WordNet

a message whose ingenuity or verbal skill or incongruity has the power to evoke laughter (同)humor, humour, witticism, wittiness
a rise in the temperature of the body; frequently a symptom of infection (同)febrility, febricity, pyrexia, feverishness
intense nervous anticipation; "in a fever of resentment"
a pattern of symptoms indicative of some disease
a complex of concurrent things; "every word has a syndrome of meanings"
highly excited; "a fevered imagination"

PrepTutorEJDIC

《随伴・協調》…『と』,と共に,といっしょに / 《所有・所持》…『を持っている』,がある,の付いた / 《道具・手段》…『で』,を使って / 《財料・供給物》…『で』,を与えて / …を支持して,に賛成して / …『に反対(敵対)して』,を相手として / …『と同時に』,と同様に / …『に比べて』,に比例して / 《様態》《名詞を伴い副詞句として》『…で』,を示して,をもって / 《付帯状競》…『して』,しながら / 《譲歩》…がありながら,にもかかわらず / 『…が原因で』,のために,…で / …に任せて,のもとにあずけて,のところに / …に関して,について / …から離れて / 《連結・混合》…と / 《副詞と共に命令文で》
知る(know)
〈U〉『機知』,機転,ウィット / 〈C〉『機知に富む人』,機転のきく人 / 《複数形で;単数扱い》『理解(表現)力』,知性 / 《複数形で》(物事を見抜いたりもくろんだりする)才覚,才知 / 《複数形で;単数扱い》正気
〈U〉《しばしばa fever》(身体の異常な)『熱』,発熱 / 〈U〉『熱病』 / 〈U〉〈C〉(…に対する)『興奮』,熱狂《+『for』+『名』》
(疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
(比較変化なし)《名詞の前にのみ用いて》熱のある,熱病にかかった / 熱にうかされたような,興奮した / (憎しみなどが)異常に強い

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/19 13:50:36」(JST)

wiki en

Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses caused by species of hantaviruses from the family Bunyaviridae. It is also known as Korean hemorrhagic fever, epidemic hemorrhagic fever, and nephropathis epidemica. The species that cause HFRS include Hantaan River virus, Dobrava-Belgrade, Saaremaa, Seoul, Puumala and other hantaviruses. It is found in Europe, Asia, and Africa.^[1] Of these species, Hantaan River virus and Dobrava-Belgrade virus cause the most severe form of the syndrome and have the highest morbidity rates.

Both hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) appear to be immunopathologic, and inflammatory mediators are important in causing the clinical manifestations.

Signs and symptoms

Symptoms of HFRS usually develop within 1 to 2 weeks after exposure to infectious material, but in rare cases, they may take up to 8 weeks to develop. Initial symptoms begin suddenly and include intense headaches, back and abdominal pain, fever, chills, nausea, and blurred vision. Individuals may have flushing of the face, inflammation or redness of the eyes, or a rash. Later symptoms can include low blood pressure, acute shock, vascular leakage, and acute kidney failure, which can cause severe fluid overload.

The severity of the disease varies depending upon the virus causing the infection. Hantaan and Dobrava virus infections usually cause severe symptoms, while Seoul, Saaremaa, and Puumala virus infections are usually more moderate. Complete recovery can take weeks or months.^[2]

The course of the illness can be split into five phases:

Febrile phase: Symptoms include redness of cheeks and nose, fever, chills, sweaty palms, diarrhea, malaise, headaches, nausea, abdominal and back pain, respiratory problems such as the ones common in the influenza virus, as well as gastro-intestinal problems. These symptoms normally occur for three to seven days and arise about two to three weeks after exposure.

Hypotensive phase: This occurs when the blood platelet levels drop and symptoms can lead to tachycardia and hypoxemia. This phase can last for 2 days.

Oliguric phase: This phase lasts for three to seven days and is characterised by the onset of renal failure and proteinuria.

