WordNet

surgical removal of the pituitary gland
remove the pituitary glands (同)hypophysectomise

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/28 06:18:18」(JST)

wiki en

Hypophysectomy is the surgical removal of the hypophysis (pituitary gland). It is most commonly performed to treat tumors, especially craniopharyngioma tumors.^[1] Sometimes it is used to treat Cushing's syndrome due to pituitary adenoma.^[2] It is also applied in neurosciences (in experiments with lab animals) to understand the functioning of hypophysis.

Medications that are given as hormone replacement therapy following a complete hypophysectomy (removal of the pituitary gland) are often glucocorticoids. Secondary Addison's and hyperlipidemia can occur. Thyroid hormone is useful in controlling cholesterol metabolism that has been affected by pituitary deletion.^[3]

Complications

Hypophysectomy performed at any age causes atrophy of the thyroid and adrenal glands as well as asthenia and cachexia. When the procedure is performed before sexual maturity, the reproductive tract remains undeveloped and non-functional. There is also a general lack of growth. If performed after sexual maturity, there will be a loss of reproductive function along with atrophy of gonads and accessory reproductive structures. There is a risk of Cerebral Spinal fluid leak due to penetration of the basal skull,risk of Increase cerebral spinal fluid pressure that may lead to Central Nervous system changes. Increased risk of hemorrhage and infection secondary to the surgical procedure. Post surgery patients may have a severely altered self-image that may lead to an increased the risk of suicide.^[4]

References

^ Jaffe, CA (2006). "Clinically non-functioning pituitary adenoma.". Pituitary 9 (4): 317–21. doi:10.1007/s11102-006-0412-9. PMID 17082898.
^ Buchfelder, M; Schlaffer, S (2010). "Pituitary surgery for Cushing's disease.". Neuroendocrinology. 92 Suppl 1: 102–6. doi:10.1159/000314223. PMID 20829628.
^ "Dramatically Increased Intestinal Absorption of Cholesterol Following Hypophysectomy Is Normalized by Thyroid Hormone" (PDF).
^ Swearingers. Manuel of medical surgical nursing: A care planning Resource. 7th Edition

External links

Encyclopedia of Surgery

This oncology article is a stub. You can help Wikipedia by expanding it.

This surgery article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. クッシング病の一次治療：経蝶形骨洞手術および下垂体照射 primary therapy of cushings disease transsphenoidal surgery and pituitary irradiation
2. クッシング症候群の治療の概要 overview of the treatment of cushings syndrome
3. 下垂体機能低下症の原因 causes of hypopituitarism
4. 中枢性尿崩症の臨床症状および原因 clinical manifestations and causes of central diabetes insipidus
5. 糖尿病性網膜症：病因 diabetic retinopathy pathogenesis

English Journal

Endoscopic radical hypophysectomy: how I do it.

Cárdenas Ruiz-Valdepeñas E1, Kaen A2, Perez Prat G2.
Acta neurochirurgica.Acta Neurochir (Wien).2016 Sep 15. [Epub ahead of print]
BACKGROUND: Total hypophysectomy it is a classical procedure that currently has many indications especially in patients with Cushing syndrome without good endocrine control. Expanded endonasal endoscopic techniques grant us an alternative standpoint to the classic trans-sphenoidal microscopic approa
PMID 27638642

Pediatric pituitary resection: characterizing surgical approaches and complications.

Hanba C1, Svider PF2, Shkoukani MA1, Sheyn A3,4, Jacob JT5,6, Eloy JA7,8,9,10, Folbe AJ1,11.
International forum of allergy & rhinology.Int Forum Allergy Rhinol.2016 Sep 14. doi: 10.1002/alr.21840. [Epub ahead of print]
BACKGROUND: Although there has been extensive study evaluating adult pituitary surgery, there has been scant analysis among children. Our objective was to evaluate a population-based resource to characterize nationwide trends in surgical approach, hospital stay, and complications among children unde
PMID 27626904

Regulation of gill claudin paralogs by salinity, cortisol and prolactin in Mozambique tilapia (Oreochromis mossambicus).

Tipsmark CK1, Breves JP2, Rabeneck DB3, Trubitt RT3, Lerner DT4, Grau EG5.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2016 Sep;199:78-86. doi: 10.1016/j.cbpa.2016.05.014. Epub 2016 May 19.
In euryhaline teleosts, reorganization of gill tight junctions during salinity acclimation involves dynamic expression of specific claudin (Cldn) paralogs. We identified four transcripts encoding Cldn tight junction proteins in the tilapia gill transcriptome: cldn10c, cldn10e, cldn28a and cldn30. A
PMID 27210417