WordNet
- a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/28 03:54:33」(JST)
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Some antibodies form complexes that bind to multiple antigen molecules.
An isotype refers to any related proteins from a particular gene family. In immunology, the "immunoglobulin isotype" refers to the phenotypic variations in the constant regions of the heavy and light chains. In humans, there are five heavy chain isotypes and two light chain isotypes:
- heavy chain
- α - IgA 1, 2
- δ - IgD
- γ - IgG 1, 2, 3, 4
- ε - IgE
- μ - IgM
- light chain
Immunoglobulin class switching can be used to change the class of the heavy chain, but not of the light chain.
Isotypes are distinct forms of light or heavy chains which are present in all members of a species, encoded at distinct genetic loci. Kappa and lambda are isotypes of light chains. Delta (δ), gamma:1 (γ1), etc. are isotypes of heavy chains. All isotypes can be readily found in normal sera.
See also
External links
- Immunoglobulin Isotypes at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview at University of South Carolina School of Medicine
- Overview at Southern Illinois University Carbondale
Immunology: lymphocytic adaptive immune system and complement
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Lymphoid |
Antigens |
- Antigen presentation/Professional APCs: Dendritic cell
- Macrophage
- B cell
- Immunogen
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Antibodies |
- Antibody
- Monoclonal antibodies
- Polyclonal antibodies
- Autoantibody
- Microantibody
- Polyclonal B cell response
- Allotype
- Isotype
- Idiotype
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Immunity vs.
tolerance |
- action: Immunity
- Autoimmunity
- Alloimmunity
- Allergy
- Hypersensitivity
- Inflammation
- Cross-reactivity
- inaction: Tolerance
- Central
- Peripheral
- Clonal anergy
- Clonal deletion
- Tolerance in pregnancy
- Immunodeficiency
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Immunogenetics |
- Affinity maturation (Somatic hypermutation
- Clonal selection)
- V(D)J recombination
- Junctional diversity
- Immunoglobulin class switching
- MHC/HLA
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Lymphocytes |
- Cellular (T cell)
- Humoral (B cell)
- NK cell
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Substances |
- Cytokines
- Opsonin
- Cytolysin
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Index of the immune system
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Description |
- Physiology
- cells
- autoantigens
- autoantibodies
- complement
- surface antigens
- IG receptors
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Disease |
- Allergies
- Immunodeficiency
- Immunoproliferative immunoglobulin disorders
- Hypersensitivity and autoimmune disorders
- Neoplasms and cancer
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Treatment |
- Procedures
- Drugs
- antihistamines
- immunostimulants
- immunosuppressants
- monoclonal antibodies
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Index of the lymphatic system
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Description |
- Anatomy
- Physiology
- Development
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Disease |
- Vessels
- Organs
- congenital
- neoplasms and cancer
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Treatment |
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UpToDate Contents
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English Journal
- Recent findings on the structure and function of teleost IgT.
- Zhang YA, Salinas I, Oriol Sunyer J.SourceDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- Fish & shellfish immunology.Fish Shellfish Immunol.2011 Nov;31(5):627-634. Epub 2011 Apr 3.
- As key effector molecules of jawed vertebrate's adaptive immune system, immunoglobulins are produced by B lymphocytes, either as a secretory form (antibody) or as a membrane form (B cell receptor). Until recently, teleost fish B cells were thought to express only two classes of immunoglobulins, IgM
- PMID 21466854
- Sub-chronic effect of perfluorooctanesulfonate (PFOS) on the balance of type 1 and type 2 cytokine in adult C57BL6 mice.
- Dong GH, Liu MM, Wang D, Zheng L, Liang ZF, Jin YH.SourceSchool of Public Health, China Medical University, North 2nd Road, 110001, Heping Districts, Shenyang, People's Republic of China, ghdong@mail.cmu.edu.cn.
- Archives of toxicology.Arch Toxicol.2011 Oct;85(10):1235-44. Epub 2011 Feb 16.
- As a ubiquitous and highly persistent environmental contaminant, the clear mechanisms to explain any perfluorooctanesulfonate (PFOS)-induced immunotoxicity are still unknown. This study here sought to examine the ability of PFOS to potentially perturb T-helper (T(H))-1 and T(H)-2 cell cytokine secre
- PMID 21327619
Japanese Journal
- 喉頭癌発症におけるヒト乳頭腫ウイルス(HPV)の発現と喉頭局所免疫の関与
- 千年 俊一,坂崎 友,深堀 光緒子,小野 剛治,前田 明輝,梅野 博仁,中島 格
- 喉頭 = The Larynx Japan 22(2), 83-87, 2010-12-01
- … Cytological samples for the detection of HPV and laryngeal secretions for the collection of immunoglobulin (Ig) were obtained from 31 patients with laryngeal diseases during microscopic surgery of the larynx. … A comparison of laryngeal cancer and benign laryngeal diseases revealed that patients with laryngeal cancer had a higher concentration in each Ig isotype in laryngeal secretions than patients with benign laryngeal diseases. …
- NAID 10027844398
- Waldenstrom's macroglobulinemia in a 10-year stable IgG monoclonal gammopathy of undetermined significance
- Iwanaga Masako,Yoshida Yoshiharu,Tagawa Masuko,Sekine Ichiro,Kamihira Shimeru,Tomonaga Masao
- Leukemia Research 33(1), 193-195, 2009-01-01
- NAID 120000916859
Related Links
- An isotype usually refers to any related proteins/genes from a particular gene family. In immunology, the "immunoglobulin isotype" refers to the genetic variations or differences in the constant regions of the heavy and light chains In humans, ...
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