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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/08/27 01:03:29」(JST)
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Indenolol
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Names |
IUPAC name
1-(1H-Inden-4-yloxy)-3-(propan-2-ylamino)propan-2-ol
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Identifiers |
CAS Number
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60607-68-3 |
ChEMBL |
ChEMBL153585 |
ChemSpider |
64962 |
DrugBank |
DB08952 N |
EC Number |
262-323-5 |
Jmol 3D model |
Interactive image |
KEGG |
D08078 |
PubChem |
71955 |
InChI
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InChI=1S/C15H21NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3
Key: MPGBPFMOOXKQRX-UHFFFAOYSA-N
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InChI=1/C15H21NO2/c1-11(2)16-9-13(17)10-18-15-8-4-6-12-5-3-7-14(12)15/h3-4,6-8,11,13,16-17H,5,9-10H2,1-2H3
Key: MPGBPFMOOXKQRX-UHFFFAOYAY
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SMILES
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CC(C)NCC(COC1=CC=CC2=C1C=CC2)O
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Properties |
Chemical formula
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C15H21NO2 |
Molar mass |
247.34 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references |
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Indenolol is a beta-adrenergic blocker.[1]
References
- ^ Ali, I; Gaitonde, VD; Aboul-Enein, HY; Hussain, A (2009). "Chiral separation of beta-adrenergic blockers on CelluCoat column by HPLC". Talanta. 78 (2): 458–63. doi:10.1016/j.talanta.2008.11.043. PMID 19203609.
Adrenergics
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Receptor ligands
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α1 |
- Agonists
- 6-FNE
- Amidephrine
- Anisodine
- Buspirone
- Cirazoline
- Corbadrine
- Dexisometheptene
- Dipivefrine
- Dopamine
- Ephedrine
- Epinephrine
- Etilefrine
- Ethylnorepinephrine
- Indanidine
- Isometheptene
- Metaraminol
- Methoxamine
- Methyldopa
- Midodrine
- Naphazoline
- Norepinephrine
- Octopamine (drug)
- Oxymetazoline
- Phenylephrine
- Phenylpropanolamine
- Pseudoephedrine
- Synephrine
- Tetrahydrozoline
- Tiamenidine
- Xylometazoline
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- Antagonists
- Abanoquil
- Adimolol
- Ajmalicine
- Alfuzosin
- Amosulalol
- Anisodamine
- Arotinolol
- Atiprosin
- Atypical antipsychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)
- Benoxathian
- Buflomedil
- Bunazosin
- Carvedilol
- Corynanthine
- Dapiprazole
- Domesticine
- Doxazosin
- Ergolines (e.g., ergotamine, dihydroergotamine, lisuride, terguride)
- Etoperidone
- Eugenodilol
- Fenspiride
- Hydroxyzine
- Indoramin
- Ketanserin
- L-765,314
- Labetalol
- mCPP
- Mepiprazole
- Metazosin
- Monatepil
- Moxisylyte
- Naftopidil
- Nantenine
- Nefazodone
- Neldazosin
- Niaprazine
- Nicergoline
- Niguldipine
- Pardoprunox
- Pelanserin
- Phendioxan
- Phenoxybenzamine
- Phentolamine
- Piperoxan
- Prazosin
- Quinazosin
- Ritanserin
- Silodosin
- Spiperone
- Talipexole
- Tamsulosin
- Terazosin
- Tiodazosin
- Tolazoline
- Trazodone
- Tetracyclic antidepressants (e.g., amoxapine, maprotiline, mianserin)
