インシリコの、コンピュータでの、コンピュータシミュレーションによる
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/31 15:10:49」(JST)
in silico（イン・シリコ）は、in vivo （生体内で）や in vitro （ガラス、すなわち試験管内で）などに準じて作られた用語で、文字どおりには「シリコン内で」の意味であり、実際には「コンピュータを用いて」を意味する。バイオインフォマティクスなどの研究で頻繁に見られる表現である。
silico はシリコン（ケイ素）で、コンピュータの半導体にシリコンが使われていることからこのような表現になった。
分子生物学などの実験や測定は通常、ウェット (wet) と呼ばれるように細胞や各種の生体分子を実際に取り扱いながら行われる。それに対して、実験や測定に関連するシミュレーション計算など、実際に対象物を取り扱わず計算で結果を予測する手法を指して in silico と呼ぶ。
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In silico (literally Latin for "in silicon", alluding to the mass use of silicon for semiconductor computer chips) is an expression used to mean "performed on computer or via computer simulation." The phrase was coined in 1989 as an allusion to the Latin phrases in vivo, in vitro, and in situ, which are commonly used in biology (see also systems biology) and refer to experiments done in living organisms, outside of living organisms, and where they are found in nature, respectively.
In silico study in medicine is thought to have the potential to speed the rate of discovery while reducing the need for expensive lab work and clinical trials. One way to achieve this is by producing and screening drug candidates more effectively. In 2010, for example, using the protein docking algorithm EADock (see Protein-ligand docking), researchers found potential inhibitors to an enzyme associated with cancer activity in silico. Fifty percent of the molecules were later shown to be active inhibitors in vitro.[1][2] This approach differs from use of expensive high-throughput screening (HTS) robotic labs to physically test thousands of diverse compounds a day often with an expected hit rate on the order of 1% or less with still fewer expected to be real leads following further testing (see drug discovery).
Efforts have been made to establish computer models of cellular behavior. For example, in 2007 researchers developed an in silico model of tuberculosis to aid in drug discovery, with the prime benefit of being faster than real time simulated growth rates, allowing phenomena of interest to be observed in minutes rather than months.[3] More work can be found that focus on modeling a particular cellular process such as the growth cycle of Caulobacter crescentus.[4]
These efforts fall far short of an exact, fully predictive, computer model of a cell's entire behavior. Limitations in the understanding of molecular dynamics and cell biology as well as the absence of available computer processing power force large simplifying assumptions that constrain the usefulness of present in silico models.
Digital genetic sequences obtained from DNA sequencing may be stored in sequence databases, be analyzed (see Sequence analysis), be digitally altered and/or be used as templates for creating new actual DNA using artificial gene synthesis.
In silico computer-based modeling technologies have also been applied in:
The expression in silico was first used in public in 1989 in the workshop "Cellular Automata: Theory and Applications" in Los Alamos, New Mexico. Pedro Miramontes, a mathematician from National Autonomous University of Mexico (UNAM) presented the report "DNA and RNA Physicochemical Constraints, Cellular Automata and Molecular Evolution". In his talk, Miramontes used the term "in silico" to characterize biological experiments carried out entirely in a computer. The work was later presented by Miramontes as his PhD dissertation.[11]
In silico has been used in white papers written to support the creation of bacterial genome programs by the Commission of the European Community. The first referenced paper where "in silico" appears was written by a French team in 1991.[12] The first referenced book chapter where "in silico" appears was written by Hans B. Sieburg in 1990 and presented during a Summer School on Complex Systems at the Santa Fe Institute.[13]
The phrase "in silico" originally applied only to computer simulations that modeled natural or laboratory processes (in all the natural sciences), and did not refer to calculations done by computer generically.
"In silico" was briefly challenged by "in silicium," which is correct Latin for "in silicon". The Latin term for silicon, silicium, was created at the beginning of the 19th century by Berzelius. Silex, meaning flint, is a third declension Latin word in the nominative case, thus with the root silic- for the other cases, from which words like silica are derived in English. The phrase "in silice" means "in flint". However, the adjective in Latin meaning flint-like is silicius,a,um. Many names of elements with the ending -ium come from this adjectival form, e.g. calx (limestone), calcis (of limestone), calcium (limestone-like). In the end, "in silico" appears as an end rhyme on the words "in vivo" and "in vitro" making the word catchier based on similarity and not sounding odd to those who do not know the original classical languages. "In silico" is now widely recognized, and is used in a journal title -- In Silico Biology.[14]
Although the preposition in is Latin and en Greek, in silico is reasonable from the viewpoint of (ancient) Greek case endings; the "-on" ending for certain elements is from Greek. In Greek, "silicon" would take the form "silico" in such a phrase. Latin typically uses the correct Greek forms for Greek words when they are used with Latin prepositions.[citation needed]
Another possible reason for that preference is that English speakers find it easier to pronounce "in silico" than "in silicium".[citation needed]
| Look up in silico in Wiktionary, the free dictionary. |
| リンク元 | 「コンピュータ」「computer」「インシリコ」「コンピュータシミュレーション」「computer simulation」 |
| 関連記事 | 「In」 |