グアニル酸シクラーゼ活性化タンパク質
WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- causing motion or action or change (同)actuating
PrepTutorEJDIC
- 蛋白(たんばく)質
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/21 07:11:57」(JST)
[Wiki en表示]
For the drugs, see cinaciguat and riociguat.
A guanylate cyclase activator (or "GUCA") is one of group of proteins which upregulates guanylate cyclase. It is also known as guanylate cyclase-activating protein, with the abbreviation "GCAP".Mutations can be associated with vision defects.[1]
There are five genes involved:
- GUCA1A, GUCA1B, GUCA1C
- GUCA2A, GUCA2B
References
- ^ Payne AM, Downes SM, Bessant DA, et al. (1998). "A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1". Hum. Mol. Genet. 7 (2): 273–7. doi:10.1093/hmg/7.2.273. PMID 9425234.
External links
- Guanylate Cyclase-Activating Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
Eye proteins
|
|
Opsin (retinylidene protein) |
visual
|
- Rhodopsin
- Photopsin (OPN1LW
- OPN1MW/OPN1MW2
- OPN1SW)
|
|
nonvisual
|
- Melanopsin
- OPN3
- OPN5
- RRH
- RGR
|
|
|
Crystallin |
- Alpha (A
- B)
- Beta (A1
- A2
- A4
- B1
- B2
- B3)
- Gamma (A
- B
- C
- D
- N
- S)
|
|
Other |
- Arrestin
- Guanylate cyclase activator
- Recoverin
- Rhodopsin kinase
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- A Calcium-Relay Mechanism in Vertebrate Phototransduction.
- Koch KW, Dell'orco D.SourceDepartment of Neurosciences, Biochemistry Group, University of Oldenburg , Carl-von-Ossietzky-Strasse 9-11, D-26129 Oldenburg, Germany.
- ACS chemical neuroscience.ACS Chem Neurosci.2013 Mar 21. [Epub ahead of print]
- Calcium-signaling in cells requires a fine-tuned system of calcium-transport proteins involving ion channels, exchangers, and ion-pumps but also calcium-sensor proteins and their targets. Thus, control of physiological responses very often depends on incremental changes of the cytoplasmic calcium co
- PMID 23472635
- RNAi-Mediated Gene Suppression in a GCAP1(L151F) Cone-Rod Dystrophy Mouse Model.
- Jiang L, Li TZ, Boye SE, Hauswirth WW, Frederick JM, Baehr W.SourceDepartment of Ophthalmology and Visual Sciences, University of Utah Health Science Center, Salt Lake City, Utah, United States of America.
- PloS one.PLoS One.2013;8(3):e57676. doi: 10.1371/journal.pone.0057676. Epub 2013 Mar 5.
- Dominant mutations occurring in the high-affinity Ca(2+)-binding sites (EF-hands) of the GUCA1A gene encoding guanylate cyclase-activating protein 1 (GCAP1) cause slowly progressing cone-rod dystrophy (CORD) in a dozen families worldwide. We developed a nonallele-specific adeno-associated virus (AAV
- PMID 23472098
- Calcium feedback to cGMP synthesis strongly attenuates single-photon responses driven by long rhodopsin lifetimes.
- Gross OP, Pugh EN Jr, Burns ME.SourceCenter for Neuroscience, University of California, Davis, Davis, CA 95618, USA.
- Neuron.Neuron.2012 Oct 18;76(2):370-82. doi: 10.1016/j.neuron.2012.07.029. Epub 2012 Oct 17.
- Rod photoreceptors generate amplified, reproducible responses to single photons via a G protein signaling cascade. Surprisingly, genetic perturbations that dramatically alter the deactivation of the principal signal amplifier, the GPCR rhodopsin (R∗), do not much alter the amplitude of single-phot
- PMID 23083739
Japanese Journal
- A Model of the Intracellular Response of an Olfactory Neuron in Caenorhabditis elegans to Odor Stimulation
- Usuyama Mamoru,Ushida Chisato,Shingai Ryuzo
- PLOS ONE 7(8), e42907, 2012-08-23
- … Our model incorporated a G-protein-coupled odor receptor, a G-protein, a guanylate cyclase as the G-protein effector, and a single phosphodiesterase. …
- NAID 120005199326
- Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man
- Two Guanylate Cyclase Activating Proteins in Medaka Retina
- HONKAWA Hanayo,HISATOMI Osamu,KISHIDA Yoshihiro,TOKUNAGA Fumio
- Interdisciplinary Information Sciences 8(1), 25-32, 2002
- … Guanylate cyclase activating protein (GCAP1 and 2) is a Ca<SUP>2+</SUP>-sensitive regulator of the retinal membrane guanylate cyclases (GCs). …
- NAID 110000071752
Related Links
- 1. J Biol Chem. 1995 Sep 15;270(37):22029-36. Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction. Gorczyca WA(1), Polans AS, Surgucheva IG, Subbaraya I, Baehr W, Palczewski K. ...
- Synonyms Guanylyl cyclase–activating protein Historical Background The primary processes of vertebrate visual excitation are located in the rod and cone photoreceptor cells of the retina. Illumination of the rod and cone cells triggers ...
★リンクテーブル★
[★]
- 英
- guanylate cyclase-activating protein
[★]
シクラーゼ、サイクレース、環化酵素