English Journal

Down-regulation of carboxylesterases 1 and 2 plays an important role in prodrug metabolism in immunological liver injury rats.

Zhang C, Xu Y, Gao P, Lu J, Li X, Liu D.
International immunopharmacology. 2015 Feb;24(2)153-158.
Liver plays a central role in xenobiotics metabolism, thus affecting the in vivo disposition and therapeutic effects of drugs. Carboxylesterases (CESs), with the main isoforms CES1 and CES2, are important in the metabolism of ester-type prodrugs. However, influences of immunological liver injury on
PMID 25499727

Effects of imidapril treatment on aquaporin-2 expression in the kidneys and excretion in the urine of hypertensive rats.

Zhao W, Xu AG, Wu J, Guo J, Xu QF, Li DD, Zhao YM.
Experimental and therapeutic medicine. 2013 May;5(5)1327-1331.
Renal aquaporin-2 (AQP2) is critical for maintaining water balance and is associated with hypertension. Anti-hypertensive drugs, including imidapril, improve kidney function; however, it remains unclear whether these effects are mediated through the regulation of AQP2. In this study, the effects of
PMID 23737873

Significance of matrix metalloproteinase-9 inhibition by imidapril for prevention of abdominal aortic aneurysms in angiotensin II type 1 receptor-knockout mice.

Takai S, Jin D, Yamamoto D, Li ZL, Otsuki Y, Miyazaki M.
Journal of pharmacological sciences. 2013 ;123(2)185-94.
To clarify the matrix metalloproteinase (MMP)-9 inhibitory effect of an angiotensin-converting enzyme (ACE) inhibitor in vivo, we evaluated the effect of an ACE inhibitor against elastase-induced abdominal aortic aneurysm (AAA) progression in mice. Molecular models showed that imidapril bound direct
PMID 24096831

Japanese Journal

Imidaprilat suppresses nonylphenol and 1-methyl-4-phenylpyridinium ion (MPP^+)-induced hydroxyl radical generation in rat striatum

OBATA Toshio
Neuroscience research : the official journal of the Japan Neuroscience Society 54(3), 192-196, 2006-03-01
NAID 10017323726

Imidaprilat Potentiates Endothelium Dependent Hyperpolarizationin Rabbit Resistant Mesenteric Artery

Ohhashi Masuo,Sugiyama Masaya,Dohi Yasuaki,Ueda Ryuzo,Itoh Takeo
Circulation journal : official journal of the Japanese Circulation Society 67(Supplement_I), 412, 2003-03-01
NAID 110002710082

ブラジキニンの代謝酵素に及ぼすエナラプリラートおよびイミダプリラートの影響

坂本公一,杉本孝一,須藤俊明,藤村昭夫
臨床薬理 31(1), 183-184, 2000-01-01
NAID 10011537467

Related Links

Imidaprilat | C18H23N3O6 - PubChem - The PubChem Project

Imidaprilat is a member of the class of imidazolidines that is imidapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of imidapril used to treat hypertension. It has a role ...