- Tricyclic antidepressants (e.g., amitriptyline, clomipramine, doxepin, imipramine, trimipramine)
- Trimazosin
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Urapidil
- WB-4101
- Zolertine
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α2 |
- Agonists
- (R)-3-Nitrobiphenyline
- 4-NEMD
- 6-FNE
- Amitraz
- Apraclonidine
- Brimonidine
- Cannabivarin
- Clonidine
- Corbadrine
- Detomidine
- Dexmedetomidine
- Dihydroergotamine
- Dipivefrine
- Dopamine
- Ephedrine
- Ergotamine
- Epinephrine
- Etilefrine
- Ethylnorepinephrine
- Guanabenz
- Guanfacine
- Guanoxabenz
- Lofexidine
- Medetomidine
- Methamphetamine
- Methyldopa
- Mivazerol
- Naphazoline
- Norepinephrine
- Oxymetazoline
- Phenylpropanolamine
- Piperoxan
- Pseudoephedrine
- Rilmenidine
- Romifidine
- Talipexole
- Tetrahydrozoline
- Tiamenidine
- Tizanidine
- Tolonidine
- Urapidil
- Xylazine
- Xylometazoline
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- Antagonists
- 1-PP
- Adimolol
- Aptazapine
- Atipamezole
- Atypical antipsychotics (e.g., asenapine, clozapine, lurasidone, paliperidone, quetiapine, risperidone, zotepine)
- Azapirones (e.g., buspirone, tandospirone)
- BRL-44408
- Buflomedil
- Cirazoline
- Efaroxan
- Esmirtazapine
- Fenmetozole
- Fluparoxan
- Idazoxan
- mCPP
- Mianserin
- Mirtazapine
- NAN-190
- Olanzapine
- Pardoprunox
- Phentolamine
- Phenoxybenzamine
- Piperoxan
- Piribedil
- Rauwolscine
- Rotigotine
- SB-269970
- Setiptiline
- Spiroxatrine
- Sunepitron
- Tolazoline
- Typical antipsychotics (e.g., chlorpromazine, fluphenazine, loxapine, thioridazine)
- Yohimbine
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β |
- Agonists
- Abediterol
- Alifedrine
- Amibegron
- Arbutamine
- Arformoterol
- Arotinolol
- BAAM
- Bambuterol
- Befunolol
- Bitolterol
- Broxaterol
- Buphenine
- Carbuterol
- Carmoterol
- Cimaterol
- Clenbuterol
- Corbadrine
- Denopamine
- Dipivefrine
- Dobutamine
- Dopamine
- Dopexamine
- Ephedrine
- Epinephrine
- Etafedrine
- Etilefrine
- Ethylnorepinephrine
- Fenoterol
- Formoterol
- Hexoprenaline
- Higenamine
- Indacaterol
- Isoetarine
- Isoprenaline
- Isoxsuprine
- Levosalbutamol
- Mabuterol
- Methoxyphenamine
- Methyldopa
- Mirabegron
- Norepinephrine
- Orciprenaline
- Oxyfedrine
- PF-610355
- Phenylpropanolamine
- Pirbuterol
- Prenalterol
- Ractopamine
- Procaterol
- Pseudoephedrine
- Reproterol
- Rimiterol
- Ritodrine
- Salbutamol
- Salmeterol
- Solabegron
- Terbutaline
- Tretoquinol
- Tulobuterol
- Vilanterol
- Xamoterol
- Zilpaterol
- Zinterol
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- Antagonists
- Acebutolol
- Adaprolol
- Adimolol
- Afurolol
- Alprenolol
- Alprenoxime
- Amosulalol
- Ancarolol
- Arnolol
- Arotinolol
- Atenolol
- Befunolol
- Betaxolol
- Bevantolol
- Bisoprolol
- Bopindolol
- Bornaprolol
- Brefonalol
- Bucindolol
- Bucumolol
- Bufetolol
- Bufuralol
- Bunitrolol
- Bunolol
- Bupranolol
- Butaxamine
- Butidrine
- Butofilolol
- Capsinolol
- Carazolol
- Carpindolol
- Carteolol
- Carvedilol
- Celiprolol
- Cetamolol
- Cicloprolol
- Cinamolol
- Cloranolol
- Cyanopindolol
- Dalbraminol
- Dexpropranolol
- Diacetolol
- Dichloroisoprenaline
- Dihydroalprenolol
- Dilevalol
- Diprafenone
- Draquinolol
