WordNet
- any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
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- 酵素
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/16 14:01:11」(JST)
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An adaptive enzyme or inducible enzyme is an enzyme that is expressed only under conditions in which it is clear of adaptive value, as opposed to a constitutive enzyme which is produced all the time. The Inducible enzyme is used for the breaking-down of things in the cell. It is also a part of the Operon Model, which illustrates a way for genes to turn "on" and "off". The Inducer causes the gene to turn on (controlled by the amount of reactant which turns the gene on). Then there's the repressor protein that turns genes off. The inducer can remove this repressor, turning genes back on. The operator is a section of DNA where the repressor binds to shut off certain genes; the promoter is the section of DNA where the RNA polymerase binds. Lastly, the regulatory gene is the gene for the repressor protein. An example of inducible enzyme is COX-2 which is synthesized in macrophages to produce Prostaglandin E2 while the constitutive enzyme COX-1 (another isozyme in COX family) is always produced in variety of organisms in body (like stomach).
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English Journal
- Enzyme-mediated nutrient release: glucose-precursor activation by β-galactosidase to induce bacterial growth.
- Karton-Lifshin N, Vogel U, Sella E, Seeberger PH, Shabat D, Lepenies B.SourceSchool of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences and Tel Aviv University, Tel Aviv, 69978, Israel. chdoron@post.tau.ac.il.
- Organic & biomolecular chemistry.Org Biomol Chem.2013 May 7;11(17):2903-10. doi: 10.1039/c3ob27385g. Epub 2013 Mar 21.
- Bacteria will gain an advantage if they are able to metabolize nutrients that are inaccessible for other bacteria. To demonstrate this principle, we developed a simple model system, which mimics how bacteria exploit natural carbon sources. A masked glucose precursor that is activated by β-galactosi
- PMID 23519143
- Towards a metabolic engineering strain "commons": An Escherichia coli platform strain for ethanol production.
- Woodruff LB, May BL, Warner JR, Gill RT.SourceDepartment of Chemical and Biological Engineering, University of Colorado at Boulder, Jennie Smoly Caruthers Biotechnology Building, UCB 596, Boulder, Colorado 80309; telephone: 303-492-2627; fax: 303-492-8425.
- Biotechnology and bioengineering.Biotechnol Bioeng.2013 May;110(5):1520-6. doi: 10.1002/bit.24840. Epub 2013 Jan 29.
- In the genome-engineering era, it is increasingly important that researchers have access to a common set of platform strains that can serve as debugged production chassis and the basis for applying new metabolic engineering strategies for modeling and characterizing flux, engineering complex traits,
- PMID 23322646
- Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy.
- Wilkinson-Berka JL, Rana I, Armani R, Agrotis A.SourceDepartment of Immunology, Central Clinical School, Monash University, 99 Commercial Road, Alfred Medical Research and Education Precinct (AMREP), Alfred Centre, Melbourne, Victoria 3004, Australia. Jennifer.wilkinson-berka@monash.edu
- Clinical science (London, England : 1979).Clin Sci (Lond).2013 May;124(10):597-615. doi: 10.1042/CS20120212.
- Pathological angiogenesis is a key feature of many diseases including retinopathies such as ROP (retinopathy of prematurity) and DR (diabetic retinopathy). There is considerable evidence that increased production of ROS (reactive oxygen species) in the retina participates in retinal angiogenesis, al
- PMID 23379642
Japanese Journal
- 生体タンパク質との非特異的な相互作用を介した食品成分の機能性発現機構
- 村上 明
- 薬学雑誌. 乙号 135(1), 47-55, 2015
- … On the other hand, zerumbone markedly suppressed the expression of cyclooxygenase-2, an inducible pro-inflammatory enzyme, by disrupting mRNA stabilizing processes. …
- NAID 130004756454
- Resveratrol Suppresses the Inducible Expression of CYP3A4 Through the Pregnane X Receptor
- Deng Rongrong,Xu Chenshu,Chen Xiao,Chen Pan,Wang Yongtao,Zhou Xunian,Jin Jing,Niu Lu,Ying Mengjia,Huang Min,Bi Huichang
- Journal of Pharmacological Sciences 126(2), 146-154, 2014
- … The inducible expression of several important cytochrome P450 (CYP450) enzymes has been shown to be regulated by the activation of PXR in the liver. … Treatment of hPXR-over-expressed cells with RES reduced the rifampicin-inducible expression of CYP3A4 in a concentration-dependent manner. … Taking together, these findings suggest that RES can attenuate the PXR-mediated induction of CYP3A enzyme. …
- NAID 130004700278
- Cynandione A from Cynanchum wilfordii Attenuates the Production of Inflammatory Mediators in LPS-Induced BV-2 Microglial Cells via NF-κB Inactivation
- Yang Seung Bo,Lee Sang Min,Park Ji-Hae,Lee Tae Hoon,Baek Nam-In,Park Hi-Joon,Lee Hyejung,Kim Jiyoung
- Biological and Pharmaceutical Bulletin 37(8), 1390-1396, 2014
- … In the present study, we isolated cynandione A (CA) from an extract of Cynanchum wilfordii roots (CWE) and investigated the effects of CA on the expression of inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines in lipopolysaccharide (LPS)-induced BV-2 microglial cells. …
- NAID 130004677529
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★リンクテーブル★
[★]
- 英
- inducible enzyme
- 関
- 適応酵素、酵素誘導、ペニシリナーゼ
[★]
- 関
- inducibly、inductive、provocative