WordNet

the ordering of genes in a haploid set of chromosomes of a particular organism; the full DNA sequence of an organism; "the human genome contains approximately three billion chemical base pairs"

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Use of comprehensive genomic profiling to direct point-of-care management of patients with gynecologic cancers.

Rodriguez-Rodriguez L1, Hirshfield KM2, Rojas V3, DiPaola RS2, Gibbon D2, Hellmann M4, Isani S2, Leiser A2, Riedlinger GM2, Wagreich A5, Ali SM6, Elvin JA6, Miller VA6, Ganesan S7.
Gynecologic oncology.Gynecol Oncol.2016 Apr;141(1):2-9. doi: 10.1016/j.ygyno.2016.02.021.
OBJECTIVE: To determine the feasibility and clinical utility of using comprehensive genomic profiling (CGP) in the course of clinical care to identify clinically relevant tumor genomic alterations for patients with either rare or refractory gynecologic cancers to facilitate point-of-care management.
PMID 27016222

Optimizing Surveillance for South American Origin Influenza A Viruses Along the United States Gulf Coast Through Genomic Characterization of Isolates from Blue-winged Teal (Anas discors).

Ramey AM1,2, Walther P3, Link P4, Poulson RL2, Wilcox BR2, Newsome G5, Spackman E6, Brown JD2, Stallknecht DE2.
Transboundary and emerging diseases.Transbound Emerg Dis.2016 Apr;63(2):194-202. doi: 10.1111/tbed.12244. Epub 2014 Jul 24.
Relative to research focused on inter-continental viral exchange between Eurasia and North America, less attention has been directed towards understanding the redistribution of influenza A viruses (IAVs) by wild birds between North America and South America. In this study, we genomically characteriz
PMID 25056712

Performance of optimized noncanonical amino acid mutagenesis systems in the absence of release factor 1.

Zheng Y1, Lajoie MJ2, Italia JS1, Chin MA1, Church GM3, Chatterjee A1.
Molecular bioSystems.Mol Biosyst.2016 Mar 30. [Epub ahead of print]
Site-specific incorporation of noncanonical amino acids (ncAAs) into proteins expressed in E. coli using UAG-suppression competes with termination mediated by release factor 1 (RF1). Recently, unconditional deletion of RF1 was achieved in a genomically recoded E. coli (C321), devoid of all endogenou
PMID 27027374

An alternative genome-integrated method for undomesticated <i>Bacillus subtilis</i> and related species

Mahipant Gumpanat,Kato Junichi,Kataoka Naoya,Vangnai Alisa S.
The Journal of General and Applied Microbiology 65(2), 96-105, 2019
… However, they are difficult to genomically modify due to their low transformation efficiencies. …
NAID 130007651711

Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice

Matsuzaki Hitomi,Okamura Eiichi,Kuramochi Daichi,Ushiki Aki,Hirakawa Katsuhiko,Fukamizu Akiyoshi,Tanimoto Keiji,松﨑仁美,谷本啓司,深水昭吉
Epigenetics & Chromatin (11), 36, 2018-06
… Although there are potential binding sites for ZFP57 (a candidate protein thought to control the methylation imprint) in the larger H19 ICR, they are not found in the 478-bp fragment, rendering the role of ZFP57 in postfertilization H19 ICR methylation a still open question.ConclusionsOur results demonstrate that a differentially methylated region can be reconstituted by combining the activities of specific imprinting elements and that these elements together determine the activity of a genomically imprinted region in vivo. …
NAID 120006501410

Genetic and physiological basis for antibody production by Kluyveromyces marxianus

Nambu-Nishida Yumiko,Nishida Keiji,Hasunuma Tomohisa,Kondo Akihiko
AMB Express (8), 56, 2018-04-12
… scFv production was obtained with strains carrying either plasmid-borne or genomically integrated constructs using various combinations of promoters (P-MDH1 or P-ACO1) and secretion signal peptides (KmINUss or Scα-MFss). …
NAID 120006462314