- Ecastolol
- Epanolol
- Ericolol
- Ersentilide
- Esatenolol
- Esprolol
- Eugenodilol
- Exaprolol
- Falintolol
- Flestolol
- Flusoxolol
- Hydroxycarteolol
- Hydroxytertatolol
- ICI-118,551
- Idropranolol
- Indenolol
- Indopanolol
- Iodocyanopindolol
- Iprocrolol
- Isoxaprolol
- Isamoltane
- Labetalol
- Landiolol
- Levobetaxolol
- Levobunolol
- Levomoprolol
- Medroxalol
- Mepindolol
- Metipranolol
- Metoprolol
- Moprolol
- Nadolol
- Nadoxolol
- Nebivolol
- Nifenalol
- Nipradilol
- Oxprenolol
- Pacrinolol
- Pafenolol
- Pamatolol
- Pargolol
- Penbutolol
- Pindolol
- Practolol
- Primidolol
- Procinolol
- Pronethalol
- Propafenone
- Propranolol
- Ridazolol
- Ronactolol
- Soquinolol
- Sotalol
- Spirendolol
- SR 59230A
- Sulfinalol
- Talinolol
- Tazolol
- Tertatolol
- Tienoxolol
- Tilisolol
- Timolol
- Tiprenolol
- Tolamolol
- Toliprolol
- Xibenolol
- Xipranolol
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Reuptake inhibitors
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NET |
- Selective norepinephrine reuptake inhibitors
- Amedalin
- Ciclazindol
- Daledalin
- Edivoxetine
- Esreboxetine
- Lortalamine
- Mazindol
- Nisoxetine
- Reboxetine
- Talopram
- Talsupram
- Tandamine
- Viloxazine
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- Norepinephrine-dopamine reuptake inhibitors
- Amineptine
- Bupropion
- Fencamine
- Fencamfamine
- Hydroxybupropion
- Lefetamine
- Levophacetoperane
- LR-5182
- Manifaxine
- Methylphenidate
- Nomifensine
- O-2172
- Radafaxine
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- Serotonin-norepinephrine reuptake inhibitors
- Atomoxetine (tomoxetine)
- Bicifadine
- BTS-54505
- Desvenlafaxine
- Duloxetine
- Eclanamine
- Levomilnacipran
- McN-5652
- Milnacipran
- N-Methyl-PPPA
- PPPA
- Sibutramine
- Venlafaxine
- WY-45233
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- Serotonin-norepinephrine-dopamine reuptake inhibitors
- (S)-Duloxetine
- 3,3-Diphenylcyclobutanamine
- Amifitadine
- Ansofaxine
- Bicifadine
- Brasofensine
- Centanafadine
- Cocaine
- Dasotraline
- Desmethylsertraline
- Diclofensine
- DOV-102677
- DOV-216303
- EXP-561
- Fezolamine
- HDMP-28
- Indatraline
- JNJ-7925476
- JZ-IV-10
- Liafensine
- Mazindol
- Naphyrone
- Nefazodone
- Nefopam
- NS-2359
- Perafensine
- PRC200
- SEP-228431
- SEP-228432
- Tedatioxetine
- Tesofensine
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- Tricyclic antidepressants
- Amitriptyline
- Butriptyline
- Cianopramine
- Clomipramine
- Desipramine
- Dosulepin
- Doxepin
- Imipramine
- Lofepramine
- Melitracen
- Nortriptyline
- Protriptyline
- Trimipramine
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- Tetracyclic antidepressants
- Amoxapine
- Maprotiline
- Mianserin
- Oxaprotiline
- Setiptiline
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- Others
- Antihistamines (e.g., brompheniramine, chlorphenamine, pheniramine, tripelennamine)
- Arylcyclohexylamines (e.g., ketamine, phencyclidine)
- CP-39,332
- EXP-561
- Fezolamine
- Ginkgo biloba
- Indeloxazine
- Loxapine
- Nefazodone
- Nefopam
- Opioids (e.g., methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)
- Pridefine
- Tedatioxetine
- Teniloxazine
- Tofenacin
- Tropanes (e.g., cocaine)
- Ziprasidone