Diuretic phase: This is characterized by diuresis of three to six litres per day, which can last for a couple of days up to weeks.

Convalescent phase: This is normally when recovery occurs and symptoms begin to improve.

This syndrome can also be fatal. In some cases, it has been known to cause permanent renal failure.^[3]

Transmission

Transmission by aerosolized rodent excreta still remains the only known way the virus is transmitted to humans. In general, droplet and/or fomite transfer has not been shown in the hantaviruses in either the pulmonary or hemorrhagic forms.^[4]^[5]

Diagnosis

HFRS is difficult to diagnose on clinical grounds alone and serological evidence is often needed. A fourfold rise in IgG antibody titer in a 1-week interval, and the presence of the IgM type of antibodies against hantaviruses are good evidence for an acute hantavirus infection. HFRS should be suspected in patients with acute febrile flu-like illness, kidney failure of unknown origin and sometimes liver dysfunction.^[6]

Treatment

There is no cure or vaccine for HFRS. Treatment involves supportive therapy including renal dialysis. Treatment with ribavirin in China and Korea, administered within 7 days of onset of fever, resulted in a reduced mortality as well as shortened course of illness.^[7]

Prevention

Rodent control in and around the home remains the primary prevention strategy, as well as eliminating contact with rodents in the workplace and campsite. Closed storage sheds and cabins are often ideal sites for rodent infestations. Airing out of such spaces prior to use is recommended. Avoid direct contact with rodent droppings and wear a mask to avoid inhalation of aerosolized rodent secretions.^[8]

Epidemiology

HFRS is primarily a Eurasian disease, whereas HPS appears to be confined to the Americas. The geography is directly related to the indigenous rodent hosts and the viruses that coevolved with them.^[9]

References

^ Cosgriff TM, Lewis RM. Mechanisms of disease in hemorrhagic fever with renal syndrome. Kidney Int Suppl 1991; 35:S72.
^ Lee HW, van der Groen G. Hemorrhagic fever with renal syndrome. Prog Med Virol. 1989;36:62-102.
^ "[Acute kidney failure caused by Hantaviruses]. [Ther Umsch. 1994] - PubMed - NCBI". Ncbi.nlm.nih.gov. 2013-01-30. Retrieved 2013-04-13.
^ Peters, C.J. (2006). "Emerging Infections: Lessons from the Viral Hemorrhagic Fevers". Transactions of the American Clinical and Climatological Association (Transactions of the American Clinical and Climatological Association) 117: 189–197.
^ Crowley, J.; Crusberg, T. "Ebola and Marburg Virus Genomic Structure, Comparative and Molecular Biology". Dept. of Biology & Biotechnology, Worcester Polytechnic Institute.
^ Peters CJ, Simpson GL, Levy H. Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome.Annu Rev Med. 1999;50:531-45.
^ Lee HW, van der Groen G. Hemorrhagic fever with renal syndrome. Prog Med Virol. 1989;36:62-102.
^ "CDC - Hantavirus Pulmonary Syndrome (HPS) - Hantavirus". Cdc.gov. 2013-02-06. Retrieved 2013-07-07.
^ Peters CJ, Simpson GL, Levy H. Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome.Annu Rev Med. 1999;50:531-45.

External links

Sloan Science and Film / Short Films / Muerto Canyon by Jen Peel 29 minutes
"Hantaviruses, with emphasis on Four Corners Hantavirus" by Brian Hjelle, M.D., Department of Pathology, School of Medicine, University of New Mexico
CDC's Hantavirus Technical Information Index page
Viralzone: Hantavirus
Virus Pathogen Database and Analysis Resource (ViPR): Bunyaviridae
Occurrences and deaths in North and South America

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ハンタウイルス感染による腎疾患（腎症候性出血熱） renal involvement with hantavirus infection hemorrhagic fever with renal syndrome
2. ハンタウイルス感染の疫学および診断 epidemiology and diagnosis of hantavirus infections
3. ハンタウイルス感染の病因 pathogenesis of hantavirus infections
4. ハンタウイルス心肺症候群 hantavirus cardiopulmonary syndrome
5. 東アジアへの旅行によって感染する可能性のある疾患 diseases potentially acquired by travel to east asia

English Journal

History of incomplete vaccination may associate with occurrence of hemorrhagic fever with renal syndrome with relieved clinical symptoms.

