ガラクトシダーゼ
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/09 13:57:27」(JST)
[Wiki en表示]
Galactosidases are enzymes (glycoside hydrolases) that catalyze the hydrolysis of galactosides into monosaccharides.
If the galactoside is classified as an alpha-galactoside, the enzyme is called alpha-galactosidase, and if it is a beta-galactoside, it is called beta-galactosidase. Both varieties are categorized under the EC number 3.2.1.
Two recombinant forms of alpha-galactosidase are called agalsidase alfa (INN) and agalsidase beta (INN).
External links
- Galactosidases at the US National Library of Medicine Medical Subject Headings (MeSH)
Hydrolase: sugar hydrolases (EC 3.2)
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3.2.1: Glycoside hydrolases |
Disaccharidase |
- Sucrase/Sucrase-isomaltase/Invertase
- Maltase
- Trehalase
- Lactase
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Glucosidases |
- Cellulase
- Alpha-glucosidase
- Acid
- Neutral AB
- Neutral C
- Beta-glucosidase
- Debranching enzyme
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Other |
- Amylase
- Chitinase
- Lysozyme
- Neuraminidase
- NEU1
- NEU2
- NEU3
- NEU4
- Bacterial neuraminidase
- Viral neuraminidase
- Galactosidases
- alpha-Mannosidase
- Glucuronidase
- Hyaluronidase
- Pullulanase
- Glucosylceramidase
- Galactosylceramidase
- Alpha-N-acetylgalactosaminidase
- Alpha-N-acetylglucosaminidase
- Fucosidase
- Hexosaminidase
- Iduronidase
- Maltase-glucoamylase
- Heparanase
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3.2.2: Hydrolysing
N-Glycosyl compounds |
- DNA glycosylases: Oxoguanine glycosylase
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Metabolism, lipid metabolism, glycolipid enzymes
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Sphingolipid |
To glycosphingolipid |
- Glycosyltransferase
- Sulfotransferase
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To ceramide |
- From ganglioside
- Beta-galactosidase
- Hexosaminidase A
- Neuraminidase
- Glucocerebrosidase
- From globoside
- Hexosaminidase B
- Alpha-galactosidase
- Beta-galactosidase
- Glucocerebrosidase
- From sphingomyelin
- Sphingomyelin phosphodiesterase
- Sphingomyelin phosphodiesterase 1
- From sulfatide
- Arylsulfatase A
- Galactosylceramidase
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To sphingosine |
- Ceramidase
- ACER1
- ACER2
- ACER3
- ASAH1
- ASAH2
- ASAH2B
- ASAH2C
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Other |
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NCL |
- Palmitoyl protein thioesterase
- Tripeptidyl peptidase I
- CLN3
- CLN5
- CLN6
- CLN8
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Ceramide synthesis |
- Serine C-palmitoyltransferase (SPTLC1)
- Ceramide glucosyltransferase (UGCG)
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UpToDate Contents
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English Journal
- Inhibition of cyclodextrins on α-galactosidase.
- Yao D1, Zhu Z2, Cai H3, Chen X4, Sun W5, Barba FJ6, Li F7, Shen W8, Ding W9.
- Food chemistry.Food Chem.2017 Feb 15;217:59-64. doi: 10.1016/j.foodchem.2016.08.057. Epub 2016 Aug 21.
- This work successfully investigated the effects of different influential factors and hydrophobic cavities of cyclodextrins (CDs) on α-galactosidase (α-Gal) by detecting α-Gal activity. The highest inhibitory concentration of three kinds of CDs (α-, β-, and γ-CD) on α-Gal was 10mM. Moreover, t
- PMID 27664608
- Electrochemical biosensor for protein kinase A activity assay based on gold nanoparticles-carbon nanospheres, phos-tag-biotin and β-galactosidase.
- Zhou Y1, Yin H2, Li X3, Li Z3, Ai S3, Lin H4.
- Biosensors & bioelectronics.Biosens Bioelectron.2016 Dec 15;86:508-15. doi: 10.1016/j.bios.2016.07.004. Epub 2016 Jul 4.
- A sensitive and selective electrochemical biosensor was fabricated for protein kinase A (PKA) activity assay. Multiple signal amplification techniques were employed including the nanocomposite of gold nanoparticles and carbon nanospheres (Au@C), the biocomposite of SiO2 and streptavidin (SiO2-SA), t
- PMID 27442081
- Effect of xanthan/enzyme-modified guar gum mixtures on the stability of whey protein isolate stabilized fish oil-in-water emulsions.
- Chityala PK1, Khouryieh H2, Williams K1, Conte E1.
- Food chemistry.Food Chem.2016 Dec 1;212:332-40. doi: 10.1016/j.foodchem.2016.05.187. Epub 2016 Jun 1.
- The effect of xanthan gum (XG) and enzyme-modified guar (EMG) gum mixtures on the physicochemical properties and oxidative stability of 2wt% whey protein isolate (WPI) stabilized oil-in-water (O/W) emulsions containing 20%v/v fish oil was investigated. EMG was obtained by hydrolyzing native guar gum
- PMID 27374540
Japanese Journal
- Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction
- Kakiuchi Y.,Yurube T.,Kakutani K.,Takada T.,Ito M.,Takeoka Y.,Kanda Y.,Miyazaki S.,Kuroda R.,Nishida K.
- Osteoarthritis and Cartilage 27(6), 965-976, 2019-06
- … curcumin, 95% CI −0.248 to −0.011) and poly (ADP-ribose) polymerase (PARP) and caspase-9 cleavage, senescent senescence-associated beta-galactosidase (SA-β-gal) positivity (versus rapamycin, 95% CI −0.437 to −0.230; …
- NAID 120006645701
- Evaluation of synthetic gene encoding α-galactosidase through metagenomic sequencing of paddy soil
- Chen Yu-Pei,Liaw Li-Ling,Kuo Jong-Tar,Wu Hong-Tan,Wang Guey-Horng,Chen Xiu-Qin,Tsai Chai-Fang,Young Chiu-Chung
- Journal of Bioscience and Bioengineering, 2019-04-01
- NAID 210000155378
- ファブリー病の皮膚病変 (増大特集 神経学のための皮膚アトラス)
Related Links
- β-galactosidase, also called beta-gal or β-gal, is a hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and ...
- Two enzyme replacement therapies are available to functionally compensate for alpha-galactosidase deficiency. Agalsidase alpha and beta are both recombinant forms of the human α-galactosidase A enzyme and both have the same amino ...
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β-ガラクトシダーゼ・ノイラミニダーゼ欠乏症
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