関: HERG

WordNet

pass, fare, or elapse; of a certain state of affairs or action; "How is it going?"; "The day went well until I got your call"
a time for working (after which you will be relieved by someone else); "its my go"; "a spell of work" (同)spell, tour, turn
be abolished or discarded; "These ugly billboards have to go!"; "These luxuries all had to go under the Khmer Rouge"
a board game for two players who place counters on a grid; the object is to surround and so capture the opponents counters (同)go game
move away from a place into another direction; "Go away before I start to cry"; "The train departs at noon" (同)go away, depart
lead, extend, or afford access; "This door goes to the basement"; "The road runs South" (同)lead
follow a procedure or take a course; "We should go farther in this matter"; "She went through a lot of trouble"; "go about the world in a certain manner"; "Messages must go through diplomatic channels" (同)proceed, move
be awarded; be allotted; "The first prize goes to Mary"; "Her money went on clothes"
be contained in; "How many times does 18 go into 54?"
be or continue to be in a certain condition; "The children went hungry that day"
be ranked or compare; "This violinist is as good as Juilliard-trained violinists go"
be sounded, played, or expressed; "How does this song go again?"
be spent; "All my money went for food and rent"
functioning correctly and ready for action; "all systems are go"
sing with closed lips; "She hummed a melody"
a humming noise; "the hum of distant traffic" (同)humming
be noisy with activity; "This office is buzzing with activity" (同)buzz, seethe
sound with a monotonous hum (同)thrum
make a low continuous sound; "The refrigerator is humming"
have or establish a relationship to; "She relates well to her peers"
be in a relationship with; "How are these two observations related?" (同)interrelate
give an account of; "The witness related the events"
relating to a person; "the experiment was conducted on 6 monkeys and 2 human subjects"
characteristic of humanity; "human nature"
having human form or attributes as opposed to those of animals or divine beings; "human beings"; "the human body"; "human kindness"; "human frailty"

PrepTutorEJDIC

《方向・場所を表す副詞[句]を伴って》『行く』,動く;(目的地に関係なく)進む,動く / (ある事をしに)『行く』: / 《副詞[句]を伴って》『立ち去る』,出かける,出発する / 〈機械などが〉(順調に)動く / 《副詞[句]を伴って》〈事が〉『運ぶ』,進展する / (ある状態に)『なる』,変わる / 《『go』+『名』(『形,過分』)〈補〉》(ある状態の)『ままである』 / (…から…に)向かっている,延びている《+『from』+『名』+『to』+『名』》(進行形にできない) / 〈賞品・財産などが〉(…の)ものとなる,(…の手に)渡る《+『to』+『名』》 / 〈金などが〉(…に)使用される,充当される》+『for』(『on,to』)+『名』》 / 有郊である,役立つ / 《副詞[句]を伴って》〈時間が〉過ぎる / 売られる,売れる / なくなる,つぶれる,死ぬ / 《must,can,have toと共に》捨てられる,無用にされる / 《副詞[句]を伴って》(あるべき場所に)位置する,納まる / 〈数量などが〉(…に)等しい《+『to』+『名』》;〈数が〉(…に)含まれる《+『into』+『名』》 / 《副詞[句]を伴って》音を出す,鳴る / 始める,行動に移る / 《副詞[句]を伴って》〈事が〉(…と)なっている(進行形にできない) / 《『as』+『名』+『go』の形で》普通…である,一般には…である / 《『go』『and』 do》《話》 / …しに行く / (愚かにも,不運にも)…をする / 《単なる強調で》…する / 《『go』『going』『to』 do》 / 《話している人の意志》(…する,させる)『つもりである』 / 《可能性・見込み》(…し)『そうである』 / 《近い未来》(…し)ようとしている / 《『go』 do『ing』》 / 《否定文・疑問文で》…するようなことをする / 《『go』+『名』》(…を,に) / 〈C〉行くこと,去ること,進行 / 〈U〉《話》活力,精力 / 〈C〉《話》試し,試み / 〈C〉《単数形で》(ゲームなどでの)番,順番
〈ハチ・機械などが〉『ブンブンいう』,ブーンと鳴る / 『鼻歌を歌う』,ハミングスル / (ちゅうちょ・当惑で)ふむふむいう / 《話》〈雰囲気・事業などが〉活気がある,活発に動く;(…で)活気づく《+『with』+『名』》 / …‘を'『ハミングで歌う』,鼻歌を歌って…‘を'(ある状熊に)する / (ハチ・機械などの)『ブンブン』[『うなる音』];鼻歌 / (雑踏などの)ガヤガヤ]いう音],騒音 / ふ‐む,う‐ん(ちゅうちょ・当惑・黙考・疑惑・不快などの声)
(…に)〈事件・事情など〉‘を'『物語る』《+『名』+『to』+『名』》 / (…と)…‘を'『関係させる』,結びつける《+『名』+『to(with)』+『名』》 / 〈物・事が〉(…に)関係がある,かかわる《+『to(with)』+『名(wh・節・句)』》 / (…に)〈人が〉なじむ,順応する《+『to』+『名』》
(…と)『同じくらい』,『同様に』 / 《比較》『…ほど』,『…くらい』,…ように / 《様態・程度》『…のように』,…と同じように / 《時》『…のときに』(when);…の間に,…するうちに(while) / 《話》《原因・理由》『…だから』,…なので / 《譲歩》《文》…だけれども(though) / 《先行する名詞の内容を制限して》『…のような』 / 《先行の,または後続の節の内容を受けて》『それは…だが』,…のように / 《役割・資格・機能などを表して》『…として』 / 《seem,appear,consider,pass,regard,treat,know,think of などの動詞の後で補語の働きをする語の前に置いて》…と[して] / 《前置詞・形容詞・分詞などの前に置いてその意味を限定して》…として[の],…とみなして,…と考えて / たとえば(for instance)
(動物・神に対して)『人間の』,人の / 『人間らいし』,人間的な,人情味のある / 〈C〉《複数形》(動物に怠して)人間(human being) / 〈U〉《the human》人類