Chen Y1, Yang X1, Ye F1, Chen T1, Liu Z1, Zhao Y1.
Journal of medical virology.J Med Virol.2015 Dec 4. doi: 10.1002/jmv.24443. [Epub ahead of print]
OBJECTIVE: This retrospective study is aimed to investigate the clinical features of the patients with history of incomplete vaccination against hemorrhagic fever with renal syndrome (HFRS).METHODS: Data of 140 cases of hospitalized patients with HFRS were collected. The patients were divided into i
PMID 26636561

Detection of different South American hantaviruses.

Guterres A1, de Oliveira RC2, Fernandes J2, Schrago CG3, de Lemos ER2.
Virus research.Virus Res.2015 Dec 2;210:106-13. doi: 10.1016/j.virusres.2015.07.022. Epub 2015 Jul 26.
Hantaviruses are the etiologic agents of Hemorrhagic Fever with Renal Syndrome (HFRS) in Old World, and Hantavirus Pulmonary Syndrome (HPS)/Hantavirus Cardiopulmonary Syndrome (HCPS), in the New World. Serological methods are the most common approach used for laboratory diagnosis of HCPS, however th
PMID 26220480

Life-Threatening Sochi Virus Infections, Russia.

Kruger DH, Tkachenko EA, Morozov VG, Yunicheva YV, Pilikova OM, Malkin G, Ishmukhametov AA, Heinemann P, Witkowski PT, Klempa B, Dzagurova TK.
Emerging infectious diseases.Emerg Infect Dis.2015 Dec;21(12):2204-8. doi: 10.3201/eid2112.150891.
Sochi virus was recently identified as a new hantavirus genotype carried by the Black Sea field mouse, Apodemus ponticus. We evaluated 62 patients in Russia with Sochi virus infection. Most clinical cases were severe, and the case-fatality rate was as high as 14.5%.
PMID 26584463

Japanese Journal

Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia

IBRAHIM Ima-Nurisa,SHIMIZU Kenta,YOSHIMATSU Kumiko [他],YUNIANTO Andre,SALWATI Ervi,YASUDA Shumpei P.,KOMA Takaaki,ENDO Rika,ARIKAWA Jiro
Journal of Veterinary Medical Science 75(8), 1003-1008, 2013
… Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne zoonotic disease caused by hantavirus infection. … Despite the high prevalence in rodents, human sera collected from 31 patients with fever of unknown origin and 20 healthy volunteers in the islands in 2009 did not show positive reaction to the antigen in IFA. …
NAID 130003362164

Diagnostic aspects for epidemic hemorrhage fever in legal medical autopsy : Report of 2 cases and review

ZHAO Rui,ZHU Bao-Li,GUAN Da-Wei,LI Ru-Bo,ZHANG Guo-Hua,WU Xu,WANG De-wen
Legal medicine 11, S541-S543, 2009-04-01
NAID 10027263792

Epidemiological Study of Hantavirus Infection in the Samara Region of European Russia

