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English Journal

Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains.

Jennings EM1, Okine BN1, Olango WM1, Roche M2, Finn DP3.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2016 Jan 4;64:181-9. doi: 10.1016/j.pnpbp.2015.05.008. Epub 2015 May 16.
Repeated exposure to a homotypic stressor such as forced swimming enhances nociceptive responding in rats. However, the influence of genetic background on this stress-induced hyperalgesia is poorly understood. The aim of the present study was to compare the effects of repeated forced swim stress on
PMID 25988529

A bispecific antibody directly induces lymphoma cell death by simultaneously targeting CD20 and HLA-DR.

Zeng J1,2, Liu R3, Wang J3, Fang Y4.
Journal of cancer research and clinical oncology.J Cancer Res Clin Oncol.2015 Nov;141(11):1899-907. doi: 10.1007/s00432-015-1949-7. Epub 2015 Mar 14.
PURPOSE: Both CD20 and HLA-DR antigens are highly expressed on a variety of B-cell lymphomas and are therapeutic targets in antibody-based lymphoma therapy. The aim of this study was to evaluate the anti-tumor effect of a bispecific antibody CD20-HLA-DR DVD-Ig on B-cell lymphoma.METHODS: The gene fo
PMID 25773122

Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic.

Wen X1, Cao D2, Jones RW3, Hoshino Y3, Yuan L2.
Human vaccines & immunotherapeutics.Hum Vaccin Immunother.2015 Oct 3;11(10):2483-2489.
The two currently available live oral rotavirus vaccines, Rotarix® and RotaTeq®, are highly efficacious in the developed countries. However, the efficacy of such vaccines in resource deprived countries in Africa and Southeast Asia is low. We reported previously that a bacterially-expressed rotavir
PMID 26091081

Schizosaccharomyces pombe Pep12p is required for vacuolar protein transport and vacuolar homotypic fusion

萩原真,小林謙一,田所忠弘,山本祐司
東京農業大学農学集報 53(4), 322-326, 2009-03-16
低分子量Gタンパク質Rab5は細胞膜から初期エンドソームへの小胞輸送や初期エンドソーム同士の融合に関与する因子であることが知られている。過去の報告では,GTPγSなどの加水分解耐性GTPアナログを使用しFar-western blottingを行うことによってRab5結合因子が検出されている。しかしながら,この方法ではNEおよびNS反応の際に多量の加水分解耐性GTPアナログが必要であり,実験時間や …
NAID 110007106070