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Glutamyl aminopeptidase (EC 3.4.11.7, aminopeptidase A, aspartate aminopeptidase, angiotensinase A, glutamyl peptidase, Ca²⁺-activated glutamate aminopeptidase, membrane aminopeptidase II, antigen BP-1/6C3 of mouse B lymphocytes, L-aspartate aminopeptidase, angiotensinase A2) is an enzyme encoded by the ENPEP gene. Glutamyl aminopeptidase has also recently been designated CD249 (cluster of differentiation 249).

Glutamyl aminopeptidase is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. The enzyme degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.^[1]

References

^ Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C (2000). "Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure". Biochem. Soc. Trans. 28 (4): 435–40. doi:10.1042/0300-5127:0280435. PMID 10961935.

External links

The MEROPS online database for peptidases and their inhibitors: M01.003
Glutamyl aminopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

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UpToDate Contents

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1. 胆汁うっ滞系酵素の測定（アルカリホスファターゼ、5' -ヌクレオチダーゼ、γ-
グルタミルトランスペプチダーゼなど） enzymatic measures of cholestasis eg alkaline phosphatase 5 nucleotidase gamma glutamyl transpeptidase
2. ヘキソースリン酸側路およびグルタチオン代謝関連疾患 related disorders of the hexose monophosphate shunt and glutathione metabolism
3. ビタミンＫ、γカルボキシグルタミン酸、および凝固剤と他の蛋白質の機能 vitamin k gamma carboxyglutamic acid and the function of coagulation and other proteins
4. ビタミンＫおよびγカルボキシグルタミン酸の合成 vitamin k and the synthesis of gamma carboxyglutamic acid
5. 高血圧のマネージメントにおけるバゾペプチターゼ阻害剤 vasopeptidase inhibition in the management of hypertension

English Journal

Simple purification method for a recombinantly expressed native His-tag-free aminopeptidase A from Lactobacillus delbrueckii.

Stressler T1, Tanzer C2, Ewert J2, Claaßen W2, Fischer L2.
Protein expression and purification.Protein Expr Purif.2016 Nov 1;131:7-15. doi: 10.1016/j.pep.2016.10.010. [Epub ahead of print]
The aminopeptidase A (PepA; EC 3.4.11.7) is an intracellular exopeptidase present in lactic acid bacteria. The PepA cleaves glutamyl/aspartyl residues from the N-terminal end of peptides and can, therefore, be applied for the production of protein hydrolysates with an increased amount of these amino
PMID 27815133

[Clinical features of different clinical forms of childhood congenital hepatic fibrosis].

Wu X1, DU XR, Ding JF, Wu MJ, Luo SQ, Feng XZ.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.Zhongguo Dang Dai Er Ke Za Zhi.2016 Apr;18(4):335-9.
OBJECTIVE: To compare the clinical features of children with different clinical forms of congenital hepatic fibrosis (CHF), and provides a description of the characteristics of childhood CHF.METHODS: Sixty children with CHF between January 2002 and June 2015 were enrolled, including 26 children with
PMID 27097579

A Novel Glutamyl (Aspartyl)-Specific Aminopeptidase A from Lactobacillus delbrueckii with Promising Properties for Application.

Stressler T1, Ewert J1, Merz M1, Funk J2, Claaßen W1, Lutz-Wahl S1, Schmidt H2, Kuhn A3, Fischer L1.
PloS one.PLoS One.2016 Mar 22;11(3):e0152139. doi: 10.1371/journal.pone.0152139. eCollection 2016.
Lactic acid bacteria (LAB) are auxotrophic for a number of amino acids. Thus, LAB have one of the strongest proteolytic systems to acquit their amino acid requirements. One of the intracellular exopeptidases present in LAB is the glutamyl (aspartyl) specific aminopeptidase (PepA; EC 3.4.11.7). Most
PMID 27003449

Japanese Journal

胸肋鎖骨間異常骨化症を呈した原発性胆汁性肝硬変症

日大醫學雜誌 69(2), 86-89, 2010-04-01
NAID 10026314741

Purification and Characterization of an N-Terminal Acidic Amino Acid-Specific Aminopeptidase from Soybean Cotyledons (Glycine max)

Bioscience, biotechnology, and biochemistry 74(1), 113-118, 2010-01-23
NAID 10027550265

髄膜炎菌 Neisseria meningitidis の病原性に関する研究

日本細菌学雑誌 64(2), 291-301, 2009-12-25
NAID 10027208480

「グルタミルアミノペプチダーゼ」

glutamyl aminopeptidase (aminopeptidase A)
Identifiers
Symbol	ENPEP
Alt. symbols	gp160, CD249
Entrez	2028
HUGO	3355
OMIM	138297
RefSeq	NM_001977
UniProt	Q07075
Other data
EC number	3.4.11.7
Locus	Chr. 4 q25