グリシントランスアミナーゼ
WordNet
- a class of transferases that catalyze transamination (that transfer an amino group from an amino acid to another compound) (同)aminotransferase, aminopherase
- the simplest amino acid found in proteins and the principal amino acid in sugar cane
- genus of Asiatic erect or sprawling herbs: soya bean (同)genus Glycine
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/28 11:28:51」(JST)
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glycine transaminase |
Identifiers |
EC number |
2.6.1.4 |
CAS number |
9032-99-9 |
Databases |
IntEnz |
IntEnz view |
BRENDA |
BRENDA entry |
ExPASy |
NiceZyme view |
KEGG |
KEGG entry |
MetaCyc |
metabolic pathway |
PRIAM |
profile |
PDB structures |
RCSB PDB PDBe PDBsum |
Gene Ontology |
AmiGO / EGO |
Search |
PMC |
articles |
PubMed |
articles |
NCBI |
proteins |
|
In enzymology, a glycine transaminase (EC 2.6.1.4) is an enzyme that catalyzes the chemical reaction
- glycine + 2-oxoglutarate glyoxylate + L-glutamate
Thus, the two substrates of this enzyme are glycine and 2-oxoglutarate, whereas its two products are glyoxylate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is glycine:2-oxoglutarate aminotransferase. Other names in common use include glutamic-glyoxylic transaminase, glycine aminotransferase, glyoxylate-glutamic transaminase, L-glutamate:glyoxylate aminotransferase, and glyoxylate-glutamate aminotransferase. This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, pyridoxal phosphate.
References[edit]
- Nakada HI (1964). "Glutamic-glycine transaminase from rat liver". J. Biol. Chem. 239: 468–471. PMID 14169146.
- Thompson JS and Richardson KE (1966). "Isolation and chracterization of a glutamate-glycine transaminase from human liver". Arch. Biochem. Biophys. 117 (3): 599–603. doi:10.1016/0003-9861(66)90101-9.
UpToDate Contents
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English Journal
- A Glycine Oxidase Based High-Throughput Solid-Phase-Assay for Substrate Profiling and Directed Evolution of (R)- and (S)-Selective Amine Transaminases.
- Weiss MS, Pavlidis IV, Vickers C, Höhne M, Bornscheuer UT.
- Analytical chemistry.Anal Chem.2014 Oct 16. [Epub ahead of print]
- Transaminases represent one of the most important enzymes of the biocatalytic toolbox for chiral amine synthesis as they allow asymmetric synthesis with quantitative yields and high enantioselectivity. In order to enable substrate profiling of transaminases for acceptance of different amines, a glyc
- PMID 25321325
- The beneficial effect of soybean (Glycine max (L.) Merr.) leaf extracts in adults with prediabetes: a randomized placebo controlled trial.
- Choi MS1, Ryu R, Seo YR, Jeong TS, Shin DH, Park YB, Kim SR, Jung UJ.
- Food & function.Food Funct.2014 Jul 25;5(7):1621-30. doi: 10.1039/c4fo00199k.
- The present study investigated the effects of soybean leaf extracts (SLEs) on blood glucose, insulin resistance, body fat and dyslipidemia in prediabetes subjects, and compared them with the effects of banaba extracts (BE) which is known to ameliorate diabetes in several animals and clinical studies
- PMID 24873894
- Withholding parenteral nutrition during critical illness increases plasma bilirubin but lowers the incidence of biliary sludge.
- Vanwijngaerden YM1, Langouche L, Brunner R, Debaveye Y, Gielen M, Casaer M, Liddle C, Coulter S, Wouters PJ, Wilmer A, Van den Berghe G, Mesotten D.
- Hepatology (Baltimore, Md.).Hepatology.2014 Jul;60(1):202-10. doi: 10.1002/hep.26928. Epub 2014 Feb 26.
- Cholestatic liver dysfunction (CLD) and biliary sludge often occur during critical illness and are allegedly aggravated by parenteral nutrition (PN). Delaying initiation of PN beyond day 7 in the intensive care unit (ICU) (late PN) accelerated recovery as compared with early initiation of PN (early
- PMID 24213952
Japanese Journal
- Azurocidin induces elastinolytic activity of medullasin
- Aoki Yosuke
- Proceedings of the Japan Academy, Series B 82(7), 251-256, 2006
- … Addition of azurocidin, a protein in granulocytes similar to serine proteases but has no protease activity because of replacement of the active serine residue by glycine, to the incubation mixture containing medullasin induced elastinolytic activity of medullasin. … Medullasin activity determined by using apo-ornithine transaminase or casein as substrates or that by N-methoxy-succinyl-(Ala)2-Pro-Val-p-nitroanilide as substrate remained unchanged when azurocidin was added to the tube containing medullasin. …
- NAID 130000093845
- Beneficial Circulatory Effect of L-Arginine.
- Nakaki Toshio,Kato Ryuichi
- The Japanese Journal of Pharmacology 66(2), 167-171, 1994
- … This amino acid is a substrate for at least five enzymes identified in mammals, including arginase, arginine-glycine transaminase, kyotorphine synthase, nitric oxide synthase (NOS) and arginine decarboxylase. …
- NAID 130000840671
- 2. 微生物の高塩濃度環境における応答(セミナー「ストレスと生物のレスポンス」)
- 小野 比佐好
- 凍結及び乾燥研究会会誌 39, 68-72, 1993-10-20
- … Unlike glycine betaine it is not known about the regulatory systems of ectoine accumulation with response to hypersalinity. … But, all of the three enzymes, 2,4-diaminobutyric acid (2,4-DABA) transaminase, 2,4-DABA acetyltransferase, and ectoine synthase, were confirmed. …
- NAID 110007368532
Related Links
- Glycine Transaminase information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
- "Glycine Transaminase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).
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