English Journal

Changes in biomarkers during a six-month oral immunotherapy intervention for cow's milk allergy.

Salmivesi S1, Paassilta M2, Huhtala H3, Nieminen R4, Moilanen E4, Korppi M5,6.
Acta paediatrica (Oslo, Norway : 1992).Acta Paediatr.2016 Nov;105(11):1349-1354. doi: 10.1111/apa.13550.
AIM: Oral immunotherapy (OIT) is a promising but still experimental method to treat children with cow's milk (CM) allergy (CMA). We evaluated changes in allergic, immunological and inflammatory parameters, which happened during the six-month OIT for CMA.METHODS: We treated 28 school-aged children wi
PMID 27537244

Amatullah H1,2, Shan Y3, Beauchamp BL4, Gali PL5, Gupta S6, Maron-Gutierrez T7, Speck ER8, Fox-Robichaud AE9, Tsang JL10, Mei SH11, Mak TW12, Rocco PR13, Semple JW14, Zhang H15, Hu P16, Marshall JC17, Stewart DJ18, Harper ME19, Liaw PC20, Liles WC21, Dos Santos CC22; Canadian Critical Care Translational Biology Group (CCCTBG).
American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2016 Oct 13. [Epub ahead of print]
RATIONALE & OBJECTIVES: Effective and rapid bacterial clearance is a fundamental determinant of outcome(s) in sepsis. DJ-1 is a well-established reactive oxygen species (ROS) scavenger. As cellular ROS status is pivotal to inflammation and bacterial killing, we determined the role of DJ-1 in bac
PMID 27735193

Anti-inflammatory Effects of Nortrachelogenin in Murine J774 Macrophages and in Carrageenan-Induced Paw Edema Model in the Mouse.

Laavola M1, Leppänen T1, Eräsalo H1, Hämäläinen M1, Nieminen R1, Moilanen E1.
Planta medica.Planta Med.2016 Oct 13. [Epub ahead of print]
Nortrachelogenin is a pharmacologically active lignan found in knot extracts of Pinus sylvestris. In previous studies, some lignans have been shown to have anti-inflammatory properties, which made nortrachelogenin an interesting candidate for our study. In inflammation, bacterial products and cytoki
PMID 27737478

Japanese Journal

Efficient generation of highly immunocompetent dendritic cells from peripheral blood of patients with hepatitis C virus-related hepatocellular carcinoma

Kitahara Masaaki,Mizukoshi Eishiro,Nakamoto Yasunari,Mukaida Naofumi,Matsushima Kouji,Kaneko Shuichi
International Immunopharmacology
Background & aims Immunotherapy using dendritic cells (DCs) is a promising cancer therapy. The success of this therapy depends on the function of induced DCs. However, there has been no consensus …
NAID 120005463368

Quercetin inhibits transcriptional up-regulation of histamine H-1 receptor via suppressing protein kinase C-delta/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells

Hattori M,Mizuguchi H,Baba Y,Ono S,Nakano T,Zhang Q,Sasaki Y,Kobayashi M,Kitamura Y,Takeda N,Fukui H
INTERNATIONAL IMMUNOPHARMACOLOGY
NAID 120005609341

Altered gene expression profiles associated with enhanced skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate in streptozotocin-diabetic mice