English Journal

The 'sweet' spot of cellular pluripotency: protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine.

Wang YC1, Lin V, Loring JF, Peterson SE.
Expert opinion on biological therapy.Expert Opin Biol Ther.2015 May;15(5):679-87. doi: 10.1517/14712598.2015.1021329. Epub 2015 Mar 3.
INTRODUCTION: Human pluripotent stem cells (hPSCs) promise for the future of regenerative medicine. The structural and biochemical diversity associated with glycans makes them a unique type of macromolecule modification that is involved in the regulation of a vast array of biochemical events and cel
PMID 25736263

Synthesis of carbohydrate-scaffolded thymine glycoconjugates to organize multivalency.

Ciuk AK1, Lindhorst TK1.
Beilstein journal of organic chemistry.Beilstein J Org Chem.2015 May 7;11:668-74. doi: 10.3762/bjoc.11.75. eCollection 2015.
Multivalency effects are essential in carbohydrate recognition processes as occurring on the cell surface. Thus many synthetic multivalent glycoconjugates have been developed as important tools for glycobiological research. We are expanding this collection of molecules by the introduction of carbohy
PMID 26124869

New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.

Lehri-Boufala S1, Ouidja MO1, Barbier-Chassefière V1, Hénault E1, Raisman-Vozari R2, Garrigue-Antar L1, Papy-Garcia D1, Morin C1.
PloS one.PLoS One.2015 Jan 24;10(1):e0116641. doi: 10.1371/journal.pone.0116641. eCollection 2015.
The causes of Parkinson disease (PD) remain mysterious, although some evidence supports mitochondrial dysfunctions and α-synuclein accumulation in Lewy bodies as major events. The abnormal accumulation of α-synuclein has been associated with a deficiency in the ubiquitin-proteasome system and the
PMID 25617759

Japanese Journal

Human Genetic Disorders Caused by Mutations in Genes Encoding Biosynthetic Enzymes for Sulfated Glycosaminoglycans

Mizumoto Shuji,Ikegawa Shiro,Sugahara Kazuyuki
Journal of Biological Chemistry 288, 10953-10961, 2013-04-19
… This minireview focuses on growing glycobiological studies of recently described genetic diseases caused by disturbances in biosynthetic enzymes for sulfated GAGs. …
NAID 120005293271

武藤多津郎
臨床神経学 51(11), 849-852, 2011
… Many researchers now recognize the importance of glycobiological research achievements. … Furthermore, I will introduce you some evidences that many neurological disorders such as Alzheimer's disease and immune-mediated encephalitis have special relationships with glycobiological abnormalities. …
NAID 130004504887

Kato Keiko
Trends in glycoscience and glycotechnology 19(106), 99-112, 2007-03-02
神経の可塑的変化は、脳の高次機能の発現と維持に必須の反応であるが、ほとんどの可塑的変化は、いまだ現象論に留まっている。その中において、海馬を中心としたシナプス可塑性については、ずいぶんと分子レベルの解析が進んできており、特定の糖鎖構造が重要な役割を演じていることが明らかとなってきた。そこで本稿では、5種の糖鎖構造に焦点を絞り、シナプス可塑性への関わりについて解説する。
NAID 10019564525