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1. 上部消化管の上皮下病変評価のための超音波内視鏡検査 endoscopic ultrasound for the characterization of subepithelial lesions of the upper gastrointestinal tract
2. 腎移植におけるBKウイルス（ポリオーマウイルス）腎症の臨床症状および診断 clinical manifestations and diagnosis of bk virus induced polyomavirus induced nephropathy in kidney transplantation
3. 線状苔癬 lichen striatus
4. 潜在性原発乳癌の腋窩リンパ節転移 axillary node metastases with occult primary breast cancer
5. 過敏性腸症候群の病態生理 pathophysiology of irritable bowel syndrome

English Journal

Suck-ligate-unroof-biopsy by using a detachable 20-mm loop for the diagnosis and therapy of small subepithelial tumors (with video).

Binmoeller KF, Shah JN, Bhat YM, Kane SD.Author information Paul May & Frank Stein Interventional Endoscopy Center, California Pacific Medical Center, San Francisco, California, USA.AbstractBACKGROUND: The diagnosis and therapy of subepithelial tumors (SETs) can be challenging.
Gastrointestinal endoscopy.Gastrointest Endosc.2014 May;79(5):750-5. doi: 10.1016/j.gie.2013.09.028. Epub 2013 Nov 12.
BACKGROUND: The diagnosis and therapy of subepithelial tumors (SETs) can be challenging.OBJECTIVE: Proof-of-concept evaluation of the suck-ligate-unroof-biopsy (SLUB) technique for small (<2 cm), non-pedunculated SETs.DESIGN: Pilot feasibility study.SETTING: Tertiary-care referral center.PATIENTS
PMID 24238309

Growth and differentiation factor-5 (GDF-5) in the human intervertebral annulus cells and its modulation by IL-1ß and TNF-α in vitro.

Gruber HE1, Hoelscher GL2, Ingram JA2, Bethea S2, Hanley EN Jr2.Author information 1Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC, USA. Electronic address: helen.gruber@carolinashealthcare.org.2Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC, USA.AbstractGrowth and differentiation factor-5 (GDF-5) is a member of the TGF-ß superfamily which regulates cell division and differentiation. GDF-5 attracted high interest because of its role in skeletal development, especially in cartilaginous sites. Little is known, however, about the role of GFD-5 in disc cell biology. The present work demonstrated the immunohistologic presence of GDF-5 in human outer and inner annulus tissue. Microarray analysis of annulus cells showed significant upregulation of GDF-5 expression in herniated vs. non-herniated lumbar discs (2.14-fold change, p=0.021). In vitro three-dimensional culture studies challenged human annulus cells with IL-1ß and TNF-α, two proinflammatory cytokines known to be elevated in the human degenerating disc. Exposure resulted in significant downregulation of GDF-5 during both TNF-α exposure (5.83-fold change, p=0.044) and IL-1ß exposure (3.38-fold change, p=0.015). In vitro findings suggest that the degenerating disc milieu, with high proinflammatory cytokine levels, may limit expression of GDF-5, resulting in limited regenerative capacity of the intact disc.
Experimental and molecular pathology.Exp Mol Pathol.2014 Apr;96(2):225-9. doi: 10.1016/j.yexmp.2014.02.005. Epub 2014 Feb 25.
Growth and differentiation factor-5 (GDF-5) is a member of the TGF-ß superfamily which regulates cell division and differentiation. GDF-5 attracted high interest because of its role in skeletal development, especially in cartilaginous sites. Little is known, however, about the role of GFD-5 in disc
PMID 24582800

VHL-deficient vasculogenesis in hemangioblastoma.

