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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/20 15:40:30」(JST)
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"Dimerize" redirects here. For other uses, see Dimer.
Cartoon diagram of a dimer of Escherichia coli galactose-1-phosphate uridylyltransferase (GALT) in complex with UDP-galactose (stick models). Potassium, zinc, and iron ions are visible as purple, gray, and bronze-colored spheres respectively.
In biochemistry, a dimer is a macromolecular complex formed by two, usually non-covalently bound, macromolecules such as proteins or nucleic acids. It is a quaternary structure of a protein.
A homodimer is formed by two identical molecules (a process called homodimerisation). A heterodimer is formed by two different macromolecules (called heterodimerisation).
Most dimers in biochemistry are not connected by covalent bonds. An example of a non-covalent heterodimer is the enzyme reverse transcriptase, which is composed of two different amino acid chains.[1] An exception is dimers that are linked by disulfide bridges such as the homodimeric protein NEMO.[2]
Some proteins contain specialized domains to ensure dimerization (dimerization domains).
Examples
- Antibodies
- Receptor tyrosine kinases
- Transcription factors
- Leucine zipper motif proteins
- Nuclear receptors
- 14-3-3 proteins
- G protein-coupled receptors
- G protein βγ-subunit dimer
- Kinesin
- Triosephosphateisomerase (TIM)
- Alcohol dehydrogenase
- Factor XI
- Factor XIII
- Toll-like receptor
- Fibrinogen
- Variable surface glycoproteins of the Trypanosoma parasite
References
- ^ Sluis-Cremer N, Hamamouch N, San Félix A, Velazquez S, Balzarini J, Camarasa MJ (August 2006). "Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization". J. Med. Chem. 49 (16): 4834–41. doi:10.1021/jm0604575. PMID 16884295.
- ^ Herscovitch M, Comb W, Ennis T, Coleman K, Yong S, Armstead B, Kalaitzidis D, Chandani S, Gilmore TD (February 2008). "Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347". Biochemical and Biophysical Research Communications 367 (1): 103–8. doi:10.1016/j.bbrc.2007.12.123. PMC 2277332. PMID 18164680.
See also
- Dimer (chemistry)
- Protein trimer
- Oligomer
- ProtCID
- Molecular and cellular biology portal
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English Journal
- Expression of soluble, glycosylated and correctly folded dengue virus NS1 protein in Pichia pastoris.
- Allonso D, Pereira IB, Alves AM, Kurtenbach E, Mohana-Borges R.
- Protein expression and purification. 2019 Oct;162()9-17.
- The dengue virus (DENV) non structural protein 1 (NS1) is a 46-55 kDa protein that exists as homodimer inside cells and as hexamer in the extracellular milieu. Several lines of evidence have demonstrated that the biochemical and structural properties of recombinant NS1 (rNS1) vary depending on the
- PMID 31077812
- Structural and DNA-binding studies of the PadR-like transcriptional regulator BC1756 from Bacillus cereus.
- Kim TH, Park SC, Lee KC, Song WS, Yoon SI.
- Biochemical and biophysical research communications. 2019 Aug;515(4)607-613.
- Transcription factors that belong to the PadR family play an essential role in the transcriptional regulation of diverse biological processes by recognizing their cognate palindromic DNA sequences. Bacillus cereus harbors a gene that encodes a PadR-like protein (bcPLP; BC1756). bcPLP has not been st
- PMID 31178139
- Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub.
- Yuan W, Ibáñez CF, Lin Z.
- Biological reviews of the Cambridge Philosophical Society. 2019 Aug;94(4)1282-1293.
- The death domain (DD) is a globular protein motif with a signature feature of an all-helical Greek-key motif. It is a primary mediator of a variety of biological activities, including apoptosis, cell survival and cytoskeletal changes, which are related to many neurodegenerative diseases, neurotrauma
- PMID 30762293
Japanese Journal
- Characterization of Proanthocyanidin Oligomers of Ephedra sinica
- A Quantitative Study of Internal and External Interactions of Homodimeric Glucocorticoid Receptor Using Fluorescence Cross-Correlation Spectroscopy in a Live Cell
- 自然免疫の異物識別機構への理解を促すTLRカードゲームの開発<数学・自然科学>
- 埼玉大学紀要. 教育学部 = Journal of Saitama University. Faculty of Education 65(2), 261-270, 2016
- NAID 120006389408
Related Links
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★リンクテーブル★
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- 英
- homodimer、homodimeric
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- ホモ二量体、ヘテロダイマー
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- 英
- homodimer、homodimeric
- 関
- ホモダイマー
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- 関
- homodimerize
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- 関
- homodimer
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- homodimerization