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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/08 22:35:15」(JST)
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Granulopoiesis (or granulocytopoiesis) is hematopoiesis of granulocytes.
It occurs primarily within bone marrow and involves the following stages:
- Pluripotential hemopoietic stem cell
- Myeloblast
- Promyelocyte
- Eosino/neutro/basophilic myelocyte
- Metamyelocyte
- Band cell (Stab cell)
- Granulocytes (Eosino/neutro/basophil)
It can be stimulated by Candida albicans.[1]
References
- ^ Basu S, Zhang HH, Quilici C, Dunn AR (February 2004). "Candida albicans can stimulate stromal cells resulting in enhanced granulopoiesis". Stem Cells Dev. 13 (1): 39–50. doi:10.1089/154732804773099245. PMID 15068692.
Myeloid physiology
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Hematopoiesis |
Myelopoiesis
(CFU-GEMM) |
CFU-GM |
- Granulopoiesis
- Myeloblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band cell
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MEP |
- Thrombopoiesis
- Megakaryoblast
- Promegakaryocyte
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- Erythropoiesis
- Proerythroblast
- Normoblast
- Reticulocyte
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General |
- Extramedullary hematopoiesis
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Hemostasis |
- Coagulation
- Clot retraction
- Platelet adhesiveness
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Other |
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Index of cells from bone marrow
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Description |
- Immune system
- Cells
- Physiology
- coagulation
- proteins
- granule contents
- colony-stimulating
- heme and porphyrin
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Disease |
- Red blood cell
- Monocyte and granulocyte
- Neoplasms and cancer
- Histiocytosis
- Symptoms and signs
- Blood tests
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Treatment |
- Transfusion
- Drugs
- thrombosis
- bleeding
- other
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UpToDate Contents
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English Journal
- GM-CSF treatment is not effective in congenital neutropenia patients due to its inability to activate NAMPT signaling.
- Koch C1, Samareh B2, Morishima T2, Mir P2, Kanz L2, Zeidler C1, Skokowa J2, Welte K3.
- Annals of hematology.Ann Hematol.2016 Dec 14. [Epub ahead of print]
- Severe congenital neutropenia (CN) is a bone marrow failure syndrome characterized by an absolute neutrophil count (ANC) below 500 cells/μL and recurrent, life-threatening bacterial infections. Treatment with granulocyte colony-stimulating factor (G-CSF) increases the ANC in the majority of CN pat
- PMID 27966038
- Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo.
- Wiesmeier M1, Gautam S1,2,3, Kirschnek S1, Häcker G1.
- PloS one.PLoS One.2016 Dec 12;11(12):e0168055. doi: 10.1371/journal.pone.0168055. eCollection 2016.
- Severe congenital neutropenia (SCN) is characterised by a differentiation block in the bone marrow and low neutrophil numbers in the peripheral blood, which correlates with increased risk of bacterial infections. Several underlying gene defects have been identified in SCN patients. Mutations in the
- PMID 27942017
- Moving the Boundaries of Granulopoiesis Modelling.
- Bernard S1.
- Bulletin of mathematical biology.Bull Math Biol.2016 Dec;78(12):2358-2363. Epub 2016 Oct 26.
- PMID 27785695
Japanese Journal
- <i>Clostridium perfringens</i> α-Toxin Impairs Lipid Raft Integrity in Neutrophils
- Non-steady-state hematopoiesis regulated by the C/EBPβ transcription factor.
Related Links
- Granulopoiesis This composite image shows the different stages of granulopoiesis for a neutrophil. Granulopoiesis begins when the myeloblast differentiates into a neutrophilic promyelocyte that is irreversibly committed to the ...
- Shashi K. Ramaiah, Mary B. Nabity, in Veterinary Toxicology, 2007 Granulopoiesis Granulopoiesis is the process by which committed hemopoietic progenitor cells develop into granulocytes under the influence of various growth ...
- the cessation of granulopoiesis during systemic illness, followed by the release of immature granulocytes into the circulation. Seen in cats. Called also toxic ... 9] It was also reported that the balance of erythropoiesis and granulopoiesis ...