WordNet

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Synthesis of a Suite of Bioorthogonal Glutathione S-Transferase Substrates and Their Enzymatic Incorporation for Protein Immobilization.

Voelker AE, Viswanathan R.SourceDepartment of Chemistry, Case Western Reserve University , Millis Science Center: Rm 216, 2074 Adelbert Road, Cleveland, Ohio 44106-7078, United States.
The Journal of organic chemistry.J Org Chem.2013 Oct 4;78(19):9647-9658. Epub 2013 Sep 23.
Label-free protein immobilization allows precise detection of biomolecular events. Preserving enzyme function is intrinsically challenging for these strategies. Considering that glutathione S-transferase (GST) is a broadly employed enzymatic fusion tag, we reported a label-free self-catalyzed immobi
PMID 23984983

Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients.

Babushok DV, Li Y, Roth JJ, Perdigones N, Cockroft JD, Biegel JA, Mason PJ, Bessler M.SourceDivision of Hematology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
American journal of hematology.Am J Hematol.2013 Oct;88(10):862-7. doi: 10.1002/ajh.23521. Epub 2013 Jul 23.
Acquired aplastic anemia (AA) is a rare life-threatening bone marrow failure syndrome, caused by autoimmune destruction of hematopoietic stem and progenitor cells. Epidemiologic studies suggest that environmental exposures and metabolic gene polymorphisms contribute to disease pathogenesis. Several
PMID 23798465

Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy.

Geenen S, du Preez FB, Snoep JL, Foster AJ, Sarda S, Kenna JG, Wilson ID, Westerhoff HV.SourceUniversity of Manchester, Manchester M1 7DN, UK.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Oct;1830(10):4943-59. doi: 10.1016/j.bbagen.2013.04.014. Epub 2013 Apr 30.
BACKGROUND: Glutathione metabolism can determine an individual's ability to detoxify drugs. To increase understanding of the dynamics of cellular glutathione homeostasis, we have developed an experiment-based mathematical model of the kinetics of the glutathione network. This model was used to simul
PMID 23643929

Metabolic Activation of Heterocyclic Amines and Expression of CYP1A1 in the Tongue

Takiguchi Mami,Darwish Wageh S.,Ikenaka Yoshinori,Ohno Marumi,Ishizuka Mayumi
Toxicological Sciences 116(1), 79-91, 2010-07
… In contrast, the expression levels of glutathione S-transferase (GST) and UDP-glucuronosyltransferase (UGT) in the tongue were considerably lower compared with those in the liver and, as a result, the mutagenic activity in the tongue was not decreased by GST- or UGT-dependent conjugation. …
NAID 120002834690

Hepatotoxicity and Immunotoxicity of 1-Bromohexane and Its Glutathione Conjugation in Female BALB/c Mice

Lee Sang Kyu,Lee Dong Ju,Ha Hyun Woo,Yoo Jin Woo,Ko Gyu Sub,Kang Mi Jeong,Kang Wonku,Jeong Hye Gwang,Lee Kyung Bok,Jeong Tae Cheon
JOURNAL OF HEALTH SCIENCE 56(4), 434-441, 2010
… Hepatotoxic and immunotoxic effects of 1-bromohexane (1-BH) and its conjugation with glutathione (GSH) were investigated in female BALB/c mice. …
NAID 130000303542