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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/03 15:55:59」(JST)
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Hymecromone
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| Systematic (IUPAC) name |
| 7-Hydroxy-4-methylchromen-2-one |
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Legal status |
?
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| Identifiers |
| CAS number |
90-33-5 Y |
| ATC code |
A05AX02 |
| PubChem |
CID 5280567 |
| DrugBank |
DB07118 |
| ChemSpider |
4444190 Y |
| UNII |
3T5NG4Q468 Y |
| KEGG |
D00170 Y |
| ChEBI |
CHEBI:17224 Y |
| ChEMBL |
CHEMBL12208 Y |
| Synonyms |
4-Methylumbelliferone |
| Chemical data |
| Formula |
C10H8O3 |
| Mol. mass |
176.17 g/mol |
SMILES
- O=C/2Oc1cc(O)ccc1\C(=C\2)C
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InChI
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InChI=1S/C10H8O3/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5,11H,1H3 Y
Key:HSHNITRMYYLLCV-UHFFFAOYSA-N Y
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| Y (what is this?) (verify) |
Hymecromone (4-methylumbelliferone) is a drug used in bile therapy. It is used as choleretic and antispasmodic drugs and as a standard for the fluorometric determination of enzyme activity.
Hymecromone is a crystalline solid with a melting point of 194–195 °C. It is soluble in methanol and glacial acetic acid.
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Bile and liver therapy (A05)
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| Bile therapy |
- bile acid (Chenodeoxycholic acid
- Cholic acid
- Ursodeoxycholic acid)
- Obeticholic acid
- Nicotinyl methylamide
- Piprozolin
- Hymecromone
- Cyclobutyrol
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| Liver therapy |
- Arginine glutamate
- Silymarin
- Citiolone
- Epomediol
- Ornithine oxoglutarate
- Tidiacic arginine
- Glycyrrhizin
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anat (t, g, p)/phys/devp/enzy
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noco/cong/tumr, sysi/epon
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proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
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Types of coumarins
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| Aglycones |
- Aesculetin
- Ferujol
- Umbelliferone
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O-Methylated
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- Fraxetin
- Herniarin (7-O-Methylumbelliferone)
- Osthol
- Scopoletin (6-Methoxyumbelliferone)
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| glycosides |
- Aesculin (Esculetin 6-O-glucoside)
- Fraxin (Fraxetin glucoside)
- Skimmin (Umbelliferone 7-O-glucoside)
- Scopolin
- Umbelliferone 7-apiosylglucoside
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| derivatives |
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Furanocoumarins
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Aglycones
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- Angelicin
- Marmesin
- Psoralen
- Vaginol
- Xanthotoxol (8-Hydroxypsoralen)
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O-Methylated
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- Bergapten (5-methoxypsoralen)
- Isopimpinellin (5,8-Dimethoxypsoralene)
- Methoxsalen (8-Methoxypsoralen)
- Trioxsalen (2,5,9-Trimethylpsoralen)
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Furanocoumarin glycosides
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- Apterin (vaginol glucoside)
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Meroterpene furanocoumarin ether
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- Auraptene
- Bergamottin
- Imperatorin
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| Oligomers |
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| Synthetic |
- Acenocoumarol
- Coumatetralyl
- Ensaculin
- Ethyl biscoumacetate
- 4-Hydroxycoumarins
- Hymecromone
- Phenprocoumon
- Warfarin
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English Journal
- Effect of Lipolysis on Drug Release from Self-microemulsifying Drug Delivery Systems (SMEDDS) with Different Core/Shell Drug Location.
- Zhang J1, Lv Y, Zhao S, Wang B, Tan M, Xie H, Lv G, Ma X.
- AAPS PharmSciTech.AAPS PharmSciTech.2014 Feb 20. [Epub ahead of print]
- The objective of this study is to investigate the effect of lipolysis on the release of poorly water-soluble drug from SMEDDS in the perspective of drug core/shell location. For this purpose, four SMEDDS formulations with various core/shell properties were developed based on long-chain lipid or medi
- PMID 24554238
- A silk fibroin based hepatocarcinoma model and the assessment of the drug response in hyaluronan-binding protein 1 overexpressed HepG2 cells.
- Kundu B1, Saha P, Datta K, Kundu SC.
- Biomaterials.Biomaterials.2013 Dec;34(37):9462-74. doi: 10.1016/j.biomaterials.2013.08.047. Epub 2013 Sep 7.
- Microenvironment around tumor cells plays an important role in its malignancy or invasiveness. Hyaluronan (HA), a major component of extracellular matrix is found to be elevated in most of cancerous niche/microenvironment and performs regulatory role in the progression of tumors and metastasis. Over
- PMID 24016853
- Inhibition of hyaluronan synthesis in rats reduces renal ability to excrete fluid and electrolytes during acute hydration.
- Stridh S1, Palm F, Hansell P.
- Upsala journal of medical sciences.Ups J Med Sci.2013 Nov;118(4):217-21. doi: 10.3109/03009734.2013.834013. Epub 2013 Sep 9.
- BACKGROUND: Hyaluronan (HA) is the dominant glycosaminoglycan in the renomedullary interstitium. Renomedullary HA has been implicated in tubular fluid handling due to its water-attracting properties and the changes occurring in parallel to acute variations in the body hydration status.METHODS: HA pr
- PMID 24102146
Japanese Journal
- 胆のう・胆道疾患に対するAnetholtrithionの臨床評価--二重盲検法によるHymecromoneとの比較対照試験
- つわりと悪阻に対するHymecromoneの使用経験
Related Links
- Hymecromone (4-methylumbelliferone) is a drug used in bile therapy. It is used as choleretic and antispasmodic drugs and as a standard for the fluorometric determination of enzyme activity. Hymecromone is a crystalline solid with a melting ...