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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/30 10:57:56」(JST)

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Gliosarcoma is a rare type of glioma, a cancer of the brain that comes from glial, or supportive, brain cells, as opposed to the neural brain cells. Gliosarcoma is a malignant cancer, and is defined as a glioblastoma consisting of gliomatous and sarcomatous components.^[1]

It is estimated that approximately 2.1% of all glioblastomas are gliosarcomas. Although most gliomas rarely show metastases outside the cerebrum, gliosarcomas have a propensity to do so, most commonly spreading through the blood to the lungs, and also liver and lymph nodes.^[2]

Gliosarcomas have an epidemiology similar to that of glioblastomas, with the average age of onset being 54 years, and males being affected twice as often as females. They are most commonly present in the temporal lobe.

References

^ Ayadi L, Charfi S, Khabir A et al. (March 2010). "[Cerebral gliosarcoma: clinico-pathologic study of 8 cases]". Tunis Med (in French) 88 (3): 142–6. PMID 20415184.
^ Beumont; Kupsky, WJ; Barger, GR; Sloan, AE et al. (2007). "Gliosarcoma with multiple extracranial metastases: case report and review of the literature". J. Neurooncology 83 (1): 39–46. doi:10.1007/s11060-006-9295-x. PMID 17171442.

External links

Gliosarcoma entry in the public domain NCI Dictionary of Cancer Terms

This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

References

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1. 高グレードの神経膠腫患者の臨床症状および初回外科的アプローチ clinical manifestations and initial surgical approach to patients with high grade gliomas
2. 膠芽腫（グリオブラストーマ）および未分化星細胞腫に対する術後初回治療 initial postoperative therapy for glioblastoma and anaplastic astrocytoma
3. Management of glioblastoma in older adults
4. 神経膠腫の分類 classification of gliomas
5. 再発高グレード神経膠腫のマネージメント management of recurrent high grade gliomas

English Journal

FDG-PET/CT in a Patient with Poor-Risk Non-Seminoma Testis with Mature Teratoma and Secondary Gliosarcoma: Multimodality Imaging for Guiding Multimodality Treatment.

Quak E1, Kovacs I2, Oyen WJ3, van der Graaf WT4.
Nuclear medicine and molecular imaging.Nucl Med Mol Imaging.2015 Sep;49(3):237-40. doi: 10.1007/s13139-015-0321-9. Epub 2015 Feb 13.
The value of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting viable tumours in patients with metastasised non-seminomatous testicular cancer and residual and new masses post chemotherapy remains to be determined. We describe the case of a 41-year-ol
PMID 26279698

Phase I study of iniparib concurrent with monthly or continuous temozolomide dosing schedules in patients with newly diagnosed malignant gliomas.

Blakeley JO1, Grossman SA, Mikkelsen T, Rosenfeld MR, Peereboom D, Nabors LB, Chi AS, Emmons G, Ribas IG, Supko JG, Desideri S, Ye X.
Journal of neuro-oncology.J Neurooncol.2015 Aug 19. [Epub ahead of print]
Iniparib is a prodrug that converts to highly reactive cytotoxic metabolites intracellularly with activity in preclinical glioma models. We investigated the maximum tolerated dose (MTD) of iniparib with monthly (m) and continuous (c) temozolomide (TMZ) dosing schedules in patients with malignant gli
PMID 26285766

[Experimental study of dendritic cells transfected with cancer stem like cells RNA against 9L brain tumors].

Xiao ZY1, Chen XJ2, Yang Y3, Xu RX3.
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.Beijing Da Xue Xue Bao.2015 Aug 18;47(4):661-6.
OBJECTIVE: To investigate the anti-tumor efficacy of dendritic cells (DC) vaccination transfected with total RNA of cancer stem like cells and to discuss the mechanism of immune response, so as to provide experimental basis for clinical application.METHODS: Dendritic cells were isolated from F344 bo
PMID 26284406

Japanese Journal

Gliosarcoma arising from a fibrillary astrocytoma

Kobayashi Tatsuya,Sakai Keiichi,Tada Tsuyoshi,Sekiguchi Yasuyuki,Hara Yosuke,Kodama Kunihiko,Goto Tetsuya,Tanaka Yuichiro,Sano Kenji,Nakayama Jun,Hongo Kazuhiro
JOURNAL OF CLINICAL NEUROSCIENCE 18(9), 1251-1254, 2011-09-00
… We report a 67-year-old woman who was diagnosed with a gliosarcoma at a second operation after diagnosis of a fibrillary astrocytoma 5 months previously. … Tissue obtained from partial removal of the tumor revealed gliosarcoma (WHO grade IV), and LOH on 10q and 19q was detected. …
NAID 120005248197