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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/18 07:00:41」(JST)
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- 1. 赤血球表面抗原および細胞骨格蛋白質の異常によるマラリアに対する防御 protection against malaria by abnormalities in red cell surface antigens and cytoskeletal proteins
- 2. 肝細胞移植 hepatocyte transplantation
- 3. 交差適合試験での不適合 the incompatible crossmatch
- 4. ムコ多糖症：臨床的特徴および診断 mucopolysaccharidoses clinical features and diagnosis
English Journal
- Partial characterization and immunostimulatory activity of exopolysaccharides from Lactobacillus rhamnosus KF5.
- Shao L1, Wu Z2, Zhang H3, Chen W3, Ai L4, Guo B5.Author information 1School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Dairy Biotechnology, Technology Center of Bright Dairy & Food Co. Ltd., Shanghai 200436, China.2State Key Laboratory of Dairy Biotechnology, Technology Center of Bright Dairy & Food Co. Ltd., Shanghai 200436, China.3School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.4School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address: ailianzhong@hotmail.com.5School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; State Key Laboratory of Dairy Biotechnology, Technology Center of Bright Dairy & Food Co. Ltd., Shanghai 200436, China. Electronic address: awy7677@hotmail.com.AbstractLactobacillus rhamnosus KF5, a strain newly isolated from the faeces of a healthy human volunteer, has been shown to produce the exopolysaccharides (EPS) in skim milk. Two EPS fractions were separated from the fermented skim milk by removing proteins, ethanol precipitation, anion-exchange and gel permeation chromatography. Fraction S1, with a low average molecular weight of 1.36×10(4)Da, was composed of glucose, arabinose, glucosamine, galactosamine and galactose in an approximate molar ratio of 2.03:1.29:1.25:0.72:0.61. Such monosaccharide composition of the exopolysaccharide by lactic acid bacteria has not been reported so far, and S1 is likely to be an unusual type of microbial EPS. Whilst Fraction S2, with a high average molecular weight of 1.23×10(6)Da, contained rhamnose, glucose and galactose in a molar ratio of approximately 1.73:1.47:1.00. Both of EPS fractions could significantly stimulate splenocyte proliferation in vitro, indicating two EPS fractions had the potential immunomodulatory activity.
- Carbohydrate polymers.Carbohydr Polym.2014 Jul 17;107:51-6. doi: 10.1016/j.carbpol.2014.02.037. Epub 2014 Feb 20.
- Lactobacillus rhamnosus KF5, a strain newly isolated from the faeces of a healthy human volunteer, has been shown to produce the exopolysaccharides (EPS) in skim milk. Two EPS fractions were separated from the fermented skim milk by removing proteins, ethanol precipitation, anion-exchange and gel pe
- PMID 24702917
- Nature and mechanisms of hepatocyte apoptosis induced by D-galactosamine/lipopolysaccharide challenge in mice.
- Wu YH1, Hu SQ1, Liu J1, Cao HC2, Xu W2, Li YJ2, Li LJ2.Author information 1Zhejiang Provincial Key Laboratory of Biometrology and Inspection and Quarantine, Department of Pharmacy, College of Life Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, P.R. China.2State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.AbstractApoptosis plays a role in the normal development of liver. However, overactivation thereof may lead to hepatocellular damage. The aim of this study was to assess D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced hepatocyte apoptotic changes in mice and clarify the mechanisms involved in this process. DNA ladder detection was employed to determine the induction condition of hepatic apoptosis. An initial test indicated that typical hepatocyte apoptosis was observed at 6-10 h after the intraperitoneal injection of D-GalN (700 mg/kg) and LPS (10 µg/kg). Subsequently, we evaluated hepatocyte apoptosis at 8 h after administering D-GalN/LPS by histopathological analysis, terminal deoxynucleotidyl transferase-mediated dUTP nick end‑labeling (TUNEL) detection, flow cytometry and electron microscopy analysis. To clarify the apoptosis-related gene expression, the expression levels of tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), caspase-3, and Fas/Fas ligand (FasL) were determined by serum enzyme immunoassay, immunohistochemistry and western blot analysis. Strong apoptotic positive signals following D-GalN/LPS injection were observed from the results of the serum analysis, histopathological and immunohistochemical analyses, DNA ladder detection, TUNEL detection, flow cytometry and electron microscopy analysis. Additionally, apoptotic hepatocytes were mainly at the late stage of cell apoptosis. The expression of TNF-α, TGF-β1, caspase-3 and Fas/FasL was significantly increased. In conclusion, this study evaluated the D-GalN/LPS-induced hepatocyte apoptotic changes and clarified the apoptosis-related gene expression in mice. The hepatocyte apoptosis induced by D-GalN/LPS may be mainly regulated by the death receptor pathway. TGF-β signaling pathway may also play a vital role in this process of hepatocyte apoptosis.
