hydroxyethylrutoside

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/17 02:08:06」(JST)

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Hydroxyethylrutosides (oxerutins, O-beta-hydroxyethyl-rutosides, HR or HER) are hydroxyethyl acetylations of rutoside. It may refer to :

Monoxerutin
Dihydroxyethylrutoside
Troxerutin
Tetrahydroxyethylrutoside

Oxerutins are semisynthetic derivatives of plant constituents. Although they are closely related to the natural flavonoid rutin, hydroxyethylrutosides are not found in food. The only way to take them is in a supplement.^[1]

Health benefits

Relvène (1967 French version), Venoruton (1962 Swiss version), and Paroven are mixtures of hydroxyethyl rutinosides. Hydroxyethylrutosides are used in the treatment of chronic venous insufficiency^[2] and hypertensive microangiopathy.^[3] Oxerutins works by reducing leakage from the small blood vessels (capillaries).^[4]

Hydroxyethylrutosides have been used as an alternative to horse chestnut preparations (venostasin) containing aescin. Typical doses are in the order of 1,000 mg/day.^[5]

Effects of hydroxyethylrutosides against adriamycin-induced toxicity have been investigated in rats.^[6]

References

^ Oxerutins on healthlibrary.epnet.com
^ Frick, RW (2000). "Three treatments for chronic venous insufficiency: Escin, hydroxyethylrutoside, and Daflon". Angiology 51 (3): 197–205. doi:10.1177/000331970005100303. PMID 10744007.
^ Incandela, L; Belcaro, G; Renton, S; Desanctis, MT; Cesarone, MR; Bavera, P; Ippolito, E; Bucci, M et al. (2002). "HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: A prospective, placebo-controlled, randomized trial". Journal of cardiovascular pharmacology and therapeutics. 7 Suppl 1: S7–S10. doi:10.1177/107424840200700103. PMID 12011966.
^ Paroven on netdoctor.co.uk
^ The handbook of clinically tested herbal remedies, Volume 2 by Marilyn Barrett
^ Gulati, OP; Nordmann, H; Aellig, A; Maignan, MF; McGinness, J (1985). "Protective effects of O-(beta-hydroxyethyl)-rutosides (HR) against adriamycin-induced toxicity in rats". Archives internationales de pharmacodynamie et de therapie 273 (2): 323–34. PMID 4004421.

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English Journal

Troxerutin inhibits 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function.

Zhang ZF1, Shan Q1, Zhuang J2, Zhang YQ3, Wang X4, Fan SH5, Lu J5, Wu DM5, Hu B5, Zheng YL6.
Toxicology letters.Toxicol Lett.2015 Mar 18;233(3):246-57. doi: 10.1016/j.toxlet.2015.01.017. Epub 2015 Jan 29.
Proteasome dysfunction has been associated with the pathogeneses of a variety of diseases and with the neurotoxicities of environmental chemicals; however, whether proteasome dysfunction plays a role in the cellular toxicity of polybrominated diphenyl ethers (PBDEs) has not been investigated to date
PMID 25639565

The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD.

Lemmens KJ1, van de Wier B2, Koek GH3, Köhler E4, Drittij MJ2, van der Vijgh WJ2, Bast A2, Haenen GR5.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Jan 2;456(1):179-82. doi: 10.1016/j.bbrc.2014.11.055. Epub 2014 Nov 22.
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. An evidence-based pharmacological treatment for NAFLD is still lacking, but flavonoids have shown therapeutic potential. The present study was designed to investigate the effect of the flavonoid monoHER on the onset of NAFLD
PMID 25462563

[Prophylaxis of thrombohemorrhagic complications in surgical treatment of chemoresistant pulmonary tuberculosis].

Duzhyĭ ID, Kravets' OV, Hres'ko IIa, Iurchenko AV.
Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukraïny, Naukove tovarystvo khirurhiv Ukraïny.Klin Khir.2014 Oct;(10):44-7.
Analysis of thrombohemorrhagic complications was conducted in 98 patients, operated on for various forms of chemoresistant pulmonary tuberculosis. To prevent such complications it is necessary to prescribe heparin in minimal doses or fraxiparine preoperatively and intraoperatively. It permits to low
PMID 25675787

Related Pictures

[1] Oxerutins on healthlibrary.epnet.com

[2] Frick, RW (2000). "Three treatments for chronic venous insufficiency: Escin, hydroxyethylrutoside, and Daflon". Angiology 51 (3): 197–205. doi:10.1177/000331970005100303. PMID 10744007.

[3] Incandela, L; Belcaro, G; Renton, S; Desanctis, MT; Cesarone, MR; Bavera, P; Ippolito, E; Bucci, M et al. (2002). "HR (Paroven, Venoruton; 0-(beta-hydroxyethyl)-rutosides) in venous hypertensive microangiopathy: A prospective, placebo-controlled, randomized trial". Journal of cardiovascular pharmacology and therapeutics. 7 Suppl 1: S7–S10. doi:10.1177/107424840200700103. PMID 12011966.

[4] Paroven on netdoctor.co.uk

[5] The handbook of clinically tested herbal remedies, Volume 2 by Marilyn Barrett

[6] Gulati, OP; Nordmann, H; Aellig, A; Maignan, MF; McGinness, J (1985). "Protective effects of O-(beta-hydroxyethyl)-rutosides (HR) against adriamycin-induced toxicity in rats". Archives internationales de pharmacodynamie et de therapie 273 (2): 323–34. PMID 4004421.

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