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1. ヘリコバクターピロリ菌感染と消化管悪性腫瘍の関連性 association between helicobacter pylori infection and gastrointestinal malignancy
2. 乾癬の病態生理 pathophysiology of psoriasis
3. 大腸癌および原発性硬化性胆管炎 colorectal cancer and primary sclerosing cholangitis
4. Confluent and reticulated papillomatosis
5. 血管新生阻害剤の概要 overview of angiogenesis inhibitors

English Journal

Histamine H4 receptor knockout mice display reduced inflammation in a chronic model of atopic dermatitis.

Rossbach K1, Schaper K2, Kloth Ch3, Gutzmer R2, Werfel T2, Kietzmann M1, Bäumer W1,4.
Allergy.Allergy.2016 Feb;71(2):189-97. doi: 10.1111/all.12779. Epub 2015 Nov 13.
BACKGROUND: The histamine H4 receptor (H4R) was brought into focus as a new therapeutic target for the treatment of allergic disorders such as atopic dermatitis (AD). H4R antagonists have already been tested in several animal models of AD, but these studies have yielded conflicting results.MATERIAL
PMID 26440543

Minocycline Inhibits Inflammation and Squamous Metaplasia of Conjunctival Tissue Culture in Airlift Conditions.

Xiao Q1, Tan Y, Lin Z, Zhou J, Zhou F, Liu Z, Tang L.
Cornea.Cornea.2016 Feb;35(2):249-56. doi: 10.1097/ICO.0000000000000687.
PURPOSE: Inflammation and squamous metaplasia is a common pathological process that occurs in many ocular surface diseases such as dry eye, Stevens-Johnson syndrome, mucous membrane pemphigoid, and chemical/thermal burns. At present, there is no ideal medicinal treatment for this abnormality. We rep
PMID 26583279

Aberrant Notch signalling contributes to hypertrophic scar formation by modulating the phenotype of keratinocytes.

Li B1, Gao C2, Diao JS3, Wang DL3, Chu FF3, Li Y3, Wang G1, Guo SZ3, Xia W4.
Experimental dermatology.Exp Dermatol.2016 Feb;25(2):137-42. doi: 10.1111/exd.12897. Epub 2016 Jan 20.
Hypertrophic scar (HS) is characterized by fibroblast hyperproliferation and excessive matrix deposition. Aberrant keratinocyte differentiation and their abnormal cytokine secretion are said to contribute to HS by activating fibroblasts. However, the signalling pathway causing the aberrant keratinoc
PMID 26566963