- International journal of molecular medicine.Int J Mol Med.2014 Jun;33(6):1498-506. doi: 10.3892/ijmm.2014.1730. Epub 2014 Apr 7.
- Apoptosis plays a role in the normal development of liver. However, overactivation thereof may lead to hepatocellular damage. The aim of this study was to assess D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced hepatocyte apoptotic changes in mice and clarify the mechanisms involved in this
- PMID 24714963
- Glycine propionyl l-carnitine attenuates d-Galactosamine induced fulminant hepatic failure in wistar rats.
- Ganai AA1, Jahan S2, Ahad A3, Abdin MZ4, Farooqi H5.Author information 1Department of Biotechnology, Jamia Hamdard, New Delhi 110062, India. Electronic address: ganaikashmir@gmail.com.2Developmental Toxicology Division, Indian Institute of Toxicology Research, Lucknow 226001, Uttar Pradesh, India. Electronic address: jahan149@gmail.com.3Department of Biochemistry, Jamia Hamdard, New Delhi 110062, India. Electronic address: amjidpar12@gmail.com.4Department of Biotechnology, Jamia Hamdard, New Delhi 110062, India. Electronic address: mzabdin@rediffmail.com.5Department of Biotechnology, Jamia Hamdard, New Delhi 110062, India. Electronic address: humbiotech@gmail.com.AbstractGlycine propionyl l-carnitine (GPLC) is a propionyl ester of carnitine that includes an additional glycine component. The present study evaluated hepatoprotective effect of GPLC in d-Galactosamine (d-GalN) induced fulminant hepatic failure. Rats were intraperitonially administered d-GalN (700mg/kgBW). GPLC was given as a pre-treatment (35mg/kgBW/day) for 1month followed by a single dose of d-GalN on the 31st day. d-GalN administration resulted in increased mortality and serum ALT and AST activities. These increases were significantly attenuated by GPLC. d-GalN treatment increased hepatic lipid peroxidation and a decrease in reduced glutathione content was observed. GPLC pre-treatment significantly decreased lipid peroxidation and augmented the level of GSH. d-GalN increased the circulating level of TNF-α and ATM-Kinase and MAP-Kinase expression. GPLC supplementation inhibited the increase in serum TNF-α and ATM-Kinase and MAP-Kinase expression. d-GalN treatment increased the level of Bax and Caspase-3 m-RNA while as a decline was observed in Bcl2 m-RNA. GPLC prevented the increase in Caspase-3 and Bax m-RNA and at the same time augmented the expression of Bcl2 m-RNA. Our findings suggest that GPLC alleviates d-GalN induced liver injury by strengthening antioxidative defense system and reducing apoptotic signalling pathways.
- Chemico-biological interactions.Chem Biol Interact.2014 May 5;214:33-40. doi: 10.1016/j.cbi.2014.02.006. Epub 2014 Feb 22.
- Glycine propionyl l-carnitine (GPLC) is a propionyl ester of carnitine that includes an additional glycine component. The present study evaluated hepatoprotective effect of GPLC in d-Galactosamine (d-GalN) induced fulminant hepatic failure. Rats were intraperitonially administered d-GalN (700mg/kgBW
- PMID 24565947
Japanese Journal
- Novel hemagglutinating, hemolytic and cytotoxic activities of the intermediate subunit of Entamoeba histolytica lectin
- Scientific Reports 5, 13901, 2015-09-10
- NAID 120005656398
- Possible involvement of Tachylectin-2-like lectin from Acropora tenuis in the process of Symbiodinium acquisition
- Fisheries science 81(3), 473-483, 2015-05
- NAID 40020473060
- Lectin-binding sites in epithelial cells of the mouse prostate gland
- Okajimas Folia Anatomica Japonica 91(4), 91-95, 2015
- NAID 130005070820
Related Links
- ガラクトサミン(Galactosamine)は、ガラクトースから誘導されたヘキソサミンである。 このアミノ糖は、卵胞刺激ホルモン(FSH)や黄体形成ホルモン(LH)のようないくつかの 糖タンパク質のホルモンを構成している。FSHとLHにはガラクトサミンの他に グルコサミン、 ...
- Sigma-Aldrich offers Sigma-D-(+)-Galactosamine hydrochloride for your research needs. Find product specific information, including CAS, MSDS, protocols and references.
Related Pictures
★リンクテーブル★
| リンク元 | 「ガラクトサミン」 |
| 拡張検索 | 「N-acetyl-D-galactosamine」「acetylgalactosamine」「N-acetylgalactosamine」 |
「ガラクトサミン」
- 英
- galactosamine
- 同
- コンドロサミン chondrosamine, 2-amino-2-deoxygalactose
- 関
- アミノ糖
「N-acetyl-D-galactosamine」
「acetylgalactosamine」
「N-acetylgalactosamine」
- 同
- GalNAc