高フィブリノーゲン血症、高フィブリノゲン血症

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1. フィブリノゲンの異常 disorders of fibrinogen
2. 心血管疾患の危険因子の概要 overview of the possible risk factors for cardiovascular disease
3. 腎移植レシピエントにおける心血管疾患の危険因子 risk factors for cardiovascular disease in the renal transplant recipient
4. ネフローゼ症候群における腎静脈血栓症および凝固能亢進状態 renal vein thrombosis and hypercoagulable state in nephrotic syndrome
5. 静脈血栓症の原因の概要 overview of the causes of venous thrombosis

English Journal

Postinjury hyperfibrinogenemia compromises efficacy of heparin-based venous thromboembolism prophylaxis.

Harr JN, Moore EE, Chin TL, Ghasabyan A, Gonzalez E, Wohlauer MV, Sauaia A, Banerjee A, Silliman CC.Author information *Department of Surgery, University of Colorado Denver, Aurora; †Department of Surgery, Denver Health Medical Center, Denver; ‡Trauma Research Center and §Department of Pediatrics, University of Colorado Denver, Aurora; and ∥Research Department, Bonfils Blood Center, Denver, Colorado.AbstractBACKGROUND: Venous thromboembolism (VTE) prophylaxis remains debated following trauma, and recommendations have not been established. Although hyperfibrinogenemia is a marker of proinflammatory states, it also contributes to thrombus formation. Postinjury hyperfibrinogenemia is common, but the effect of hyperfibrinogenemia on VTE prophylaxis has not been fully elucidated. Therefore, we hypothesized that heparin is less effective for VTE prophylaxis following severe injury due to hyperfibrinogenemia.
Shock (Augusta, Ga.).Shock.2014 Jan;41(1):33-9. doi: 10.1097/SHK.0000000000000067.
BACKGROUND: Venous thromboembolism (VTE) prophylaxis remains debated following trauma, and recommendations have not been established. Although hyperfibrinogenemia is a marker of proinflammatory states, it also contributes to thrombus formation. Postinjury hyperfibrinogenemia is common, but the effec
PMID 24351527

Serum fibrinogen is an independent prognostic factor in operable nonsmall cell lung cancer.

Sheng L, Luo M, Sun X, Lin N, Mao W, Su D.Author information Department of Radiation Therapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China; Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.AbstractSerum fibrinogen converted to insoluble fibrin by activated thrombin, plays an important role in the coagulation system. Increased fibrinogen considerably influences cancer cell growth, progression and metastasis. In nonsmall cell lung cancer (NSCLC), however, the association between serum fibrinogen concentration and prognosis has not been fully examined. We enlisted 567 operable NSCLC patients in our study. Preoperative serum fibrinogen was measured by the Clauss method. The association of serum fibrinogen concentration with clinical pathological factors and patient outcome was evaluated. Survival analysis indicated that serum fibrinogen was an independent prognostic factor in operable NSCLC. Patients with hyperfibrinogenemia had an elevated risk of disease progression and death compared to patients with normal fibrinogen levels. The hazard ratio was 1.49 (95% confidence interval [CI] 1.07-2.05) for disease progression and 1.64 (95% CI 1.06-2.53) for death. The trend linking increasing fibrinogen levels with risk was also statistically significant for both outcomes (p < 0.05). These analyses were adjusted for patient age, sex, smoking behavior, disease stage, tumor grade and histology. Kaplan-Meier survival curves showed similar results. Preoperative serum fibrinogen is a novel independent prognostic biomarker in operable NSCLC.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Dec 1;133(11):2720-5. doi: 10.1002/ijc.28284. Epub 2013 Jun 14.
Serum fibrinogen converted to insoluble fibrin by activated thrombin, plays an important role in the coagulation system. Increased fibrinogen considerably influences cancer cell growth, progression and metastasis. In nonsmall cell lung cancer (NSCLC), however, the association between serum fibrinoge
PMID 23716344

Increased carbon monoxide production by hemeoxygenase-1 caused by device-mediated hemolysis: thrombotic phantom menace?

Nielsen VG, Pearson EC, Smith MC.Author information Department of Anesthesiology, The University of Arizona College of Medicine, Tucson, AZ, USA.AbstractReplacement of key components of the circulatory system with artificial devices has become the mainstay of therapy for conditions such as end-stage valvular disease or congestive heart failure. Unfortunately, device thrombosis and thromboembolic morbidity persist despite optimized anticoagulation. This work reviews the commonly known causes of device-associated thrombophilia, introduces recent literature concerning the effect of carbon monoxide on coagulation, and presents new patient data linking endogenously produced carbon monoxide with device-associated thrombosis. A new paradigm involving the interaction of red blood cell lysis-induced upregulation of hemoxygenase-1, increased endogenous carbon monoxide, hyperfibrinogenemia, and contact protein/microparticle-induced thrombin generation is presented.
Artificial organs.Artif Organs.2013 Nov;37(11):1008-14. doi: 10.1111/aor.12122. Epub 2013 Jul 19.
Replacement of key components of the circulatory system with artificial devices has become the mainstay of therapy for conditions such as end-stage valvular disease or congestive heart failure. Unfortunately, device thrombosis and thromboembolic morbidity persist despite optimized anticoagulation. T
PMID 23865494

Japanese Journal

高血圧高脂血症自然発症ラットにおける高フィブリノーゲン血症と高血圧および高脂血症合併モデルとしての有用性

Experimental animals 56(1), 1-10, 2007-01-01
NAID 10018453328

Development of Hyperfibrinogenemia in Spontaneously Hypertensive and Hyperlipidemic Rats: A Potentially Useful Animal Model as a Complication of Hypertension and Hyperlipidemia