関: indigotindisulfonate sodium

WordNet

having a color between blue and violet; "indigo flowers"
deciduous subshrub of southeastern Asia having pinnate leaves and clusters of red or purple flowers; a source of indigo dye (同)indigo plant, Indigofera tinctoria
a blue-violet color
color carmine

PrepTutorEJDIC

〈C〉(一年生植物の)アイ / 〈U〉藍(あい)色,紺色 / 藍色の,紺色の
洋紅色(紫がかった深紅色) / 洋紅色の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/13 14:45:47」(JST)

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Indigo carmine, or 5,5'-indigodisulfonic acid sodium salt, also known as indigotine or FD&C Blue #2 is a pH indicator with the chemical formula C₁₆H₈N₂Na₂O₈S₂. It is approved for use as a food colorant in the United States^[1] and in Europe.^[2] and has the E number E132.

Uses

Indigo Carmine (pH indicator)
below pH 11.4		above pH 13.0
11.4	⇌	13.0

Indigo carmine is commonly used as a pH indicator, often in a 0.2% aqueous solution. It is blue at pH 11.4 and yellow at 13.0. Indigo carmine is also a redox indicator, turning yellow upon reduction. Another use is as a dissolved ozone indicator^[3] through the conversion to isatin-5-sulfonic acid.^[3] This reaction has been shown not to be specific to ozone, however: it also detects superoxide, an important distinction in cell physiology.^[4] It is also used as a dye in the manufacturing of capsules.

In obstetric surgery, indigo carmine solutions are sometimes employed to detect amniotic fluid leaks. In urologic surgery, intravenous injection of indigo carmine is often used to highlight portions of the urinary tract. The dye is filtered rapidly by the kidneys from the blood, and colors the urine blue. This enables structures of the urinary tract to be seen in the surgical field, and demonstrate if there is a leak. However, the dye can cause a potentially dangerous increase in blood pressure in some cases.^[5]

Health concerns

Indigo carmine is harmful to the respiratory tract if inhaled. It is also an irritant to the skin and eyes. Proper laboratory cautions (lab coat, gloves, goggles) are advised.

References

^ Summary of Color Additives for Use in United States in Foods, Drugs, Cosmetics, and Medical Devices, United States Food and Drug Administration
^ Current EU approved additives and their E Numbers, Food Standards Agency, 26 November 2010
^ ^a ^b Takeuchi K, Ibusuki T (March 1989). "Quantitative determination of aqueous-phase ozone by chemiluminescence using indigo-5,5'-disulfonate". Anal. Chem. 61 (6): 619–23. doi:10.1021/ac00181a025. PMID 2729594.
^ Kettle AJ, Clark BM, Winterbourn CC (April 2004). "Superoxide converts indigo carmine to isatin sulfonic acid: implications for the hypothesis that neutrophils produce ozone". J. Biol. Chem. 279 (18): 18521–5. doi:10.1074/jbc.M400334200. PMID 14978029.
^ Craik, Johnathan Donaldson (January–February 2009). "The Safety of Intravenous Indigo Carmine to Assess Ureteric Patency During Transvaginal Uterosacral Suspension of the Vaginal Vault". Journal of Pelvic Medicine & Surgery 15 (1): 11–15. doi:10.1097/SPV.0b013e3181986ace. Retrieved 18 October 2012.

http://physchem.ox.ac.uk/MSDS/IN/indigo_carmine.html
http://hazard.com/msds/mf/baker/baker/files/i1440.htm

UpToDate Contents

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1. 色素内視鏡検査 chromoendoscopy
2. 婦人科外科手術における尿路損傷：評価およびマネージメント urinary tract injury in gynecologic surgery evaluation and management
3. 婦人科疾患についての診断的膀胱尿道鏡検査 diagnostic cystourethroscopy for gynecologic conditions
4. 診断的羊水穿刺 diagnostic amniocentesis
5. 拡大内視鏡検査 magnification endoscopy

English Journal

Use of indigo carmine angiography to qualitatively assess adequate distal perfusion after endovascular revascularization in critical limb ischemia.

