WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/03 06:58:08」(JST)

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An immune receptor (or immunologic receptor) is a receptor, usually on a cell membrane, which binds to a substance (for example, a cytokine) and causes a response in the immune system.

Types

The main receptors in the immune system are pattern recognition receptors (PRRs), Toll-like receptors (TLRs), killer activated and killer inhibitor receptors (KARs and KIRs), complement receptors, Fc receptors, B cell receptors and T cell receptors.^[1]

Comparison
Receptor	Bind to ^[1]	Function^[1]
pattern recognition receptors (PRRs) (e.g. TLRs, NLRs)	pathogen-associated molecular patterns (PAMP)	Mediate cytokine production --> inflammation --> destroying pathogen
killer activated and killer inhibitor receptors (KARs and KIRs)		Avails NK cells to identify abnormal host cells (KAR) or inhibit inappropriate host cell destruction (KIR)
complement receptors	complement proteins on e.g. microbes	Allow phagocytic and B cells to recognize microbes and immune complexes
Fc receptors	epitope-antibody complexes	Stimulate phagocytosis
B cell receptors	epitopes	B cell differentiation into plasma cells and proliferation
T cell receptors	linear epitopes bound to MHC	Activate T cells
Cytokine receptors	cytokines	regulation and co-ordination of immune responses

References

^ ^a ^b ^c Lippincott's Illustrated Reviews: Immunology. Paperback: 384 pages. Publisher: Lippincott Williams & Wilkins; (July 1, 2007). Language: English. ISBN 0-7817-9543-5. ISBN 978-0-7817-9543-2. Page 20

External links

immunologic receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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English Journal

Abatacept Inhibition of T Cell Priming in Mice by Induction of a Unique Transcriptional Profile That Reduces Their Ability to Activate Antigen-Presenting Cells.

Patakas A1, Ji RR2, Weir W1, Connolly SE2, Benson RA1, Nadler SG2, Brewer JM1, McInnes IB1, Garside P1.
Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2016 Mar;68(3):627-38. doi: 10.1002/art.39470.
OBJECTIVE: To determine at the phenotypic, functional, and transcriptional levels whether abatacept, a CTLA-4Ig molecule that binds with high affinity to CD80/86 on antigen-presenting cells (APCs) and is used to treat rheumatoid arthritis, induces a state of immunologic tolerance in T cells and dend
PMID 26473409

Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions.

James LK1, Till SJ2.
Current allergy and asthma reports.Curr Allergy Asthma Rep.2016 Mar;16(3):23. doi: 10.1007/s11882-016-0600-2.
IgG4 is the least abundant IgG subclass in human serum, representing less than 5 % of all IgG. Increases in IgG4 occur following chronic exposure to antigen and are generally associated with states of immune tolerance. In line with this, IgG4 is regarded as an anti-inflammatory antibody with a limi
PMID 26892721

Myf5 and Myogenin in the development of thymic myoid cells - Implications for a murine in vivo model of myasthenia gravis.

Hu B1, Simon-Keller K1, Küffer S2, Ströbel P2, Braun T3, Marx A1, Porubsky S4.
Experimental neurology.Exp Neurol.2016 Mar;277:76-85. doi: 10.1016/j.expneurol.2015.12.010. Epub 2015 Dec 18.
Myasthenia gravis (MG) is caused by autoantibodies against the neuromuscular junction of striated muscle. Most MG patients have autoreactive T- and B-cells directed to the acetylcholine receptor (AChR). To achieve immunologic tolerance, developing thymocytes are normally eliminated after recognition
PMID 26708556