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English Journal

3D-SDAR modeling of hERG potassium channel affinity: A case study in model design and toxicophore identification.

Stoyanova-Slavova IB1, Slavov SH2, Buzatu DA2, Beger RD2, Wilkes JG2.
Journal of molecular graphics & modelling.J Mol Graph Model.2017 Mar;72:246-255. doi: 10.1016/j.jmgm.2017.01.012. Epub 2017 Jan 16.
A dataset of 237 human Ether-à-go-go Related Gene (hERG) potassium channel inhibitors (180 of which were used for model building and validation, whereas 57 constituted the "true" external prediction set) collected from 22 literature sources was modeled by 3D-SDAR. To produce reliable and reproduci
PMID 28129595

Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels.

Hantouche C1,2, Williamson B3,2, Valinsky WC1,2, Solomon J1,2, Shrier A4,2, Young JC5,2.
The Journal of biological chemistry.J Biol Chem.2017 Feb 10;292(6):2287-2300. doi: 10.1074/jbc.M116.752618. Epub 2016 Dec 20.
Cardiac long QT syndrome type 2 is caused by mutations in the human ether a go-go-related gene (hERG) potassium channel, many of which cause misfolding and degradation at the endoplasmic reticulum instead of normal trafficking to the cell surface. The Hsc70/Hsp70 chaperones assist the folding of the
PMID 27998983

Improving the In Silico Assessment of Proarrhythmia Risk by Combining hERG (Human Ether-à-go-go-Related Gene) Channel-Drug Binding Kinetics and Multichannel Pharmacology.

Li Z1, Dutta S2, Sheng J2, Tran PN2, Wu W2, Chang K2, Mdluli T2, Strauss DG2, Colatsky T2.
Circulation. Arrhythmia and electrophysiology.Circ Arrhythm Electrophysiol.2017 Feb;10(2):e004628. doi: 10.1161/CIRCEP.116.004628.
BACKGROUND: The current proarrhythmia safety testing paradigm, although highly efficient in preventing new torsadogenic drugs from entering the market, has important limitations that can restrict the development and use of valuable new therapeutics. The CiPA (Comprehensive in vitro Proarrhythmia Ass
PMID 28202629

Japanese Journal

Blocking of the Human Ether-a-go-go-Related Gene Channel by Imatinib Mesylate

Dong Qian,Fu Xiao-xing,Du Li-li [他]
Biological & pharmaceutical bulletin 36(2), 268-275, 2013-02-00
NAID 40019558534

Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts

Asayama Mahoko,Kurokawa Junko,Shirakawa Kiyoshi,Okuyama Hisashi,Kagawa Toshiki,Okada Jun-ichi,Sugiura Seiryo,Hisada Toshiaki,Furukawa Tetsushi
Journal of Pharmacological Sciences, 2012
… In short QT syndrome, inherited gain-of-function mutations in the human <I>ether a-go-go-related</I> … gene (hERG) K<SUP>+</SUP> … This implies that drugs that activate hERG as a side effect may likewise pose significant arrhythmia risk. …
NAID 130002507898

Blockade of K+ and Ca2+ Channels by Azole Antifungal Agents in Neonatal Rat Ventricular Myocytes

Sung Dong-Jun,Kim Jae-Gon,Won Kyung Jong [他],Kim Bokyung,Shin Ho Chul,Park Jae-Yong,Bae Young Min
Biological and Pharmaceutical Bulletin 35(9), 1469-1475, 2012
… Although composite functions of ion channels in cardiomyocytes contribute to the shaping of action potentials, information on the effects of azole antifungal agents on ion currents, except human-ether-a-go-go-related gene (HERG) K+ currents, is largely lacking. …
NAID 130001872067