Kariwa Hiroaki,Tkachenko Evgeniy A.,Morozov Vyacheslav G. [他],SETO Takahiro,TANIKAWA Yoichi,KOLOMINOV Sergey I.,BELOV Sergey N.,NAKAMURA Ichiro,HASHIMOTO Nobuo,BALAKIEV Alexander E.,DZAGURNOVA Tamara K.,DAUD Nur Hardy bin Abu,MIYASHITA Daisuke,MEDVEDKINA Olga A.,NAKAUCHI Mina,ISHIZUKA Mariko,YOSHII Kentaro,YOSHIMATSU Kumiko,ARIKAWA Jiro,TAKASHIMA Ikuo
Journal of Veterinary Medical Science 71(12), 1569-1578, 2009
… European Russia is a highly endemic area of hemorrhagic fever with renal syndrome (HFRS), a rodent-borne zoonotic disease, caused by hantaviruses. …
NAID 130000149982

Related Pictures

★リンクテーブル★

リンク元	「腎症候性出血熱」「epidemic hemorrhagic fever」「HFRS」
拡張検索	「hemorrhagic fever with renal syndrome virus」
関連記事	「hemorrhagic」「renal」「hemorrhagic fever」「syndrome」

「腎症候性出血熱」

Hantavirus
	Transmission electron micrograph of the Sin Nombre Hantavirus
Virus classification
Group:	Group V ((-)ssRNA)
Order:	Unassigned
Family:	Bunyaviridae
Genus:	Hantavirus
Type species
	Hantaan virus;
Species
	Asama virus; Gou virus; Hantaan River virus; Dobrava-Belgrade virus; Saaremaa virus; Seoul virus; Puumala virus; Serang virus; Thailand virus; Thottapalayam virus; Nova virus

　　[★]

英: hemorrhagic fever with renal syndrome, haemorrhagic fever with renal syndrome, HFRS
関: ハンタウイルス; epidemic hemorrhagic fever、hemorrhagic fever with renal syndrome、nephropathia epidemica

「epidemic hemorrhagic fever」

　　[★]

流行性出血熱

関: hemorrhagic fever with renal syndrome、HFRS、nephropathia epidemica

「HFRS」

　　[★] 腎症候性出血熱 hemorrhagic fever with renal syndrome

「hemorrhagic fever with renal syndrome virus」

　　[★] 腎症候性出血熱ウイルス

「hemorrhagic」

　　[★]

adj.

出血性の、易出血性の

関: haemophilic、haemorrhagic、hemophilic

「renal」

　　[★]

adj.

腎臓の、腎性の、腎の

関: kidney、renally

「hemorrhagic fever」

　　[★] 出血熱

関: haemorrhagic fever

「syndrome」

　　[★]

n.

症候群

[1] Cosgriff TM, Lewis RM. Mechanisms of disease in hemorrhagic fever with renal syndrome. Kidney Int Suppl 1991; 35:S72.

[2] Lee HW, van der Groen G. Hemorrhagic fever with renal syndrome. Prog Med Virol. 1989;36:62-102.

[3] "[Acute kidney failure caused by Hantaviruses]. [Ther Umsch. 1994] - PubMed - NCBI". Ncbi.nlm.nih.gov. 2013-01-30. Retrieved 2013-04-13.

[4] Peters, C.J. (2006). "Emerging Infections: Lessons from the Viral Hemorrhagic Fevers". Transactions of the American Clinical and Climatological Association (Transactions of the American Clinical and Climatological Association) 117: 189–197.

[5] Crowley, J.; Crusberg, T. "Ebola and Marburg Virus Genomic Structure, Comparative and Molecular Biology". Dept. of Biology & Biotechnology, Worcester Polytechnic Institute.

[6] Peters CJ, Simpson GL, Levy H. Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome.Annu Rev Med. 1999;50:531-45.

[7] Lee HW, van der Groen G. Hemorrhagic fever with renal syndrome. Prog Med Virol. 1989;36:62-102.

[8] "CDC - Hantavirus Pulmonary Syndrome (HPS) - Hantavirus". Cdc.gov. 2013-02-06. Retrieved 2013-07-07.

[9] Peters CJ, Simpson GL, Levy H. Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome.Annu Rev Med. 1999;50:531-45.

匿名

検索

案内

案内

hemorrhagic fever with renal syndrome