ヒドロキシコルチコステロイド
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English Journal
- Combination of fractional erbium-glass laser and topical therapy in melasma resistant to triple-combination cream.
- Tourlaki A1, Galimberti MG, Pellacani G, Bencini PL.Author information 1Istituto di Chirurgia e Laserchirurgia in Dermatologia (I.C.L.I.D.) , Milano , Italy.AbstractBACKGROUND: Melasma is a common melanosis often difficult to treat.
- The Journal of dermatological treatment.J Dermatolog Treat.2014 Jun;25(3):218-22. doi: 10.3109/09546634.2012.671911. Epub 2012 Apr 12.
- BACKGROUND: Melasma is a common melanosis often difficult to treat.OBJECTIVE: The aim of this paper was to report on the safety and efficacy of non-ablative fractional photothermolysis combined with the use of triple-combination cream (TCC) on a large population with melasma resistant (i.e., with no
- PMID 22385073
- Stratified control of IGF-I expression by hypoxia and stress hormones in osteoblasts.
- McCarthy TL1, Yun Z2, Madri JA3, Centrella M4.Author information 1Yale University School of Medicine, Department of Surgery, New Haven, CT 06520-8041, USA; Yale University School of Medicine, Department of Pathology, New Haven, CT 06520-8023, USA. Electronic address: thomas.mccarthy@yale.edu.2Yale University School of Medicine, Department of Therapeutic Radiology, New Haven, CT 06520-8040, USA.3Yale University School of Medicine, Department of Pathology, New Haven, CT 06520-8023, USA.4Yale University School of Medicine, Department of Surgery, New Haven, CT 06520-8041, USA; Yale University School of Medicine, Department of Pathology, New Haven, CT 06520-8023, USA. Electronic address: michael.centrella@yale.edu.AbstractBone cells respond to the integrated effects of local and systemic regulation. Here we show that hypoxia and the stress hormones PGE2 and glucocorticoid interact in complex ways in osteoblasts, converging on insulin like growth factor I (IGF-I) expression. Whereas hypoxia alone rapidly increased transcription factor HIF activity, it suppressed DNA synthesis, had no significant effects on protein synthesis or alkaline phosphatase activity, and drove discrete changes in a panel of osteoblast mRNAs. Notably, hypoxia increased expression of the acute phase response transcription factor C/EBPδ which can induce IGF-I in response to PGE2, but conversely prevented the stimulatory effect of PGE2 on IGF-I mRNA. However, unlike its effect on C/EBPδ, hypoxia suppressed expression of the obligate osteoblast transcription factor Runx2, which can activate an upstream response element in the IGF-I gene promoter. Hypoxic inhibition of IGF-I and Runx2 were enforced by glucocorticoid, and continued with prolonged exposure. Our studies thus reveal that IGF-I expression is stratified by two critical transcriptional elements in osteoblasts, which are resolved by the individual and combined effects of hypoxic stress and stress hormones. In so doing, hypoxia suppresses Runx2, limits the enhancing influence of PGE2, and interacts with glucocorticoid to reduce IGF-I expression by osteoblasts.
- Gene.Gene.2014 Apr 10;539(1):141-51. doi: 10.1016/j.gene.2014.01.011. Epub 2014 Jan 15.
- Bone cells respond to the integrated effects of local and systemic regulation. Here we show that hypoxia and the stress hormones PGE2 and glucocorticoid interact in complex ways in osteoblasts, converging on insulin like growth factor I (IGF-I) expression. Whereas hypoxia alone rapidly increased tra
- PMID 24440782
- Prevention: Before the break.
- Solis M.
- Nature.Nature.2014 Apr 3;508(7494):S12-3. doi: 10.1038/508S12a.
- PMID 24695328
Japanese Journal
- Stress in Children with Pervasive Developmental Disorders
- 道路輸送に対するサラブレッド馬のストレス反応,特に輸送熱に関して
- Journal of equine science = Continuation of Japanese Journal of Equine Science and Bulletin of Equine Research Institute 15(4), 99-102, 2004-12-01
- NAID 10014368859
- 実験的に実施した快-不快刺激の尿中17-KS、17-OHCS、唾液Cortisol値に及ぼす影響
Related Links
- 17-hydroxycorticosteroid (17-OHCS) is a product formed when the liver and other body tissues break down the steroid hormone, cortisol. This test can help determine if the body is producing too much of the hormone, cortisol. The test ...
- 17-hydroxycorticosteroid [-kôr′tikos′təroid] any steroid hydroxylated at carbon-17 secreted by adrenal glands and occasionally measured in the urine in a test for determining adrenal function and diagnosing hypoadrenalism or ...
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- hydroxycorticosteroid, OHCS
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