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English Journal

[Long-term and high-dose bisphosphonate administration causes no bone over-mineralization].

Liu C1, Cao YP, Yang X, Mashiba T, Mori S.
Zhonghua yi xue za zhi.Zhonghua Yi Xue Za Zhi.2009 Nov 17;89(42):2968-71.
OBJECTIVE: To evaluate the effects of long-term bisphosphonate administration (incadronate) upon the mean degree of secondary bone mineralization.METHODS: Thirty adult beagles were divided randomly into three groups of CNT, YML and YMH based upon their body weights (5 males and 5 females in each gro
PMID 20137705

Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogs.

Saito M1, Mori S, Mashiba T, Komatsubara S, Marumo K.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.Osteoporos Int.2008 Sep;19(9):1343-54. doi: 10.1007/s00198-008-0585-3. Epub 2008 Mar 29.
Collagen cross-linking is a determinant of bone quality. A three-year treatment of bisphosphonate-incadronate disodium-in beagles increased degree of mineralization, collagen maturity, and pentosidine, a compound with advanced glycation end products. The treatment had no effect on the total amount o
PMID 18373056

Bisphosphonate and low-dose dexamethasone treatment for patients with hormone-refractory prostate cancer.

Ueda T1, Suzuki H, Akakura K, Ishihara M, Kamiya N, Komiya A, Shimbo M, Suyama T, Sakamoto S, Ichikawa T.
Hinyokika kiyo. Acta urologica Japonica.Hinyokika Kiyo.2006 Jul;52(7):515-21.
We evaluated the effects of bisphosphonate (BP) treatment in five patients with hormone-refractory prostate cancer (HRPC), experiencing bone pain from metastases to the bone, and assessed changes in serum prostate specific antigen (PSA) levels, bone pain, and quality of life (QOL). Treatment with in
PMID 16910582

植田健,鈴木啓悦,赤倉功一郎
泌尿器科紀要 52(7), 515-521, 2006-07
… Treatment with incadronate disodium (10 mg) in saline was administered at 2-week intervals for a total of 6 times. …
NAID 120001159920