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VMATs |
- Amiodarone
- Amphetamines (e.g., amphetamine, methamphetamine, MDMA)
- Bietaserpine
- Deserpidine
- Efavirenz
- GBR-12935
- Ibogaine
- Ketanserin
- Lobeline
- Reserpine
- Rose bengal
- Tetrabenazine
- Vanoxerine (GBR-12909)
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Releasing agents
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- Morpholines
- Fenbutrazate
- Fenmetramide
- Morazone
- Morforex
- Phendimetrazine
- Phenmetrazine
- Pseudophenmetrazine
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- Oxazolines
- 4-MAR
- Aminorex
- Clominorex
- Cyclazodone
- Fenozolone
- Fluminorex
- Pemoline
- Thozalinone
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- Phenethylamines (also amphetamines, cathinones, etc)
- 2-OH-PEA
- 4-CAB
- 4-FA
- 4-FMA
- 4-MA
- 4-MMA
- Alfetamine
- Amfecloral
- Amfepentorex
- Amfepramone
- Amphetamine
- Dextroamphetamine
- Levoamphetamine
- Amphetaminil
- β-Me-PEA
- BDB
- Benzphetamine
- BOH
- Buphedrone
- Bupropion
- Butylone
- Cathine
- Cathinone
- Clobenzorex
- Clortermine
- Dimethylamphetamine
- DMA
- DMMA
- EBDB
- Ephedrine
- Ethcathinone
- Ethylone
- Etilamfetamine
- Famprofazone
- Fenethylline
- Fenproporex
- Flephedrone
- Fludorex
- Furfenorex
- Hordenine
- 4-Hydroxyamphetamine
- 5-APDI (IAP)
- 5-MAPDI (IMP)
- Iofetamine (123I)
- Lisdexamfetamine
- Lophophine
- MBDB
- MDA
- MDEA
- MDMA
- Metamfepramone
- MDMPEA
- MDOH
- MDPEA
- Mefenorex
- Mephedrone
- Mephentermine
- Methamphetamine
- Dextromethamphetamine
- Levomethamphetamine
- Methcathinone
- Methedrone
- Methylone
- Morforex
- Naphthylaminopropane
- Ortetamine
- pBA
- pCA
- Pentorex
- Phenethylamine
- Pholedrine
- Phenpromethamine
- Phentermine
- Phenylpropanolamine
- pIA
- Prenylamine
- Propylamphetamine
- Pseudoephedrine
- Selegiline (also D-Deprenyl)
- Tiflorex
- Tyramine
- Xylopropamine
- Zylofuramine
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- Piperazines
- 2C-B-BZP
- BZP
- MBZP
- mCPP
- MDBZP
- MeOPP
- pFPP
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- Others
- 2-ADN
- 2-AI
- 2-AT
- 2-BP
- 4-BP
- 5-IAI
- Clofenciclan
- Cyclopentamine
- Cypenamine
- Cyprodenate
- Feprosidnine
- Gilutensin
- Heptaminol
- Hexacyclonate
- Indanorex
- Isometheptene
- Methylhexanamine
- Octodrine
- Phthalimidopropiophenone
- Propylhexedrine (Levopropylhexedrine)
- Tuaminoheptane
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Enzyme inhibitors
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PAH |
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TH |
- 3-Iodotyrosine
- Aquayamycin
- Bulbocapnine
- Metirosine
- Oudenone
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AAAD |
- Benserazide
- Carbidopa
- DFMD
- Genistein
- Methyldopa
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DBH |
- Bupicomide
- Disulfiram
- Dopastin
- Fusaric acid
- Nepicastat
- Phenopicolinic acid
- Tropolone
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PNMT |
- CGS-19281A
- SKF-64139
- SKF-7698
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MAO |
- Nonselective
- Benmoxin
- Caroxazone
- Echinopsidine
- Furazolidone
- Hydralazine
- Indantadol
- Iproclozide
- Iproniazid
- Isocarboxazid
