |
| Early 2000 | Polyunsaturated fatty acid fortification was introduced. Polyunsaturated fatty acids, such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), were added because those fatty acids play an important role in infant brain development.[96] |
The manufacturing process may differ for different types of formula made; therefore the following is the general procedure for liquid-milk based formulas:[36]
Primary ingredients are blended in large stainless steel tanks and skim milk is added and adjusted to 60 °C. Then, fats, oils and emulsifiers are added. Additional heating and mixing may be required to get proper consistency. Next, minerals, vitamins, and stabilizing gums are added at various points, depending on their sensitivity to heat. The batch is temporarily stored and then transported by pipelines to pasteurization equipment when mixing is complete.[36]
This is a process that protects against spoilage by eliminating bacteria, yeasts and molds. It involves quickly heating and then cooling of the product under controlled conditions which micro-organisms cannot survive. The batch is held at around 85–94 °C for approximately 30 seconds which is necessary to adequately reduce micro-organisms and prepare the formula for filling.[36]
This is a process which increases emulsion uniformity and stability by reducing size of fat and oil particles in the formula. It is done with a variety of mixing equipment that applies shear to the product and this mixing breaks fat and oil particles into very small droplets.[36]
Standardization is used to ensure that the key parameters like pH, fat concentration and vitamins and mineral content are correct. If insufficient levels of these are found, the batch is reworked to achieve appropriate levels. After this step, the batch is ready to be packaged.[36]
Packaging depends on manufacturer and type of equipment used, but in general, liquid formula is filled into metal cans with lids crimped into place.[36]
Finally, infant formulas are heat treated to maintain the bacteriologic quality of the product. This can be done traditionally by either retort sterilization or high-temperature short-time (HTST) treatment. Recently, ultrahigh-temperature treated formula has become more commonly used. If powdered formula is made, then spray drying would be required in addition.[99] Retort sterilization is a traditional retort sterilization method that uses 10-15mins treatment at 118 °C.[99] Ultrahigh-temperature (UHT) is a method that uses a brief (2–3 seconds) treatment at 142 °C. Because of the short time used, there is little protein denaturation, but the process still ensures sterility of the final product.[99]
Recently, probiotics have become a new ingredient in many of our foods, and studies have been completed regarding the use of probiotics in infant formula[100] Several randomized, controlled trials completed recently have shown limited and short term clinical benefits for the use of probiotics in infants’ diet[100] The safety of probiotics in general and in infants, especially preterm infants, has been investigated in a limited number of controlled trials. The findings thus far suggest probiotics are generally safe.[100] Therefore, the study suggested more scientific research is necessary before a conclusion can be made about probiotic supplementation in infant formula, since the research is still quite preliminary.[100]
Prebiotics are undigestible carbohydrates that promote the growth of probiotic bacteria in the gut. Human milk contains a variety of oligosaccharides believed to be an important factor in the pattern of microflora colonization of breastfed infants. Because of variety, variability, complexity and polymorphism of the oligosaccharide composition and structure, it is currently not feasible to reproduce the oligosaccharide components of human milk in a strictly structural fashion.[101]
The European Society of Pediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition found evidence to support short term effects of ingesting prebiotics on stool microflora of infants with increased in the number of bifidobacteria. Babies can be at risk of dehydration with the induction of softer stools, if they have the kidney immaturity and/or a poor ability to concentrate urine.[101] A reduction of pathogens has been associated with the consumption of prebiotics.[101] However, there was no evidence to support major clinical or long-term benefits.[100] Therefore, there is little evidence of beneficial effects of prebiotics in dietary products.[100]
Lysozyme is an enzyme that is responsible for protecting the body by damaging bacterial cell walls. Lactoferrin is a globular, multifunctional protein that has antimicrobial activity. Compared to human milk, cow’s milk has a signifactly lower levels of lysozyme and lactoferrin; therefore, the industry has an increasing interest in adding them into infant formulas.[96]
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