glycosylceramidase

グリコシルセラミダーゼ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/02/24 06:43:33」(JST)

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glycosylceramidase
Identifiers
EC number	3.2.1.62
CAS number	9033-10-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a glycosylceramidase (EC 3.2.1.62) is an enzyme that catalyzes the chemical reaction

glycosyl-N-acylsphingosine + H₂O $\rightleftharpoons$ N-acylsphingosine + a sugar

Thus, the two substrates of this enzyme are glycosyl-N-acylsphingosine and H₂O, whereas its two products are N-acylsphingosine and sugar.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is glycosyl-N-acylsphingosine glycohydrolase. Other names in common use include phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin beta-glucosidase, lactase-phlorizin hydrolase, and phloridzin glucosidase.

References

• Leese HJ, Semenza G (1973). "On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase". J. Biol. Chem. 248 (23): 8170–3. PMID 4752949. 
• Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G (1972). "A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase". Eur. J. Clin. Invest. 2 (5): 326–31. doi:10.1111/j.1365-2362.1972.tb00658.x. PMID 5082068. 
• Malathi P, Crane RK (1969). "Phlorizin hydrolase: a beta-glucosidase of hamster intestinal brush border membrane". Biochim. Biophys. Acta. 173 (2): 245–56. doi:10.1016/0005-2736(69)90108-4. PMID 5774775. 

English Journal

• Flavonoid metabolism: the interaction of metabolites and gut microbiota.

• Murota K1, Nakamura Y2, Uehara M3.
• Bioscience, biotechnology, and biochemistry.Biosci Biotechnol Biochem.2018 Mar 5:1-11. doi: 10.1080/09168451.2018.1444467. [Epub ahead of print]
• PMID 29504827

• Molecular Ecological Basis of Grasshopper (Oedaleus asiaticus) Phenotypic Plasticity under Environmental Selection.

• Qin X1,2,3, Hao K1, Ma J1,3, Huang X1,3, Tu X1,3, Ali MP4, Pittendrigh BR5, Cao G1,3, Wang G1,3, Nong X1,3, Whitman DW6, Zhang Z1,3.
• Frontiers in physiology.Front Physiol.2017 Oct 10;8:770. doi: 10.3389/fphys.2017.00770. eCollection 2017.
• PMID 29066978

• Characterization of Mucosal Disaccharidases from Human Intestine.

• Amiri M1, Naim HY2.
• Nutrients.Nutrients.2017 Oct 10;9(10). pii: E1106. doi: 10.3390/nu9101106.
• PMID 28994704

Japanese Journal

• Analysis of behavior of sodiated sugar hemiacetals under low-energy collision-induced dissociation conditions and application to investigating mutarotation and mechanism of a glycosidase

• Kanie Osamu,Kurimoto Ayako,Kanie Yoshimi [他],DAIKOKU Shusaku,OHTAKE Atsuko,SUZUKI Katsuhiko
• Proceedings of the Japan Academy, Series B 85(6), 204-215, 2009
• … On the basis of these results, we could 1) observe the mutarotation of lactose and 2) speculate the hydrolysis mechanism of endo-glycosylceramidase by using mass spectrometry.(Communicated by Takao SEKIYA, M.J.A.) …
• NAID 130000138068

• Klotho-related protein is a novel cytosolic neutral β-glycosylceramidase

• HAYASHI Y
• J. Biol. Chem. 282, 30889-30900, 2007
• NAID 80018163328

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