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1. アレルギー性鼻炎の免疫療法 immunologic treatments for allergic rhinitis
2. HIV感染成人におけるB型肝炎ウイルス感染の予防 prevention of hepatitis b virus infection in the hiv infected adult
3. 混合性結合組織病における抗U1-RNP抗体 anti u1 rnp antibodies in mixed connective tissue disease
4. HIV感染患者における予防接種 immunizations in hiv infected patients
5. 転移性前立腺癌に対する免疫療法 immunotherapy for metastatic prostate cancer

English Journal

Influence of molecular weight on in vitro immunostimulatory properties of instant coffee.

Passos CP1, Cepeda MR2, Ferreira SS2, Nunes FM3, Evtuguin DV4, Madureira P5, Vilanova M5, Coimbra MA2.
Food chemistry.Food Chem.2014 Oct 15;161:60-6. doi: 10.1016/j.foodchem.2014.03.119. Epub 2014 Apr 2.
Instant coffee was prepared and fractionated into higher (>100kDa), medium (5-10, 10-30, 30-100kDa) and lower (1-5, <1kDa) molecular weight fractions. Sugars and linkage composition characteristics of arabinogalactans and galactomannans were recovered in all fractions. Also, amino acid analysi
PMID 24837922

Partial characterization and immunostimulatory activity of exopolysaccharides from Lactobacillus rhamnosus KF5.

Shao L1, Wu Z2, Zhang H3, Chen W3, Ai L4, Guo B5.
Carbohydrate polymers.Carbohydr Polym.2014 Jul 17;107:51-6. doi: 10.1016/j.carbpol.2014.02.037. Epub 2014 Feb 20.
Lactobacillus rhamnosus KF5, a strain newly isolated from the faeces of a healthy human volunteer, has been shown to produce the exopolysaccharides (EPS) in skim milk. Two EPS fractions were separated from the fermented skim milk by removing proteins, ethanol precipitation, anion-exchange and gel pe
PMID 24702917

Microfluidic generation of chitosan/CpG oligodeoxynucleotide nanoparticles with enhanced cellular uptake and immunostimulatory properties.

Chen S1, Zhang H, Shi X, Wu H, Hanagata N.
Lab on a chip.Lab Chip.2014 Jun 7;14(11):1842-9. doi: 10.1039/c4lc00015c. Epub 2014 Apr 15.
Chitosan/cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN) nanoparticles as potential immunostimulatory adjuvants were synthesized by the conventional bulk mixing (BM) method and a novel microfluidic (MF) method. Their size and size distribution, CpG ODN loading efficiency, surface char
PMID 24733088

永田智
東京女子医科大学雑誌 85(2), 55-62, 2015-04-25
ヒトの腸管には、人体を構成する全細胞数をも凌ぐ実に100兆もの腸内細菌が棲息し、バランスを保ちながらヒトと共生関係を保っている。このバランスが乱れて、有害菌が多い腸内環境になってしまうと、便秘や下痢、各種感染症、アレルギーなどを起こしやすくなってくるといわれている。LactbacillusやBifidobacteriumのように、腸内細菌のバランスを改善することにより、宿主に有益な作用をもたらす生 …
NAID 110009900093

Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice.

Ishii-Mizuno Yumiko,Umeki Yuka,Takahashi Yuki,Kato Yukinori,Takabayashi Tetsuji,Fujieda Shigeharu,Takakura Yoshinobu,Nishikawa Makiya
Journal of controlled release 200, 52-59, 2015-02-28
… To develop an immunotherapeutic vaccine for treatment of allergic rhinitis, we developed a controlled release formulation of Cryj1, a major Japanese cedar pollen allergen, with immunostimulatory potency. … Two sets of hexapod-like structured DNA (hexapodna) were prepared using six oligodeoxynucleotides (ODNs) each, including ODNs with an unmethylated cytosine-phosphate-guanine (CpG) sequence (CpG motif), to obtain an immunostimulatory DNA hydrogel (sDNA hydrogel). …
NAID 120005540394

Studies of host-pathogen interactions and immune-related drug development using the silkworm: interdisciplinary immunology, microbiology, and pharmacology studies

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Drug Discoveries & Therapeutics advpub(0), 2015
… Moreover, we established an ex vivo system using silkworm larval specimens to quantitatively evaluate the immunostimulatory activity of natural compounds. …
NAID 130005064608