イムノフィリン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/01 16:56:09」(JST)
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In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases that interconvert [sic] between the cis and trans positions.
Immunophilins are targeted by immunosuppressive drugs such as sirolimus, cyclosporin, and tacrolimus. For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis-trans isomerization of peptide bonds, particularly X-Pro peptide bonds. This prolyl isomerase activity can be inhibited by immunosuppressive drugs.
See also
- FKBP12
- FKBP52
- FKBP5 = FKBP51
External links
- Immunophilins at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Plant immunophilins and signal transduction" at berkeley.edu
Transmembrane receptors: immunoglobulin superfamily immune receptors
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Antibody receptor:
Fc receptor |
Epsilon (ε) |
- FcεRI
- (FcεRII is C-type lectin)
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Gamma (γ) |
- FcγRI
- FcγRII
- FcγRIII
- Neonatal
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Alpha (α)/mu (μ) |
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Secretory |
- Polymeric immunoglobulin receptor
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Antigen receptor |
B cells |
Antigen receptor |
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Co-receptor |
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Accessory molecules |
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T cells |
Ligands |
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Antigen receptor |
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Co-receptors |
- CD8 (with two glycoprotein chains CD8α and CD8β)
- CD4
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Accessory molecules |
- CD3
- CD3γ
- CD3δ
- CD3ε
- ζ-chain (also called CD3ζ and TCRζ)
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Cytokine receptor |
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Killer-cell IG-like receptors |
- KIR2DL1
- KIR2DL2
- KIR2DL3
- KIR2DL4
- KIR2DL5A
- KIR2DL5B
- KIR2DS1
- KIR2DS2
- KIR2DS3
- KIR2DS4
- KIR2DS5
- KIR3DL1
- KIR3DL2
- KIR3DL3
- KIR3DS1
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Leukocyte IG-like receptors |
- LILRA1
- LILRA2
- LILRA3
- LILRA4
- LILRA5
- LILRA6
- LILRB1
- LILRB2
- LILRB3
- LILRB4
- LILRB5
- LILRA6
- LILRA5
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Isomerases: geometric (EC 5.2)
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5.2.1 |
- FKBP: FKBP1A
- FKBP1B
- FKBP2
- FKBP3
- FKBP5
- FKBP6
- FKBP8
- FKBP9
- FKBP10
- FKBP52
- FKBPL
- other: Cyclophilin
- Parvulin
- Prolyl isomerase
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Enzymes
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Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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English Journal
- Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.
- Li SJ1, Wang J1, Ma L2, Lu C1, Wang J1, Wu JW1,3, Wang ZX1,2.
- Cell research.Cell Res.2016 Mar;26(3):336-49. doi: 10.1038/cr.2016.14. Epub 2016 Jan 22.
- The Ca(2+)/calmodulin-dependent protein phosphatase calcineurin (CN), a heterodimer composed of a catalytic subunit A and an essential regulatory subunit B, plays critical functions in various cellular processes such as cardiac hypertrophy and T cell activation. It is the target of the most widely u
- PMID 26794871
- Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis.
- Warne J1, Pryce G2, Hill JM3, Shi X1, Lennerås F4, Puentes F4, Kip M1, Hilditch L5, Walker P6, Simone MI1, Chan AW1, Towers GJ5, Coker AR1, Duchen MR3, Szabadkai G7, Baker D8, Selwood DL9.
- The Journal of biological chemistry.J Biol Chem.2016 Feb 26;291(9):4356-73. doi: 10.1074/jbc.M115.700385. Epub 2015 Dec 17.
- The mitochondrial permeability transition pore is a recognized drug target for neurodegenerative conditions such as multiple sclerosis and for ischemia-reperfusion injury in the brain and heart. The peptidylprolyl isomerase, cyclophilin D (CypD, PPIF), is a positive regulator of the pore, and geneti
- PMID 26679998
- Cyclophilin B enhances HIV-1 infection.
- DeBoer J1, Madson CJ1, Belshan M2.
- Virology.Virology.2016 Feb;489:282-91. doi: 10.1016/j.virol.2015.12.015. Epub 2016 Jan 14.
- Cyclophilin B (CypB) is a member of the immunophilin family and intracellular chaperone. It predominantly localizes to the ER, but also contains a nuclear localization signal and is secreted from cells. CypB has been shown to interact with the Gag protein of human immunodeficiency type 1 (HIV-1). Se
- PMID 26774171
Japanese Journal
- ポリグルタミン病モデルにおけるimmunophilin高発現の効果
- Expression of a Constitutively Active Calcineurin Encoded by an Intron-Retaining mRNA in Follicular Keratinocytes
- Fujimura Atsushi,Michiue Hiroyuki,Nishiki Tei-ichi,Ohmori Iori,Wei Fanyan,Matsui Hideki,Tomizawa Kazuhito
- PLoS ONE 6(3), 2011-05-14
- … Immunosuppressive immunophilin ligands such as cyclosporin A (CsA) and FK506 are known as potent hair growth modulatory agents in rodents and humans that induce active hair growth and inhibit hair follicle regression. …
- NAID 120005232485
- Cyclophilin A : Promising New Target in Cardiovascular Therapy
- , ,
- Circulation journal : official journal of the Japanese Circulation Society 74(11), 2249-2256, 2010-10-25
- … CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. …
- NAID 10026972151
Related Links
- In molecular biology, immunophilins are endogenous cytosolic peptidyl-prolyl isomerases that interconvert between the cis and trans positions. Immunophilins are targeted by immunosuppressive drugs such as rapamycin, ciclosporin, and ...
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