English Journal

Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models.

Schultz L1, Zurich MG2, Culot M3, da Costa A3, Landry C3, Bellwon P4, Kristl T5, Hörmann K5, Ruzek S5, Aiche S6, Reinert K6, Bielow C6, Gosselet F3, Cecchelli R3, Huber CG5, Schroeder OH7, Gramowski-Voss A8, Weiss DG8, Bal-Price A9.
Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2015 Dec 25;30(1 Pt A):138-65. doi: 10.1016/j.tiv.2015.05.016. Epub 2015 May 27.
The present study was performed in an attempt to develop an in vitro integrated testing strategy (ITS) to evaluate drug-induced neurotoxicity. A number of endpoints were analyzed using two complementary brain cell culture models and an in vitro blood-brain barrier (BBB) model after single and repeat
PMID 26026931

MiR-205 and MiR-375 microRNA assays to distinguish squamous cell carcinoma from adenocarcinoma in lung cancer biopsies.

Patnaik S1, Mallick R, Kannisto E, Sharma R, Bshara W, Yendamuri S, Dhillon SS.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.J Thorac Oncol.2015 Mar;10(3):446-53. doi: 10.1097/JTO.0000000000000423.
INTRODUCTION: Identification of adenocarcinoma (AC) and squamous cell carcinoma (SCC) histology of non-small-cell lung cancer (NSCLC) in biopsies is clinically important but can be inaccurate by routine histopathologic examination. We quantify this inaccuracy at a cancer center, and evaluate the uti
PMID 25695220

Repeated exposure to Ochratoxin A generates a neuroinflammatory response, characterized by neurodegenerative M1 microglial phenotype.

von Tobel JS1, Antinori P2, Zurich MG3, Rosset R4, Aschner M5, Glück F2, Scherl A2, Monnet-Tschudi F3.
Neurotoxicology.Neurotoxicology.2014 Sep;44:61-70. doi: 10.1016/j.neuro.2014.04.005. Epub 2014 May 2.
Neurotoxic effects of the environmentally abundant mycotoxin Ochratoxin A (OTA) were studied in histotypic 3D rat brain cell cultures, comprising all brain cell types. Cultures were exposed to nanomolar OTA concentrations and samples were collected 48h after a single exposure, or after 10 days of re
PMID 24792326