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English Journal

AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport.

Samal K, Zhao P, Kendzicky A, Yco LP, McClung H, Gerner E, Burns M, Bachmann AS, Sholler G.SourceCenter for Translational Medicine, Van Andel Research Institute, Grand Rapids, Michigan.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Sep 15;133(6):1323-33. doi: 10.1002/ijc.28139. Epub 2013 May 30.
Neuroblastoma (NB) is associated with MYCN oncogene amplification occurring in approximately 30% of NBs and is associated with poor prognosis. MYCN is linked to a number of genes including ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. ODC expression is elevated i
PMID 23457004

A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation.

Paulus WJ, Tschöpe C.SourceDepartment of Physiology, Institute for Cardiovascular Research VU, VU University Medical Center Amsterdam, Amsterdam, the Netherlands. Electronic address: wj.paulus@vumc.nl.
Journal of the American College of Cardiology.J Am Coll Cardiol.2013 Jul 23;62(4):263-71. doi: 10.1016/j.jacc.2013.02.092. Epub 2013 May 15.
Over the past decade, myocardial structure, cardiomyocyte function, and intramyocardial signaling were shown to be specifically altered in heart failure with preserved ejection fraction (HFPEF). A new paradigm for HFPEF development is therefore proposed, which identifies a systemic proinflammatory s
PMID 23684677

Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.

Hampl V, Martin C, Aigner A, Hoebel S, Singer S, Frank N, Sarikas A, Ebert O, Prywes R, Gudermann T, Muehlich S.SourceWalther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany.
EMBO molecular medicine.EMBO Mol Med.2013 Jul 12. doi: 10.1002/emmm.201202406. [Epub ahead of print]
Megakaryoblastic leukaemia 1 and 2 (MKL1/2) are coactivators of the transcription factor serum response factor (SRF). Here, we provide evidence that depletion of MKL1 and 2 abolishes hepatocellular carcinoma (HCC) xenograft growth. Loss of the tumour suppressor deleted in liver cancer 1 (DLC1) and t
PMID 23853104

Ethionine-Induced ATP Depletion Represses mTOR Signaling in the Absence of Increases in AMP-Activated Protein Kinase Activity in the Rat Liver

Yoshizawa Fumiaki,Mochizuki Shinji,Doi Masako [他],YAMAOKA Ippei,SUGAHARA Kunio
Bioscience, biotechnology, and biochemistry 73(9), 1984-1988, 2009-09-23
… Administration of ethionine to female rats caused a rapid and severe decline in liver ATP and inhibited hepatic protein synthesis in association with hypophosphorylation of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 70-kDa ribosomal protein S6 kinase (S6K1), two key regulatory proteins involved in initiation of mRNA translation. …
NAID 10027545444