関: ulobetasol

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/09/08 17:28:37」(JST)

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Ulobetasol (INN) or halobetasol (USAN) is a corticosteroid used to treat psoriasis. It is a group I corticosteroid under the US classification, the most potent class of such drugs. Halobetasol propionate is usually supplied as a 0.05% topical cream. Halobetasol is the strongest topical steroid available.^{[citation needed]}

External links

halobetasol at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Two Multicenter, Randomized, Double-Blind, Parallel Group Comparison Studies of a Novel Enhanced Lotion Formulation of Halobetasol Propionate, 0.05% Versus Its Vehicle in Adult Subjects With Plaque Psoriasis.

Pariser D, Bukhalo M, Guenthner S, Kempers S, Shideler S, Gold LS, Tschen E, Berg J, Ferdon MB, Dromgoole S.
Journal of drugs in dermatology : JDD.J Drugs Dermatol.2017 Mar 1;16(3):234-240.
<p>BACKGROUND: A novel lotion formulation of halobetasol propionate, 0.05% (HBP Lotion) with enhanced vehicle characteristics of a cream while preserving the ease of use and cosmetic elegance of a lotion has been developed to treat plaque psoriasis.OBJECTIVE: Determine the safety and effective
PMID 28301619

A Phase 2, Multicenter, Double-Blind, Randomized, Vehicle Controlled Clinical Study to Assess the Safety and Efficacy of a Halobetasol/Tazarotene Fixed Combination in the Treatment of Plaque Psoriasis.

Sugarman JL, Gold LS, Lebwohl MG, Pariser DM, Alexander BJ, Pillai R.
Journal of drugs in dermatology : JDD.J Drugs Dermatol.2017 Mar 1;16(3):197-204.
<p>BACKGROUND: Psoriasis is a chronic, immune-mediated disease that varies widely in its clinical expression. Treatment options focus on relieving symptoms, reducing inflammation, induration, and scaling, and controlling the extent of the disease. Topical corticosteroids are the mainstay of tr
PMID 28301614

Halobetasol Propionate Lotion, 0.05% Provides Superior Hydration Compared to Halobetasol Propionate Cream, 0.05% in a Double-Blinded Study of Occlusivity and Hydration.

Grove G, Zerweck C, Houser T, Andrasfay A, Gauthier B, Holland C, Piacquadio D.
Journal of drugs in dermatology : JDD.J Drugs Dermatol.2017 Feb 1;16(2):140-144.
BACKGROUND: This study measured skin hydration and occlusivity of two test products [halobetasol propionate lotion, 0.05% (HBP Lotion) and Ultravate® (halobetasol propionate) cream, 0.05% (HBP Cream)] at 2, 4, and 6 hours after application to skin test sites previously challenged by dry shaving, wh
PMID 28300856

Japanese Journal

Calcipotriene ointment and halobetasol ointment in the long-term treatment of psoriasis : effects on the duration of improvement

LEBWOHL M
J Am Acad Dermatol 39, 447-450, 1998
NAID 30016674113

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リンク元	「ハロベタソール」「ulobetasol」

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Ulobetasol
Clinical data
Synonyms	(6S,8S,9S,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a601060
ATC code	D07AC21 (WHO);
Identifiers
	IUPAC name (6α,11β,16β)-21-chloro-6,9-difluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione;
CAS Number	98651-66-2 ;
PubChem CID	5311167;
ChemSpider	4470691 ;
UNII	9P6159HM7T;
KEGG	D08660 ;
ChEMBL	CHEMBL1201360 ;
Chemical and physical data
Formula	C22H27ClF2O4
Molar mass	428.897
3D model (JSmol)	Interactive image;
	SMILES ClCC(=O)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@@H]3C)C)C ;
	InChI InChI=1S/C22H27ClF2O4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1 ; Key:LEHFPXVYPMWYQD-XHIJKXOTSA-N ;
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