WordNet

(of diseases) arising from an unknown cause; "idiopathic epilepsy"
pertaining to an upright standing posture; "orthostatic hypotension"
abnormally low blood pressure

PrepTutorEJDIC

特発性疾患の(病気の原因があいまいな,また不明な場合)
低血圧[症]

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/07/30 06:25:35」(JST)

wiki en

Pure autonomic failure, also known as Bradbury-Eggleston syndrome or idiopathic orthostatic hypotension, is a form of dysautonomia that first occurs in middle age or later in life; men are affected more often than women. It is one of three diseases classified as primary autonomic failure.

Symptoms

A degenerative disease of the autonomic nervous system, symptoms include dizziness and fainting (caused by orthostatic hypotension), visual disturbances and neck pain. Chest pain, fatigue and sexual dysfunction are less common symptoms that may also occur. Symptoms are worse when standing; sometimes one may relieve symptoms by lying down.

Pathology

The pathology of pure autonomic failure is not yet completely understood. However, a loss of cells in the intermediolateral column of the spinal cord has been documented, as has a loss of catecholamine uptake and catecholamine fluorescence in sympathetic postganglionic neurons. In general, levels of catecholamines in these patients are very low while lying down, and do not increase much upon standing.

Treatment

Pharmacological methods of treatment include fludrocortisone, midodrine, somatostatin, erythropoietin, and other vasopressor agents. However, often a patient with pure autonomic failure can mitigate his or her symptoms with far less costly means. Compressing the legs and lower body, through crossing the legs, squatting, or the use of compression stockings can help. Also, ingesting more water than usual can increase blood pressure and relieve some symptoms.

Eponym

It is named for Samuel Bradbury and Cary Eggleston.^[1]^[2]

References

^ synd/2102 at Who Named It?
^ S. Bradbury, C. Eggleston. Postural hypotension: A report of three cases. American Heart Journal, St. Louis, 1925, 1: 73-86.

Vanderbilt Autonomic Dysfunction Center

External links

Dysautonomia International

National Dysautonomia Research Foundation (NDRF)

Dysautonomia Support Network

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 起立性低血圧のメカニズム、原因、および評価 mechanisms causes and evaluation of orthostatic hypotension
2. 特発性過眠症 idiopathic hypersomnia
3. 多系統萎縮症：臨床的特徴および診断 multiple system atrophy clinical features and diagnosis
4. パーキンソン病の診断 diagnosis of parkinson disease
5. 小児および思春期における失神の原因 causes of syncope in children and adolescents

English Journal

Middle Cerebral Artery Occlusion Presenting as Upper Limb Monochorea.

Noda K1, Nakajima S2, Sasaki F2, Ito Y3, Kawajiri S4, Tomizawa Y4, Hattori N5, Yamamoto T3, Okuma Y4.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.J Stroke Cerebrovasc Dis.2015 Oct;24(10):e291-3. doi: 10.1016/j.jstrokecerebrovasdis.2015.06.009. Epub 2015 Aug 17.
BACKGROUND: Hemichorea is usually caused by a structural lesion in the contralateral basal ganglia or subthalamic nuclei or it develops as a form of a neurologic complication including hyperglycemia. We report a rare case of a patient who developed choreic movement in the right upper extremity assoc
PMID 26294216

[Pure autonomic failure and acetylcholine: historical and current aspects].

Asahina M1.
Brain and nerve = Shinkei kenkyū no shinpo.Brain Nerve.2014 May;66(5):539-50.
The discovery of acetylcholine was closely related to research on the autonomic nervous system. At the onset of the twentieth century, John Newport Langley (1852-1925), a patriarch of modern autonomic research, classified the autonomic nervous system into the sympathetic, parasympathetic, and entera
PMID 24807370

[General anesthesia in a patient with idiopathic orthostatic hypotension].

Ionescu I1, Blanc-Groebe I, Goetz AE, Kubitz JC.
Der Anaesthesist.Anaesthesist.2010 Feb;59(2):140-3. doi: 10.1007/s00101-010-1675-0.
Idiopathic orthostatic hypotension (formerly known as Shy-Drager syndrome) is a multiple system atrophy, which is characterized by autonomic dysregulation. Providing perioperative hemodynamic stability during narcosis is therefore a particular challenge. The effects of general anesthesia on systemic
PMID 20127057