- Isoniazid
- Linezolid
- Mebanazine
- Metfendrazine
- Nialamide
- Octamoxin
- Paraxazone
- Phenelzine
- Pheniprazine
- Phenoxypropazine
- Pivhydrazine
- Procarbazine
- Safrazine
- Tranylcypromine
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- MAO-A selective
- Amiflamine
- Bazinaprine
- Befloxatone
- Brofaromine
- Cimoxatone
- Clorgiline
- CX157 (Tyrima)
- Eprobemide
- Esuprone
- Harmala alkaloids
- Harmine
- Harmaline
- Tetrahydroharmine
- Harman
- Methylene blue
- Metralindole
- Minaprine
- Moclobemide
- Pirlindole
- Sercloremine
- Tetrindole
- Toloxatone
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- MAO-B selective
- Ladostigil
- Lazabemide
- Milacemide
- Mofegiline
- Pargyline
- Rasagiline
- Safinamide
- Selegiline (also D-Deprenyl)
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COMT |
- Entacapone
- Nitecapone
- Tolcapone
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Others
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Precursors |
- L-Phenylalanine → L-Tyrosine → L-DOPA (Levodopa) → Dopamine
- L-DOPS (Droxidopa)
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Cofactors |
- Ferrous Iron (Fe2+)
- S-Adenosyl-L-Methionine
- Vitamin B3 (Niacin
- Nicotinamide → NADPH)
- Vitamin B6 (Pyridoxine
- Pyridoxamine
- Pyridoxal → Pyridoxal Phosphate)
- Vitamin B9 (Folic acid → Tetrahydrofolic acid)
- Vitamin C (Ascorbic acid)
- Zinc (Zn2+)
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Neurotoxins |
- DSP-4
- Oxidopamine (6-OHDA)
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Others |
- Activity enhancers
- BPAP
- PPAP
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- Release blockers
- Bethanidine
- Bretylium
- Guanadrel
- Guanazodine
- Guanethidine
- Guanoxan
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- See also:
- Dopaminergics
- Melatonergics
- Serotonergics
- List of adrenergic drugs
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English Journal
- Enantio-separation of drugs with multiple chiral centers by chromatography and capillary electrophoresis.
- Al-Othman ZA1, Al-Warthan A, Alam SD, Ali I.
- Biomedical chromatography : BMC.Biomed Chromatogr.2014 Nov;28(11):1514-24. doi: 10.1002/bmc.3259. Epub 2014 Jul 28.
- Some drugs with more than one chiral center are of high medicinal values. However, the chiral resolution of such types of racemate is a challenging task for scientists. The evolution of efficient chiral selectors is a hope for the future. Some papers have described such types of chiral resolution. T
- PMID 25067822
- The pH sensitivity of -NH exchange in LnDOTA-tetraamide complexes varies with amide substituent.
- Opina AC1, Wu Y, Zhao P, Kiefer G, Sherry AD.
- Contrast media & molecular imaging.Contrast Media Mol Imaging.2011 Nov-Dec;6(6):459-64. doi: 10.1002/cmmi.445.
- The amide proton exchange rates in various lanthanide(III) DOTA-tetraamide complexes were investigated by CEST as a function of variable chemical structures and charges on the amide substituents. Comparisons were made between YbDOTA-(gly)(4)(-) (Yb-1), YbDOTA-(NHCH(2)PO(3))(4 (5-) (Yb-2) and YbDOTA-
- PMID 22144023
- Chiral separations of some beta-adrenergic agonists and antagonists on AmyCoat column by HPLC.