Higashimori A1, Yokoi Y2.
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists.J Endovasc Ther.2015 Jun;22(3):352-5. doi: 10.1177/1526602815582208. Epub 2015 Apr 17.
PURPOSE: To report a novel technique to visualize the efficacy of revascularization in critical limb ischemia patients with ischemic foot ulcers.TECHNIQUE: An 80-year-old man was admitted with nonhealing ulcers on his left second toe and lateral border of the foot owing to in-stent restenosis of the
PMID 25887729

The layered double hydroxide route to Bi-Zn co-doped TiO₂ with high photocatalytic activity under visible light.

Benalioua B1, Mansour M1, Bentouami A2, Boury B3, Elandaloussi el H1.
Journal of hazardous materials.J Hazard Mater.2015 May 15;288:158-67. doi: 10.1016/j.jhazmat.2015.02.013. Epub 2015 Feb 7.
In this work, a co-doped Bi-Zn-TiO₂ photocatalist is synthesized by an original synthesis route of layered double hydroxide followed by heat treatment at 670 °C. After characterization the photocatalyst efficiency is estimated by the photo-discoloration of an anionic dye (indigo carmine) under vi
PMID 25699677

A novel microfluidic approach for extremely fast and efficient photochemical transformations in fluoropolymer microcapillary films.

Reis NM1, Li Puma G.
Chemical communications (Cambridge, England).Chem Commun (Camb).2015 May 5;51(40):8414-7. doi: 10.1039/c5cc01559f.
The unique optical properties of the fluoropolymer microcapillary film (MCF) material combined with the extremely fast photoinactivation of Herpes HSV-1 virus, and photodegradation of indigo carmine, diclofenac and benzoylecgonine in the MCF array photoreactor, demonstrate a new, flexible and inexpe
PMID 25849647

Japanese Journal

脊髄動静脈瘻の直達手術 : 選択的色素動注法による手術支援

永田崇,高見俊宏,三橋豊,下川宣幸,森迫拓貴,山本直樹,西尾明正,大畑建治
脊髄外科 : 日本脊髄外科研究会機関誌 = Spinal surgery : official journal of the Japanese Society of Spinal Surgery 24(1), 57-62, 2010-06-01
NAID 10026471669

小型マルクス回路を用いた水中放電による水浄化の検討

清水一男,BLAJAN Marius,村松秀一
電気学会論文誌. A, 基礎・材料・共通部門誌 = The transactions of the Institute of Electrical Engineers of Japan. A, A publication of Fundamentals and Materials Society 130(6), 531-537, 2010-06-01
… The discoloration of indigo carmine solution was carried out to investigate the feasibility of low voltage discharge in bubbling water. … As a result, indigo carmine solution was decolorized, although the discharge voltage was about -2.4 kV. …
NAID 10026382226

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リンク元	「indigotindisulfonate sodium」
関連記事	「indigo」「carmine」

「indigotindisulfonate sodium」

Indigo carmine
Names
	IUPAC name 3,3'-dioxo-2,2'-bis-indolyden-5,5'-disulfonic acid disodium salt
	Other names indigotine; 5,5'-indigodisulfonic acid sodium salt
Identifiers
ATC code	V04CH02
CAS Registry Number	860-22-0
ChemSpider	4447431
	InChI InChI=1S/C16H10N2O8S2.2Na/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14;;/h1-6,17-18H,(H,21,22,23)(H,24,25,26);;/q;2+1/p-2/b14-13+;; ; Key: KHLVKKOJDHCJMG-QDBORUFSSA-L ; InChI=1/C16H10N2O8S2.2Na/c19-15-9-5-7(27(21,22)23)1-3-11(9)17-13(15)14-16(20)10-6-8(28(24,25)26)2-4-12(10)18-14;;/h1-6,17-18H,(H,21,22,23)(H,24,25,26);;/q;2+1/p-2/b14-13+;;; Key: KHLVKKOJDHCJMG-AKPRSONXBD ;
Jmol-3D images	Image
PubChem	5284351
	SMILES [Na+].[Na+].[O-]S(=O)(=O)c3cc4C(=O)\C(=C2\C(=O)c1cc(ccc1N2)S([O-])(=O)=O)Nc4cc3 ;
UNII	D3741U8K7L
Properties
Chemical formula	C16H8N2Na2O8S2
Molar mass	466.36 g/mol
Appearance	purple solid
Melting point	>300 °C (572 °F)
Solubility in water	10 g/L (25 °C (77 °F))
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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	Infobox references