- 関
- atrichia、atrichous、glabrous
WordNet
- having no hair or fur; "a Mexican Hairless is about the size of a fox terrier and hairless except for a tufts on the head and tail"
- having no hair or similar growth; smooth; "glabrous stems"; "glabrous leaves"; "a glabrous scalp"
- the condition of being void of hair (同)depilation
- the quality of not having hair
- any of an old breed of small nearly hairless dogs of Mexico
PrepTutorEJDIC
- 髪のない,はげの
- (動植物が)無毛の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/06/23 22:49:36」(JST)
[Wiki en表示]
This article is about Hairless. For the human medical condition Alopecia universalis, see Alopecia universalis.
Hairless, also known as H, is a well-characterized Drosophila gene.[1] Many mutations to hairless are embryonic lethal; however, there are several viable hairless mutants.[2] Hairless is involved in the Notch signaling pathway in Drosophila, acting as a suppressor of Notch signaling.[3]
Summary[edit]
Hairless (H) is a protein which is hydrophilic.[4]" The protein is composed of “1076 amino acids, with a molecular weight of 110 kDa.[4]” The H protein is reported in insects and is found in nearly all of the Drosophilidae family.[4] According to Paz-Gomez et. al. (2008), other insect families and orders containing the H protein include the Culicidae family as well as the Lepidoptera, Hymenoptera and Coleoptera orders.
By referencing the research of Paz-Gomez et. al. (2008), one finds that in Drosophilia, NSP, or Notch Signaling Pathway, allows for communication intercellularly during embryo development and also physiological activities of adult organisms. Their research also states that Notch Signaling Pathways turn on periodically during devolvement to help determine cell fate functions of the cell. Hairless (H) is an antagonist of the NSP as well as a “key member of the Su[H] repressor complex.[4]" Because of this connection, Hairless plays a very important part of embryo development in insects as it helps influence cell fate decisions during this time.[4]" It is crucial that proteins, HP120 and HP150, are present as they control normal activity of H.[4] This activity regulation also controls NSP, which allows the fly embryos to develop correctly and any fluctuation in the pathway or proteins can change outcome of the offspring.[4]
References[edit]
- ^ "Entrez Gene: Hairless".
- ^ "Fly Base: Hairless".
- ^ Maier D (2006). "Hairless: the ignored antagonist of the Notch signalling pathway". Hereditas 143.
- ^ a b c d e f g Paz-Gomez, D., Baizabal-Aguirre, V. M., Valdez-Alarcón, J., Cajero-Juárez, M., Nagel, A., Preiss, A., Maier, D., Bravo-Patiño, A. (2008). Structural analysis of point mutations in the Hairless gene and their association with the activity of the Hairless protein. International Journal of Biological Macromolecules, 43 (5). 426-432 doi: 10.1016/j.ijbiomac.2008.08.012
External links[edit]
- Society for Developmental Biology: Hairless.
- Kegg Pathway highlighting Hairless.
UpToDate Contents
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English Journal
- Non-invasive pH determination adjacent to degradable biomaterials in vivo.
- Bartsch I, Willbold E, Rosenhahn B, Witte F.SourceLaboratory for Biomechanics and Biomaterials, Department of Orthopaedic Surgery, Hannover Medical School, Anna-von-Borries-Straße 1-7, 30625 Hannover, Germany; CrossBIT, Center for Biocompatibility and Implant-Immunology, Department of Orthopaedic Surgery, Hannover Medical School, Feodor-Lynen-Straße 31, 30625 Hannover, Germany.
- Acta biomaterialia.Acta Biomater.2014 Jan;10(1):34-9. doi: 10.1016/j.actbio.2013.08.047. Epub 2013 Sep 8.
- An appropriate pH level is an important prerequisite for the physiologal functioning of cells and tissues. Changes in the extracellular pH often lead to specific cellular reactions and an altered metabolism of cells and tissues influences the extracellular pH range. Thus a method to monitor the extr
- PMID 24021229
- Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth.
- Higgins CA, Chen JC, Cerise JE, Jahoda CA, Christiano AM.SourceDepartments of Dermatology, Genetics and Development, and Systems Biology, Columbia University, New York, NY 10032.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Dec 3;110(49):19679-88. doi: 10.1073/pnas.1309970110. Epub 2013 Oct 21.
- De novo organ regeneration has been observed in several lower organisms, as well as rodents; however, demonstrating these regenerative properties in human cells and tissues has been challenging. In the hair follicle, rodent hair follicle-derived dermal cells can interact with local epithelia and ind
- PMID 24145441
- Mediation of muscular control of rhinarial motility in rats by the nasal cartilaginous skeleton.
- Haidarliu S, Kleinfeld D, Ahissar E.SourceDepartment of Neurobiology, the Weizmann Institute of Science, Rehovot, Israel.
- Anatomical record (Hoboken, N.J. : 2007).Anat Rec (Hoboken).2013 Dec;296(12):1821-32. doi: 10.1002/ar.22822. Epub 2013 Oct 29.
- The rhinarium is the rostral-most area of the snout that surrounds the nostrils, and is hairless in most mammals. In rodents, it participates in coordinated behaviors, active tactile sensing, and active olfactory sensing. In rats, the rhinarium is firmly connected to the nasal cartilages, and its mo
- PMID 24249396
- Clinical anatomical study and evaluation of the use of the free anteromedial thigh perforator flaps in reconstructions of the head and neck.
- Xu ZF, Sun CF, Duan WY, Zhang EJ, Dai W, Zheng XJ, Liu FY, Tan XX.SourceDepartment of Oromaxillofacial-Head and Neck Surgery, School of Stomatology, China Medical University, No. 117, Nanjing North Street, Heping District, Shenyang, Liaoning 110002, PR China; Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, No. 117, Nanjing North Street, Heping District, Shenyang, Liaoning 110002, PR China. Electronic address: xzf7090@hotmail.com.
- The British journal of oral & maxillofacial surgery.Br J Oral Maxillofac Surg.2013 Dec;51(8):725-30. doi: 10.1016/j.bjoms.2011.11.017. Epub 2011 Dec 20.
- The anteromedial thigh (AMT) perforator flap is usually thin, pliable, and nearly hairless, making it particularly suitable to repair defects of the head and neck. We studied the topography and outcomes of AMT perforator flaps in such defects after excision of tumours. We retrospectively reviewed th
- PMID 22192608
Japanese Journal
- Skin Permeation of Testosterone from Viscoelastic Lecithin Reverse Wormlike Micellar Solution
- Effect of Physiological Changes in the Skin on Systemic Absorption of Tacrolimus Following Topical Application in Rats
- Dietary milk sphingomyelin prevents disruption of skin barrier function in hairless mice after UV-B irradiation
- Molecularmechanisms of action of different concentrations of ethanol in water on ordered structures of intercellular lipids and soft keratin in the stratum corneum
- Biochimica et Biophysica Acta (BBA) - Biomembranes 1848(5), 1196-1202, 2015-05
- NAID 120005704658
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★リンクテーブル★
[★]
- 英
- atrichia、hairless、glabrous、atrichous
- 関
- 無毛症、無毛性
[★]
- 関
- atrichia、glabrous、hairless
[★]
無毛症、無毛
- 関
- atrichous、glabrous、hairless
[★]
- 関
- atrichia、atrichous、hairless
[★]
無毛マウス
- 関
- hairless mouse、inbred HRS mice