- Ali I1, Saleem K, Gaitonde VD, Aboul-Enein HY, Hussain I.
- Chirality.Chirality.2010 Jan;22(1):24-8. doi: 10.1002/chir.20697.
- Sixteen beta-adrenergic antagonists namely acebutalol, alprenolol, atenolol, bisoprolol, bopindolol, bufurolol, carazolol, celiprolol, indenolol, metaprolol, nebivolol, oxprenolol, practolol, propranolol, tertalol, and timolol, and two beta-adrenergic agonists namely cimeterol and clenbuterol were r
- PMID 19208401
Japanese Journal
- 音楽効果による歯科治療時の交感神経機能の抑制について
- 小池 一喜,吉川 圭一郎,原 和彦,篠崎 貴弘,深津 康仁,岡地 サユミ,柴田 典明,長谷川 和哉,大澤 一郎,松浦 信人,後藤 實,工藤 逸郎
- 日本歯科心身医学会雑誌 12(2), 169-174, 1997
- … It is known that the anxiety and sympathetically-medicated hypertension induced by dental procedures can be lessened by the hearing of music.<BR>In the present study, we measured the physiological effects of music-listening, especially on digital prethysm.ography (PTG) and the heat rate (HR), and compared them with the effects induced by the administration of indenolol hydrochloride, a β-blocker for pharmacological anti-stress treatment. … indenolol hydrochloride prior to the stress-inducing treatment. …
- NAID 130004307913
- 歯科治療時の交感神経活動に対する自律訓練法の抑制効果について(血中グルコース,遊離脂肪酸を指標として) (第2報)
- 小池 一喜,渡辺 幹夫,石川 精一,宮田 幸忠,原 邦嘉,後藤 實,押尾 英一,工藤 逸郎
- 日本歯科心身医学会雑誌 9(1), 75-79, 1994
- … Group 2: 8 subjects pre-treated with 10mg of a beta-blocker indenolol hydrochloride. … Group 2 was orally administered of 10mg indenolol hydrochloride, a first generation betablocker, one hour before injection into the oral cavity. …
- NAID 130004105575
- β-アドレナリン受容体遮断薬のβ-遮断作用,局所麻酔作用,膜安定化作用の効力の比較,並びに,Strophanthin-Gのモルモット心毒性発現に対する影響に関する研究
- 杉本 治良,湯浅 精一,鈴木 雅泰
- 関西医科大学雑誌 39(4), 418-429, 1987
- … The influence of alprenolol, carteolol, indenolol, pindolol, practolol, and propranolol on the effect of isoproterenol in isolated guinea-pig atrial contraction rate was examined comparing their beta-blocking actions, and their influence on the responses of guinea-pig cornea and dorsal skin to the mechanical stimulation was tested comparing their local anaesthetic actions. …
- NAID 130004701322
Related Links
- ChemicalBook あなたのためにINDENOLOL HCL(81789-85-7)の化学的性質を提供して、融点、価格、蒸気圧、沸点、毒性、比重、沸点、密度、分子式、分子量、物理的な性質、毒性 税関のコードなどの情報、同時にあなたは更に ...
- 1. Arch Int Pharmacodyn Ther. 1978 Jul;234(1):74-87. Effects of indenolol (YB-2), a new beta-adrenergic blocking agent, and its dextro isomer on the central nervous system of mice and rabbits. Tachikawa S, Takenaka T, Maeno H. ...
Related Pictures
★リンクテーブル★
[★]
- 英
- indenolol
- 化
- 塩酸インデノロール indenolol hydrochloride
- 同
- インデノロール
- 商
- プルサン
参考
- http://www.asahikawa-med.ac.jp/hospital/pharmacy/db/medis/2/2123003F2025.html
[★]
- 関
- indenolol