Gläsker S1, Smith J2, Raffeld M3, Li J4, Oldfield EH5, Vortmeyer AO6.Author information 1Department of Neurosurgery, Freiburg University Medical Center, Germany.2Department of Neurology, Mayo Clinic, Rochester, MN, USA.3Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA.4Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.5Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD, USA.6Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: alexander.vortmeyer@yale.edu.AbstractHemangioblasts are capable of differentiation into vascular structures and blood. Patients with von Hippel-Lindau (VHL) disease develop hemangioblastomas which are composed of VHL-deficient tumor cells with protracted hemangioblastic differentiation potential. In a subset of these tumors, hemangioblastic differentiation is characterized by different stages of red blood cell formation. It has remained controversial, however, whether VHL-deficient hemangioblastic cells are similarly capable of differentiating into vascular cells and functioning vascular structures in vivo. By histologic, immunohistologic and microdissection-based genetic analysis of 60 VHL disease-associated hemangioblastomas, we re-examined the controversial question whether VHL-deficient neoplastic hemangioblastic cells are capable of vascular differentiation (vasculogenesis). In most tumors (n=47), there was no evidence of either vasculogenesis or hematopoiesis; tumor cells were either scattered between reactive angiogenetic vascular structures or arranged in solid clusters. A subset of tumors (n=13), however, revealed vaculogenetic structures that were composed of cuboidal or flat cells and frequently contained red blood cell precursors or mature red blood cells. Microdissection-based deletion analysis of epithelial cells confirmed them to be VHL-deficient tumor cells. Immunohistochemistry for CD31 was consistently negative in these structures, and no evidence could be obtained for connectivity with reactive vasculature. We demonstrate that hemangioblastic differentiation capacity of VHL-deficient hemangioblastic cells includes not only erythropoiesis, but also differentiation into primitive vasculogenetic structures. Tumor cells, however, do not appear to have the potential of terminal differentiation into mature and functional vascular structures.
Experimental and molecular pathology.Exp Mol Pathol.2014 Apr;96(2):162-7. doi: 10.1016/j.yexmp.2013.12.011. Epub 2014 Jan 4.
Hemangioblasts are capable of differentiation into vascular structures and blood. Patients with von Hippel-Lindau (VHL) disease develop hemangioblastomas which are composed of VHL-deficient tumor cells with protracted hemangioblastic differentiation potential. In a subset of these tumors, hemangiobl
PMID 24394472

Japanese Journal

Sheep colon acellular matrix : Immunohistologic, biomechanical, scanning electron microscopic evaluation and collagen quantification

Kajbafzadeh Abdol-Mohammad,Masoumi Ahmad,Hosseini Mohammad [他]
Journal of bioscience and bioengineering 117(2), 236-241, 2014-02
NAID 40019991288

Sheep colon acellular matrix : Immunohistologic, biomechanical, scanning electron microscopic evaluation and collagen quantification(CELL AND TISSUE ENGINEERING)

Kajbafzadeh Abdol-Mohammad,Masoumi Ahmad,Hosseini Mohammad,Borjian Mohammad Amin,Akbarzadeh Aram,Mohseni Mohammad Javad
Journal of bioscience and bioengineering 117(2), 236-241, 2014-02
Colon decellularization provides three-dimensional biologic scaffold without any cell elements with preservation of extracellular matrix in order to enable autologous cell seeding for tissue augmentat …
NAID 110009804079

横行結腸間膜に発生した平滑筋腫瘍の1例

田中宏明,池田拓人,小倉康裕,上田祐滋,島尾義也
日本臨床外科学会雑誌 74(9), 2541-2545, 2013
55歳の女性．検診にて腹腔内腫瘤を指摘され当院へ紹介された．触診で左上腹部に手拳大で可動性不良の硬い腫瘤を触れた．腹部超音波では境界明瞭，内部エコー不均一な充実性腫瘤として認め，CT所見では80×70×45mm大の境界明瞭，造影効果の乏しい腫瘍であった．原発不明の腹腔内腫瘍との術前診断のもとに，腹腔鏡下に切除術を施行した．腫瘍は横行結腸間膜と茎状に連なる形で存在し，周囲組織への浸潤は認めなかった． …
NAID 130004518854