関: GALP

WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
amide combining the amino group of one amino acid with the carboxyl group of another; usually obtained by partial hydrolysis of protein
found pleasant or attractive; often used as a combining form; "a well-liked teacher"
Chinese distance measure; approximately 0.5 kilometers

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
(…の)『好み』,趣味《+『for』(『to』)+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/28 01:33:19」(JST)

wiki en

Galanin-like peptide (GALP) is a neuropeptide present in humans and other mammals. It is a 60-amino acid polypeptide produced in the arcuate nucleus of the hypothalamus and the posterior pituitary gland.^[1]^[2]^[3] It is involved in the regulation of appetite and may also have other roles such as in inflammation, sex behavior, and stress.^[4]^[5]^[6]^[7]^[8]^[9]

References

^ Seth A, Stanley S, Dhillo W, Murphy K, Ghatei M, Bloom S (February 2003). "Effects of galanin-like peptide on food intake and the hypothalamo-pituitary-thyroid axis". Neuroendocrinology 77 (2): 125–31. doi:10.1159/000068648. PMID 12624534.
^ Kageyama H, Takenoya F, Kita T, Hori T, Guan JL, Shioda S (March 2005). "Galanin-like peptide in the brain: effects on feeding, energy metabolism and reproduction". Regulatory Peptides 126 (1-2): 21–6. doi:10.1016/j.regpep.2004.08.029. PMID 15620409.
^ Kageyama H, Takenoya F, Hori Y, Yoshida T, Shioda S (January 2008). "Morphological interaction between galanin-like peptide- and dopamine-containing neurons in the rat arcuate nucleus". Regulatory Peptides 145 (1-3): 165–8. doi:10.1016/j.regpep.2007.08.019. PMID 17916390.
^ Man PS, Lawrence CB (July 2008). "Galanin-like peptide: a role in the homeostatic regulation of energy balance?". Neuropharmacology 55 (1): 1–7. doi:10.1016/j.neuropharm.2008.04.008. PMID 18538801.
^ Kuramochi M, Onaka T, Kohno D, Kato S, Yada T (April 2006). "Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat". Endocrinology 147 (4): 1744–52. doi:10.1210/en.2005-0907. PMID 16410310.
^ Taylor A, Madison FN, Fraley GS (March 2009). "Galanin-like peptide stimulates feeding and sexual behavior via dopaminergic fibers within the medial preoptic area of adult male rats". Journal of Chemical Neuroanatomy 37 (2): 105–11. doi:10.1016/j.jchemneu.2008.12.003. PMID 19124073.
^ Man PS, Lawrence CB (November 2008). "Interleukin-1 mediates the anorexic and febrile actions of galanin-like Peptide". Endocrinology 149 (11): 5791–802. doi:10.1210/en.2008-0252. PMC 3306896. PMID 18617619.
^ Lawrence CB (July 2009). "Galanin-like peptide modulates energy balance by affecting inflammatory mediators?". Physiology & Behavior 97 (5): 515–9. doi:10.1016/j.physbeh.2009.02.041. PMID 19298833.
^ Suzuki H, Onaka T, Dayanithi G, Ueta Y (June 2009). "Pathophysiological roles of galanin-like peptide in the hypothalamus and posterior pituitary gland". Pathophysiology 17 (2): 135–140. doi:10.1016/j.pathophys.2009.03.007. PMID 19501488.

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UpToDate Contents

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1. 2型糖尿病治療のためのGlucagon-like peptide-1受容体拮抗剤 glucagon like peptide 1 receptor agonists for the treatment of type 2 diabetes mellitus
2. 心不全におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in heart failure
3. 膵ポリペプチド、ペプチドYY、およびニューロペプチドY pancreatic polypeptide peptide yy and neuropeptide y
4. 成人における肥満：薬物療法 obesity in adults drug therapy
5. 関節リウマチの病因 pathogenesis of rheumatoid arthritis

English Journal

The antidepressant-like effect of alarin is related to TrkB-mTOR signaling and synaptic plasticity.

Zhuang F1, Li M2, Gao X2, Wang Y2, Wang D3, Ma X2, Ma T2, Gu S4.
Behavioural brain research.Behav Brain Res.2016 Jun 30. pii: S0166-4328(16)30421-1. doi: 10.1016/j.bbr.2016.06.057. [Epub ahead of print]
Alarin is a newly derived neuropeptide from a splice variant of the galanin-like peptide gene. We previously showed that alarin has an antidepressant-like effect by increasing the activity of the extracellular signal-regulated kinase (ERK) and protein kinase B (AKT) pathways, mediated by the tropomy
PMID 27374162

Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice.

Kageyama H1, Shiba K2, Hirako S3, Wada N2,4, Yamanaka S2, Nogi Y5, Takenoya F6, Nonaka N7, Hirano T5, Inoue S1, Shioda S8.
Scientific reports.Sci Rep.2016 Jun 21;6:28200. doi: 10.1038/srep28200.
Galanin-like peptide (GALP) has an anti-obesity effect in rats and mice. It has been reported that the uptake of GALP by the brain is higher after intranasal administration than with intravenous injection. This study therefore aimed to clarify the effect of intranasal administration of GALP on the f
PMID 27323911

Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation.

Wagner L1, Kaestner F2, Wolf R3, Stiller H4, Heiser U5, Manhart S5, Hoffmann T6, Rahfeld JU7, Demuth HU7, Rothermundt M8, von Hörsten S9.
Neuropeptides.Neuropeptides.2016 Jun;57:21-34. doi: 10.1016/j.npep.2016.02.007. Epub 2016 Feb 27.
BACKGROUND: Dipeptidyl peptidase 4 (DPP4; EC 3.4.14.5; CD26) is a membrane-bound or shedded serine protease that hydrolyzes dipeptides from the N-terminus of peptides with either proline or alanine at the penultimate position. Substrates of DPP4 include several stress-related neuropeptides implicate
PMID 26988064

Japanese Journal

GALPによる抗肥満の臨床応用に向けた点鼻投与法の開発

Drug Delivery System 28(4), 300-309, 2013
NAID 130003384380

ガラニン様ペプチド(GALP)の抗肥満効果について (メタボリックシンドローム2(後篇)メタボリックシンドロームの基礎) -- (成因と病態遺伝子・病態・標的分子の面から)

最新医学 66(-), 1487-1497, 2011-06
NAID 40018895492

1B-O-8 Effect of intranasal infusion of GALP on feeding and body weight regulation(The Proceedings of the 18th Annual Meetings of Japan Society Exercise and Sports Physiology Jury 31 August 1, (Kagoshima))