The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin's interaction with Dishevelled.
Mendoza-Topaz C1, Mieszczanek J, Bienz M.
Open biology.Open Biol.2011 Nov;1(3):110013. doi: 10.1098/rsob.110013.
Most cases of colorectal cancer are linked to mutational inactivation of the Adenomatous polyposis coli (APC) tumour suppressor. APC downregulates Wnt signalling by enabling Axin to promote the degradation of the Wnt signalling effector β-catenin (Armadillo in flies). This depends on Axin's DIX dom
GTP-dependent heteropolymer formation and bundling of chloroplast FtsZ1 and FtsZ2.
Olson BJ1, Wang Q, Osteryoung KW.
The Journal of biological chemistry.J Biol Chem.2010 Jul 2;285(27):20634-43. doi: 10.1074/jbc.M110.122614. Epub 2010 Apr 26.
Bacteria and chloroplasts require the ring-forming cytoskeletal protein FtsZ for division. Although bacteria accomplish division with a single FtsZ, plant chloroplasts require two FtsZ types for division, FtsZ1 and FtsZ2. These proteins colocalize to a mid-plastid Z ring, but their biochemical relat
Atypical P2X receptor pharmacology in two human osteoblast-like cell lines.
Alqallaf SM1, Evans BA, Kidd EJ.
British journal of pharmacology.Br J Pharmacol.2009 Apr;156(7):1124-35. doi: 10.1111/j.1476-5381.2009.00119.x. Epub 2009 Feb 18.
BACKGROUND AND PURPOSE: The expression and function of P2X(7) receptors in osteoclasts is well established, but less is known about their role in osteoblast-like cells. A study in P2X(7) receptor knockout mice suggested the involvement of these receptors in bone formation. We have investigated the e
Heteropolymerization of S, I, and Z α 1-antitrypsin and liver cirrhosis Ravi Mahadeva, 1 Wun-Shaing W. Chang, 1 Timothy R. Dafforn, 1 Diana J. Oakley, 4 Richard C. Foreman, 4 Jacqueline Calvin, 2 Derek G.D. Wight, 3 and 1 ...
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