indoleamine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/31 13:42:29」(JST)

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Tryptamine - otherwise known as indolamine.

Indolamines are a family of neurotransmitters that share a common molecular structure (namely, indolamine). Indolamines are a classification of monoamine neurotransmitter, along with catecholamines and ethylamine. A common example of an indolamine is serotonin, a neurotransmitter involved in mood and sleep. Another example of an indolamine is melatonin, which regulates the sleep-wake cycle (circadian rhythm) in humans.

In biochemistry, indolamines are substituted indole compounds that contain an amino group. Examples of indoleamines include the lysergamides.

Synthesis

The pathway for the synthesis of serotonin from tryptophan. Note that all compounds shown are indolamines.

In humans, neurotransmitters in the indolamine family are believed to be produced in the pineal gland. Indolamines are biologically synthesized from the essential amino acid tryptophan. Tryptophan is synthesized into serotonin through the addition of a hydroxyl group by the enzyme tryptophan hydroxylase and the subsequent removal of the carboxyl group by the enzyme 5-HTP decarboxylase.

See also

• Indole
• Tryptamine

References

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• Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.

• Ni H1, Sun Q1, Tian T1, Feng X1, Sun BL2.
• Molecular medicine reports.Mol Med Rep.2015 Aug;12(2):2727-34. doi: 10.3892/mmr.2015.3691. Epub 2015 Apr 28.
• Despite the effective use of antiepileptic drugs (AEDs) for epilepsy, therapeutic failure occurs in 30% of patients. Novel approaches are targeting the inhibition of epileptogenesis. N‑acetyl‑5‑methoxytryptamine (melatonin) is an indoleamine produced mainly by the pineal gland, and has been ob
• PMID 25937089

• Impact of immunosuppressive agents on the expression of indoleamine 2,3-dioxygenase, heme oxygenase-1 and interleukin-7 in mesangial cells.

• Liang GB1, Luo GH2, Bao DS1, Chen AJ1, Zhuang YX1, Guo YN1, Wang X1, Wang YL1, Chen ZP1, Lu YP3, Li YP4.
• Molecular medicine reports.Mol Med Rep.2015 Aug;12(2):2577-83. doi: 10.3892/mmr.2015.3713. Epub 2015 May 4.
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Japanese Journal

• 造血器疾患の予後因子としての Indoleamine 2, 3-dioxygenase (IDO)

• 原 武志,鶴見 寿
• 臨床病理 59(12), 1133-1143, 2011-12-25
• NAID 10030462971

• Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer

• HUANG Tzu-Ting,YEN Meng-Chi,LIN Chi-Chen,WENG Tzu-Yang,CHEN Yi-Ling,LIN Chiu-Mei,LAI Ming-Derg
• Cancer science 102(12), 2214-2220, 2011-12-10
• NAID 10030246086

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