idiotypes

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/02 19:00:27」(JST)

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An idiotope is the unique set of antigenic determinants (epitopes) of the variable portion of an antibody. In some cases it can be the actual antigen-binding site, and in some cases it may comprise variable region sequences outside of the antigen-binding site on the antibody itself. Thus each antibody would have multiple idiotopes; and the set of these individual idiotopes is termed the idiotype of the antibody.

Idiotopes contrast with allotopes, which are non-varying structures on the Fc receptor.

If a separate antibody is produced that has specific binding capabilities to an idiotope of the previously described antibody, it is said to be an "anti-idiotypic antibody". If such is the case, the anti-idiotypic antibodies will be able to bind to the B lymphocyte receptor for the original antigen and inhibit the immune response to that antigen.

This type of regulation was proposed by Niels Jerne in 1974. He termed it the "Network Hypothesis". This type of B lymphocyte regulation may be partially responsible for preventing an immune response from getting out of control, which would elicit damage to host tissue or even cause an autoimmune diseased state.

Because of the resemblance of anti-idiotypic antibodies to the original antigen, vaccine studies have been performed. These types of vaccines are called "idiotypic vaccines". None are produced commercially to date.

References

UpToDate Contents

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• 1. 免疫グロブリンの構造 structure of immunoglobulins
• 2. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation
• 3. 免疫グロブリン静脈内投与（IVIG）療法の概要 overview of intravenous immune globulin ivig therapy
• 4. 全身性エリテマトーデスの疫学および病因 epidemiology and pathogenesis of systemic lupus erythematosus

English Journal

• Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study.

• McCann KJ1, Godeseth R, Chudley L, Mander A, Di Genova G, Lloyd-Evans P, Kerr JP, Malykh VB, Jenner MW, Orchard KH, Stevenson FK, Ottensmeier CH.
• Cancer immunology, immunotherapy : CII.Cancer Immunol Immunother.2015 Aug;64(8):1021-32. doi: 10.1007/s00262-015-1703-7. Epub 2015 May 16.
• We report on the safety and immunogenicity of idiotypic DNA vaccination in a phase I, non-randomised, open-label study in patients with multiple myeloma. The study used DNA fusion gene vaccines encoding patient-specific single chain variable fragment, or idiotype (Id), linked to fragment C (FrC) of
• PMID 25982371

• Antibodies: At The Nexus of Antigens and Cancer Vaccines.

• Steplewski Z1, Thurin M2, Kieber-Emmons T3.
• The Journal of infectious diseases.J Infect Dis.2015 Jul 15;212 Suppl 1:S59-66. doi: 10.1093/infdis/jiu638.
• This review describes the development of monoclonal antibodies and the inception of their use in cancer therapy, their impact on defining cancer biomarkers, and their structural utility in new cancer vaccine development. © The Author 2015. Published by Oxford University Press on behalf of the Infec
• PMID 26116735

• Rheumatoid factor in idiotypic regulation of autoimmunity.

• Beduleva L1, Menshikov I1, Stolyarova E1, Fomina K1, Lobanova O1, Ivanov P1, Terentiev A1.
• International journal of rheumatic diseases.Int J Rheum Dis.2015 May;18(4):408-20. doi: 10.1111/1756-185X.12335. Epub 2014 Mar 26.
• AIM: Rheumatoid factor (RF) is known to be heterogeneous, and RFs detected by various methods exhibit different characteristics. In addition to interacting with the Fc region of immunoglobulin G (IgG), certain RFs are able to recognize idiotypes of antibodies. Given the important role of idiotypic i
• PMID 24666434

Japanese Journal

• 基調講演 理論と実務の架橋--その理念と実際 (臨床法学教育ワークショップ 司法改革時代の英国および日本の法専門職教育--法学研究者と法実務者の協働)

• 紙谷 雅子
• 臨床法学セミナー (7), 22-33, 2009-09
• NAID 40016941412

Related Links

• Idiotype - Wikipedia, the free encyclopedia

In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of ...

• Idiotopes - Wikipedia, the free encyclopedia

If a separate antibody is produced that has specific binding capabilities to an idiotope of the previously described antibody, it is said to be an "anti-idiotypic antibody". If such is the case, the anti-idiotypic antibodies will be able to bind to the B ...

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英

idiotypes

関

アイソタイプ、アロタイプ

• differences due to particular rearranged V_H and V_L genes are callved idiotypes.(IMM.748)

• [[*特定のB細胞クローンによってつくられる抗体，すなわち特定の抗原特異性を示す抗体の抗原性によって決まる免疫グロブリンのタイプ。免疫グロブリンは抗原特異性の異なる多様なレパトアを形成しているが，免疫グロブリンの抗原結合部位にはそれぞれの抗体分子に特有な抗原構造が存在し，この構造（イディオトープ）に対しても抗体がつくられうる。このイディオトープに対する抗体によって決定される抗体のタイプをイディオタイプと呼ぶ。]]