WordNet
- a drug that neutralizes or counteracts the effects of another drug
- a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- a steroid hormone that is produced by the adrenal cortex of animals; affects functioning of gonads and has anti-inflammatory activity
PrepTutorEJDIC
- 対立する人,敵対者,競争相手(opponent)
- =sense organ / 受信装置
UpToDate Contents
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English Journal
- The multifaceted mineralocorticoid receptor.
- Gomez-Sanchez E1, Gomez-Sanchez CE.
- Comprehensive Physiology.Compr Physiol.2014 Jul 1;4(3):965-94. doi: 10.1002/cphy.c130044.
- The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol and corticosterone, act through the structurally similar mineralocorticoid (MR) and glucocorticoid receptors (GRs). Aldosterone is crucial for fluid, electrolyte, and hemodynamic homeostasis and tissue repai
- PMID 24944027
- Corticotropin-releasing hormone and the sympathoadrenal system are major mediators in the effects of peripherally administered exendin-4 on the hypothalamic-pituitary-adrenal axis of male rats.
- Gil-Lozano M1, Romaní-Pérez M, Outeiriño-Iglesias V, Vigo E, González-Matías LC, Brubaker PL, Mallo F.
- Endocrinology.Endocrinology.2014 Jul;155(7):2511-23. doi: 10.1210/en.2013-1718. Epub 2014 Apr 14.
- Glucagon-like peptide-1 (GLP-1) and the GLP-1 receptor agonist, exendin-4 (Ex-4), potently stimulate hypothalamic-pituitary-adrenal (HPA) axis activity after either central or peripheral administration. Because several GLP-1 derivative drugs, including synthetic Ex-4, are currently in use to treat p
- PMID 24731096
Japanese Journal
- Inhibitory Effects of Dexamethasone on Hepatocyte Growth Factor-Induced DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes
- Kimura Mitsutoshi,Moteki Hajime,Ogihara Masahiko
- Journal of pharmacological sciences 115(3), 390-398, 2011-03-20
- … M)-containing Williams' medium E with or without glucocorticoid receptor antagonists. … The inhibitory effects of dexamethasone were reversed by treatment with the glucocorticoid-receptor antagonist mifepristone (RU486, 10<SUP>-6</SUP> … M) or a monoclonal antibody against glucocorticoid receptor (100 ng/mL). …
- NAID 10029892847
- SM-368229, a Novel Selective and Potent Non-steroidal Mineralocorticoid Receptor Antagonist With Strong Urinary Na^+ Excretion Activity
- Nariai Tetsuro,Fujita Katsuya,Mori Masaya [他],KATAYAMA Seiji,HORI Seiji,MATSUI Kazuki
- Journal of pharmacological sciences 115(3), 346-353, 2011-03-20
- … Mineralocorticoid receptor (MR) antagonists, such as spironolactone (SPI) and eplerenone (EPL), are useful for the treatment of hypertension and heart failure. … In our search for safer and more effective MR antagonists, we identified SM-368229 as a novel non-steroidal MR antagonist. … The selectivity of SM-368229 for MR was 18-fold higher than that for other steroid receptors, such as androgen, progesterone, and glucocorticoid receptors. …
- NAID 10029892678
Related Links
- 1. Curr Top Med Chem. 2008;8(9):813-38. Glucocorticoid receptor antagonists. Clark RD. Corcept Therapeutics, 149 Commonwealth Avenue, Menlo Park, CA 94025, USA. rclark@corcept.com This review covers recent progress in the ...
- View and buy high purity Glucocorticoid Receptor antagonists from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... New Therapies and Challenges in Asthma Written by Peter J. Barnes ...
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