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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/04/13 21:59:54」(JST)

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Gadoteridol (INN) is a gadolinium-based MRI contrast agent, used particularly in the imaging of the central nervous system. It is sold under the brand name ProHance.

References

Bracco Diagnostic Inc. (May 2007). "Gadoteridol (ProHance) prescribing information (revised May 2007)". DailyMed. U.S. National Library of Medicine. Retrieved 2008-07-13.

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English Journal

Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.

Jahangiri A1, Chin AT1, Flanigan PM1, Chen R1, Bankiewicz K1, Aghi MK1.
Journal of neurosurgery.J Neurosurg.2017 Jan;126(1):191-200. doi: 10.3171/2016.1.JNS151591. Epub 2016 Apr 1.
Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their ther
PMID 27035164

Evaluation of a tailored injection profile (TIP) algorithm for uniform contrast-enhanced signal intensity profiles in MR angiography.

Wilson GJ1, Maki JH1.
Journal of magnetic resonance imaging : JMRI.J Magn Reson Imaging.2016 Dec;44(6):1664-1672. doi: 10.1002/jmri.25298. Epub 2016 May 5.
PURPOSE: To evaluate a contrast agent injection method that provides constant magnetic resonance imaging (MRI) signal intensity throughout a contrast-enhanced MR angiography acquisition.MATERIALS AND METHODS: A tailored injection profile (TIP) algorithm was developed that used the signal intensity p
PMID 27149390

Gadolinium deposition disease: Initial description of a disease that has been around for a while.

Semelka RC1, Ramalho J2, Vakharia A3, AlObaidy M4, Burke LM3, Jay M5, Ramalho M6.
Magnetic resonance imaging.Magn Reson Imaging.2016 Dec;34(10):1383-1390. doi: 10.1016/j.mri.2016.07.016. Epub 2016 Aug 13.
PURPOSE: To describe the clinical manifestations of presumed gadolinium toxicity in patients with normal renal function.MATERIALS AND METHODS: Participants were recruited from two online gadolinium toxicity support groups. The survey was anonymous and individuals were instructed to respond to the su
PMID 27530966

Japanese Journal

Comparison between Two Separate Injections and a Single Injection of Double-dose Contrast Medium for Contrast-enhanced MR Imaging of Metastatic Brain Tumors

OCHI Tomoko,TAOKA Toshiaki,MATSUDA Ryosuke,SAKAMOTO Masahiko,AKASHI Toshiaki,TAMAMOTO Tetsuro,SUGIMOTO Tadashi,SAKAGUCHI Hiroshi,HASEGAWA Masatoshi,NAKASE Hiroyuki,KICHIKAWA Kimihiko
Magnetic Resonance in Medical Sciences 13(4), 221-229, 2014
… Group A received 2 separate injections (0.2 + 0.2 mL/kg) of contrast medium (gadoteridol); …
NAID 130004935505

Comparison between Two Separate Injections and a Single Injection of Double-dose Contrast Medium for Contrast-enhanced MR Imaging of Metastatic Brain Tumors

OCHI Tomoko,TAOKA Toshiaki,MATSUDA Ryosuke,SAKAMOTO Masahiko,AKASHI Toshiaki,TAMAMOTO Tetsuro,SUGIMOTO Tadashi,SAKAGUCHI Hiroshi,HASEGAWA Masatoshi,NAKASE Hiroyuki,KICHIKAWA Kimihiko
Magnetic Resonance in Medical Sciences, 2014
… Group A received 2 separate injections (0.2 + 0.2 mL/kg) of contrast medium (gadoteridol); …
NAID 130004685116

Time Course for Measuring Endolymphatic Size in Healthy Volunteers Following Intravenous Administration of Gadoteridol

NAGANAWA Shinji,SUZUKI Kojiro,YAMAZAKI Masahiro,SAKURAI Yasuo,IKEDA Mitsuru
Magnetic Resonance in Medical Sciences 13(2), 73-80, 2014
Purpose: We developed semi-quantitative methods to measure endolymphatic size on images obtained 4 hours after intravenous administration of single-dose gadolinium-based contrast medium (IV-SD-GBCM) a …
NAID 130003393001

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「ガドテリドール」

Gadoteridol
Clinical data
Synonyms	(10-(2-(hydroxy-κO)propyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3−)-κN1,κN4,κN7,κN10,κO1,κO4,κO7)-gadolinium
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	IV
ATC code	V08CA04 (WHO);
Legal status
Legal status	US: ℞-only;
Identifiers
	IUPAC name gadolinium(+3) cation; 2-[4-(2-hydroxypropyl)-7,10-bis(2-oxido-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetate;
CAS Number	120066-54-8 ;
PubChem CID	60714;
DrugBank	DB00597 ;
ChemSpider	54719 ;
UNII	0199MV609F;
KEGG	D01137 ;
ChEBI	CHEBI:31643 ;
ChEMBL	CHEMBL1200593 ;
Chemical and physical data
Formula	C17H29GdN4O7
Molar mass	558.68 g/mol
3D model (JSmol)	Interactive image;
	SMILES [Gd+3].[O-]C(=O)CN1CCN(CCN(CCN(CC(O)C)CC1)CC([O-])=O)CC([O-])=O ;
	InChI InChI=1S/C17H32N4O7.Gd/c1-14(22)10-18-2-4-19(11-15(23)24)6-8-21(13-17(27)28)9-7-20(5-3-18)12-16(25)26;/h14,22H,2-13H2,1H3,(H,23,24)(H,25,26)(H,27,28);/q;+3/p-3 ; Key:DPNNNPAKRZOSMO-UHFFFAOYSA-K ;
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英: gadoteridol
商: プロハンス
関: ガドリニウム。その他の診断用薬

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gadoteridol