グアノシン二リン酸
- 関
- GDP
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/11/13 19:03:19」(JST)
[Wiki en表示]
Guanosine diphosphate |
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Identifiers |
CAS number |
146-91-8 N |
PubChem |
730 |
ChemSpider |
8630 Y |
ChEBI |
CHEBI:17552 Y |
ChEMBL |
CHEMBL384759 Y |
IUPHAR ligand |
2410 |
Jmol-3D images |
Image 1 |
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C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)NC(=NC2=O)N
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InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1 Y
Key: QGWNDRXFNXRZMB-UUOKFMHZSA-N Y
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Properties |
Molecular formula |
C10H15N5O11P2 |
Molar mass |
443.200522 |
N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
Infobox references |
Guanosine diphosphate, abbreviated GDP, is a nucleoside diphosphate. It is an ester of pyrophosphoric acid with the nucleoside guanosine. GDP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase guanine.
GDP is the product of GTP dephosphorylation by GTPases, e.g., the G-proteins that are involved in signal transduction.
GDP is converted into GTP with the help of pyruvate kinase and phosphoenolpyruvate.
See also
- Nucleoside
- Nucleotide
- DNA
- RNA
- Oligonucleotide
- Guanosine triphosphate
Nucleic acid constituents
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Nucleobase |
Purine (Adenine, Guanine, Purine analogue) · Pyrimidine (Uracil, Thymine, Cytosine, Pyrimidine analogue)
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Nucleoside |
Ribonucleoside
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Adenosine · Guanosine · 5-Methyluridine · Uridine · Cytidine
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Deoxyribonucleoside
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Deoxyadenosine · Deoxyguanosine · Thymidine · Deoxyuridine · Deoxycytidine
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Nucleotide
(Nucleoside monophosphate) |
Ribonucleotide
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AMP, GMP, m5UMP, UMP, CMP
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Deoxyribonucleotide
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dAMP, dGMP, dTMP, dUMP, dCMP
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Cyclic nucleotide
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cAMP, cGMP, c-di-GMP, cADPR
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Nucleoside diphosphate |
ADP, GDP, m5UDP, UDP, CDP · dADP, dGDP, dTDP, dUDP, dCDP
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Nucleoside triphosphate |
ATP, GTP, m5UTP, UTP, CTP · dATP, dGTP, dTTP, dUTP, dCTP
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- biochemical families: proteins (amino acids/intermediates)
- nucleic acids (constituents/intermediates)
- carbohydrates (glycoproteins, alcohols, glycosides)
- lipids (fatty acids/intermediates, phospholipids, steroids, sphingolipids, eicosanoids)
- tetrapyrroles/intermediates
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UpToDate Contents
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English Journal
- Functional expression of L-fucokinase/guanosine 5'-diphosphate-L-fucose pyrophosphorylase from Bacteroides fragilis in Saccharomyces cerevisiae for the production of nucleotide sugars from exogenous monosaccharides.
- Liu TW, Ito H, Chiba Y, Kubota T, Sato T, Narimatsu H.SourceResearch Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Central-2 OSL, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan.
- Glycobiology.Glycobiology.2011 Sep;21(9):1228-36. Epub 2011 Apr 22.
- The biosynthesis of glycoconjugates requires the relevant glycosyltransferases and nucleotide sugars that can act as donors. Given the biological importance of posttranslational glycosylation, a facile, robust and cost-effective strategy for the synthesis of nucleotide sugars is highly desirable. In
- PMID 21515909
- Enhanced production of GDP-L: -fucose by overexpression of NADPH regenerator in recombinant Escherichia coli.
- Lee WH, Chin YW, Han NS, Kim MD, Seo JH.SourceDepartment of Agricultural Biotechnology and Center for Agricultural Biomaterials, Seoul National University, Seoul, 151-921, South Korea.
- Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2011 Aug;91(4):967-76. Epub 2011 May 3.
- Biosynthesis of guanosine 5'-diphosphate-L: -fucose (GDP-L: -fucose) requires NADPH as a reducing cofactor. In this study, endogenous NADPH regenerating enzymes such as glucose-6-phosphate dehydrogenase (G6PDH), isocitrate dehydrogenase (Icd), and NADP(+)-dependent malate dehydrogenase (MaeB) were o
- PMID 21538115
Japanese Journal
- P-73 グアノシン5'-二リン酸3'-二リン酸の葉緑体RNAポリメラーゼ結合部位に関する研究(ポスター発表の部)
- 佐藤 道大,高橋 公咲,保坂 毅,越智 幸三,鍋田 憲助
- 天然有機化合物討論会講演要旨集 (50), 481-486, 2008-09-01
- … Recently, bacterial alarmone guanosine 5'-diphosphate 3'-diphosphate (ppGpp), a key regulatory molecule controlling the stringent response, was identified in chloroplasts of plant cells. … We synthesized 6-thioguanosine 5'-diphosphate 3'-diphosphate (6-thioppGpp) as a photoaffinity probe of ppGpp, thus enabling the investigation of ppGpp binding to chloroplast RNA polymerase. …
- NAID 110007066722
- AMP-Activated Protein Kinase Activation by 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) Inhibits Palmitate-Induced Endothelial Cell Apoptosis Through Reactive Oxygen Species Suppression
- KIM Ji-Eun,KIM Yong-Woon,LEE In Kyu,KIM Jong-Yeon,KANG Young Jin,PARK So-Young
- Journal of pharmacological sciences 106(3), 394-403, 2008-03-20
- … The AMPK inhibitor compound C, dominant-negative AMPK, and the uncoupling protein inhibitor guanosine diphosphate block the antiapoptotic and antioxidative effects of AICAR. … The increase in uncoupling protein 2 (UCP2) by AICAR is also suppressed by compound C and guanosine diphosphate. … AICAR-mediated suppression of palmitate-induced p38 activation is also inhibited by guanosine diphosphate. …
- NAID 10024319031
Related Links
- Guanosine diphosphate, abbreviated GDP, is a nucleotide. It is an ester of pyrophosphoric acid with the nucleoside guanosine. GDP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase guanine. ...
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★リンクテーブル★
[★]
[★]
- 英
- guanosine diphosphate, GDP
- 関
- グアニン
[★]
グアノシン二リン酸糖
[★]
二リン酸エステル、二リン酸塩、二リン酸
- 関
- bisphosphate、diphosphoric acid、pyrophosphate