Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/21 23:59:01」(JST)

English Journal

Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines.

Liu L, Wagner CR, Hanna PE.SourceDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street SE, Minneapolis, Minnesota 55455, USA.
Chemical research in toxicology.Chem Res Toxicol.2009 Dec;22(12):1962-74. doi: 10.1021/tx9002676.
Human arylamine N-acetyltransferases (NATs) are expressed as two polymorphic isoforms, NAT1 and NAT2, that have toxicologically significant functions in the detoxification of xenobiotic arylamines by N-acetylation and in the bioactivation of N-arylhydroxylamines by O-acetylation. NAT1 also catalyzes
PMID 19842618

ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene.

McKinzie PB, Delongchamp RR, Chen T, Parsons BL.SourceDivision of Genetic and Reproductive Toxicology, HFT-120, 3900 NCTR Road, Jefferson, AR 72079, USA. page.mckinzie@fda.hhs.gov
Mutagenesis.Mutagenesis.2006 Nov;21(6):391-7. Epub 2006 Sep 29.
K-ras codon 12 GGT-->GAT and GGT-->GTT mutations are the most frequently observed K-ras point mutations in human and rodent tumors and therefore are implicated in carcinogenesis for many tissues. Measurement of these mutations in rat models and human tissue could facilitate a more logical extr
PMID 17012303

Mass spectrometric investigation of the mechanism of inactivation of hamster arylamine N-acetyltransferase 1 by N-hydroxy-2-acetylaminofluorene.

Guo Z, Wagner CR, Hanna PE.SourceDepartment of Medicinal Chemistry, University of Minnesota, 308 Harvard Street Southeast, Minneapolis, Minnesota 55455, USA.
Chemical research in toxicology.Chem Res Toxicol.2004 Mar;17(3):275-86.
Arylamine N-acetyltransferases (NATs) are expressed in most mammalian tissues. NATs catalyze the N-acetylation of primary arylamines, the O-acetylation of N-arylhydroxylamines, and the N,O-transacetylation of N-arylhydroxamic acids. The latter two reactions result in formation of reactive, electroph
PMID 15025497

リンク元	「ヒドロキシアセチルアミノフルオレン」

Hydroxyacetylaminofluorene
Names
	IUPAC name N-(9H-fluoren-2-yl)-N-hydroxyacetamide
	Other names N-Hydroxy-2-acetamidofluorene; Hydroxyfluorenylacetamide
Identifiers
CAS Registry Number	53-95-2
Jmol-3D images	Image
PubChem	5896
	SMILES CC(=O)N(C1=CC2=C(C=C1)C3=CC=CC=C3C2)O ;
Properties
Chemical formula	C15H13NO2
Molar mass	239.27 g/mol
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	verify (what is: /?)
	Infobox references